Publications

· Esther Klingler, Fiona Francis, Denis Jabaudon* & Silvia Cappello*. Mapping the molecular and cellular complexity of cortical malformations. Science, 2021.

· Juan Paraíso-Luna, José Aguareles, Ricardo Martín, Ane C. Ayo-Martín, Samuel Simón-Sánchez, Daniel García-Rincón, Carlos Costas-Insua, Elena García-Taboada, Adán de Salas-Quiroga, Javier Díaz-Alonso, Isabel Liste, José Sánchez-Prieto, Silvia Cappello, Manuel Guzmán, Ismael Galve-Roperh. Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB₁ receptors. Development, 2020.

· Ane Cristina Ayo-Martin, Christina Kyrousi, Rossella Di Giaimo and Silvia Cappello. GNG5 controls the number of apical and basal progenitors and alters neuronal migration during cortical development. Frontiers Molecular Biosciences, 2020.

· Fiona Francis and Silvia Cappello. Neuronal migration and disorders – an update. Current Opinion in Neurobiology, 2020.

· Jonas Drechsel, Christina Kyrousi, Silvia Cappello and Stephan A. Sieber. Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chemical Biology, 2020.

· Pavel Kielkowski, Silvia Cappello and Stephan A. Sieber. From young to old: AMPylation hits the brain. Cell Chemical Biology, 2020, 27(7):773-779.

· Michele Bertacchi, Anna Lisa Romano, Agnès Loubat, Frederic Tran Mau-Them, Marjolaine Willems, Laurence Faivre, Philippe Khau van Kien, Laurence Perrin, Françoise Devillard, Arthur Sorlin, Paul Kuentz, Christophe Philippe, Aurore Garde, Rossella Di Giaimo, Silvia Cappello, Ludovico D’Incerti, Carolina Frassoni and Michèle Studer. Altered regional progenitor cell dynamics in a mouse model of BBSOA syndrome shed light on cortical folding malformations. EMBO Journal, 2020, 39(13):e104163.

· Francesco Di Matteo*, Fabrizia Pipicelli*, Christina Kyrousi, Martina Giordano, Elisabeth Binder, Laura Canafoglia, Magdalena Gotz, Rossella Di Giaimo^# and Silvia Cappello^#. Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy. EMBO Molecular Medicine, 2020, 12(6):e11419.

· Isabel Y. Buchsbaum, Pavel Kielkowski, Grazia Giorgio, Adam C. O’Neill, Rossella di Giaimo, Christina Kyrousi, Shahryar Khattak, Stephan A. Sieber, Stephen P. Robertson and Silvia Cappello. ECE2 regulates Neurogenesis and Neuronal Migration during Human Cortical Development. EMBO Reports, 2020.

· Pavel Kielkowski*, Isabel Y. Buchsbaum*, Tobias Becker, Kathrin Bach, Silvia Cappello and Stephan A. Sieber. A pronucleotide probe for live cell imaging of protein AMPylation. ChemBioChem, 2020, 21,1-4.

· Pavel Kielkowski* Isabel Y. Buchsbaum*, Volker C. Kirsch, Nina C. Bach, Micha Drukker, Silvia Cappello^# and Stephan A. Sieber^#. FICD activity and AMPylation remodelling modulate human neurogenesis. Nature Communications 2020, 11:517.

· Jan A. Kullmann*, Sophie Meyer*, Fabrizia Pipicelli*, Christina Kyrousi, Felix Schneider, Nora Bartels, Silvia Cappello and Marco B. Rust. Profilin1-dependent F-actin assembly controls division of apical radial glia and neocortex development. Cerebral Cortex, 2019.

· Eduardo Penna, Angela Cerciello, Angela Chambery, Rosita Russo, Filippo Maria Cernilogar, Emilia Maria Pedone, Carla Perrone-Capano, Silvia Cappello, Rossella Di Giaimo and Marianna Crispino. Cystatin B involvement in synapse physiology of rodents’ brain and human cerebral organoids. Frontiers in Molecular Neuroscience 2019, 12:195

· Christina Kyrousi & Silvia Cappello. Using brain organoids to study neurodevelopment. WIREs Developmental Biology 2019, May 9:e347.

· Johannes Klaus*, Sabina Kanton*, Christina Kyrousi*, Adam C. O’Neill, Gray Camp, Ane C. Ayo-Martin, Rossella Di Giaimo, Stephan Riesenberg, Chiara Tocco, Malgorzata Gac, Ejona Rusha, Micha Drukker, Mariana Schroeder, Magdalena Götz, Stephen P. Robertson, Barbara Treutlein^# and Silvia Cappello^#. Altered neuronal migratory trajectories in human cerebral organoids derived from individuals with neuronal heterotopia. Nature Medicine, 2019

· Isabel Y. Buchsbaum & Silvia Cappello. Neuronal migration in the CNS during development and disease: insights from in vivo and in vitro models. Development 2019, 146:dev163766.

· Adam C. O’Neill, Christina Kyrousi, Johannes Klaus, Richard J. Leventer, Edwin P. Kirk, Andrew Fry, Daniela T. Pilz, Tim Morgan, Zandra A. Jenkins, Micha Drukker, Samuel F. Berkovic, Ingrid E. Scheffer, Renzo Guerrini, David M. Markie, Magdalena Götz, Silvia Cappello*^# and Stephen P. Robertson*^#. A primate-specific isoform of PLEKHG6 regulates neurogenesis and neuronal migration. Cell Reports 2018, 25, 2729–2741. - *equally contributing authors, ^#corresponding authors

· Francesc Pérez-Brangulí*^#, Isabel Y. Buchsbaum*, Tatyana Pozner*, Martin Regensburger, Wenqiang Fan, Annika Schray, Tom Börstler, Himanshu Mishra, Daniela Gräf, Zacharias Kohl, Jürgen Winkler, Benedikt Berninger, Silvia Cappello^# and Beate Winner^#. Human SPG11 cerebral organoids reveal cortical neurogenesis impairment. Human Molecular Genetics 2018, ddy397. - *equally contributing authors, ^#corresponding authors

· Silvia Cappello. Gyrification needs correct sodium flux. Neuron 2018, 99(5):867-868.

· Adrián Cárdenas, Camino de Juan Romero, Esther Picó, Ana Villalba, Christina Kyrousi, Athanasia C. Tzika, Marc Tessier-Lavigne, Le Ma, Micha Drukker, Silvia Cappello and Víctor Borrell. Control of progenitor cell lineage defining cerebral cortex size in amniotes. Cell 2018, 174(3)-590-606.

· Adam C. O’Neill, Christina Kyrousi, Melanie Einsiedler, Ingo Burtscher, Micha Drukker, David M. Markie, Edwin P. Kirk, Magdalena Götz, Stephen P. Robertson and Silvia Cappello. Mob2 insufficiency disrupts neuronal migration in the developing cortex. Frontiers in Cellular Neuroscience 2018, 12:57

· Filippo Cernilogar, Rossella Di Giaimo, Frederick Rehfeld, Silvia Cappello and D. Chichung Lie. RNA interference machinery-mediated gene regulation in mouse adult neural stem cells. BMC Neuroscience 2015, 19;16(1):60

· Marie-Theres Schmid, Franziska Weinandy, Silvia Cappello^# and Magdalena Götz^#. The role of α-E-catenin in cerebral cortex development: radial glia specific effect on neuronal migration. Frontiers in Neuroscience 2014, 8:215 - ^#corresponding authors

^· Silvia Cappello, Mary J. Gray, Caroline Badouel, Simona Lange, Melanie Einsiedler, Myriam Srour, David Chitayat, Fadi F. Hamdan, Zandra A. Jenkins, Tim Morgan, Nadia Preitner, Tami Uster, Jackie Thomas, Patrick Shannon, Victoria Morrison, Nataliya Di Donato, Lionel Van Maldergem, Teresa Neuhann, Ruth Newbury-Ecob, Marielle Swinkells, Paulien Terhal, Louise C. Wilson, Petra J.G. Zwijnenburg, Andrew J. Sutherland-Smith, Michael A. Black, David Markie, Jacques L. Michaud, Michael A. Simpson, Sahar Mansour, Helen McNeill, Magdalena Götz and Stephen P. Robertson. Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development. Nature Genetics 2013, 45(11):1300-1308 - highlighted by Faculty of 1000

· Ronny Stahl, Tessa Walcher, Camino De Juan Romero, Gregor Alexander Pilz, Silvia Cappello, Martin Irmler, José Miguel Sanz Anquela, Johannes Beckers, Robert Blum, Victor Borrell and Magdalena Götz. Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate. Cell 2013, 153(3):535-549

· Silvia Cappello. Small Rho-GTPases and cortical malformations: fine-tuning the cytoskeleton stability. Small GTPases 2013, 4(1):51-56

· Silvia Cappello*, Christian R.J. Böhringer*, Matteo Bergami, Karl-Klaus Conzelmann, Alexander Ghanem, Giulio Srubek Tomassy, Paola Arlotta, Marco Mainardi, Matteo Caleo, Jolanda van Hengel, Cord Brakebusch and Magdalena Götz. A radial glia specific role of RhoA in double-cortex formation. Neuron 2012, 73(5):911-924 - *equally contributing authors

· Silvia Cappello*^#, Pascale Monzo* and Richard B. Vallee^#. NudC is required for interkinetic nuclear migration and neuronal migration during cortical development. Developmental Biology 2011, 357(2):326-35 - *equally contributing authors, ^#corresponding authors

· Pia A. Johansson, Silvia Cappello and Magdalena Götz. Stem cells niches during development - lessons from the cerebral cortex. Current Opinion in Neurobiology 2010, 10(4):400-407

· Rajarshi Sengupta, Silvia Burbassi, Saori Shimizu, Silvia Cappello, Richard B. Vallee, Joshua B. Rubin and Olimpia Meucci. Morphine Increases Brain Levels of Ferritin Heavy Chain Leading to Inhibition of CXCR4-Mediated Survival Signaling in Neurons. The Journal of Neuroscience 2009, 29(8):2534-2544

· Silvia Cappello, Alessio Attardo, Xunwei Wu, Takuji Iwasato, Shigeyoshi Itohara, Michaela Wilsch-Bräuninger, Hanna M. Eilken, Michael A. Rieger, Timm T. Schroeder, Wieland B. Huttner, Cord Brakebusch and Magdalena Götz. The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nature Neuroscience 2006, 9(9):1099-1117 - highlighted by Faculty of 1000

· Spartaco Santi*, Silvia Cappello*, Massimo Riccio, Matteo Bergami, Giorgio Aicardi, Ursula Schenk, Michela Matteoli and Marco Canossa. Hippocampal neurons recycle BDNF for activity-dependent secretion and LTP maintenance. EMBO Journal 2006, 25(18):4372–4380 - *equally contributing authors

· Giorgio Aicardi*, Emanuela Argilli*, Silvia Cappello*, Spartaco Santi, Massimo Riccio, Hans Thoenen and Marco Canossa. Induction of long-term potentiation and depression is reflected by corresponding changes in secretion of endogenous brain-derived neurotrophic factor. PNAS 2004, 101(44):15788-15792 - *equally contributing authors

· Roberto DeGiorgio, Monica Bovara, Giovanni Barbara, Marco Canossa, Giovanni Sarnelli, Fabrizio DePonti, Vincenzo Stangellini, Marcello Tonini, Silvia Cappello, Eleonora Pagnotta, Eduardo Nobile-Orazio and Roberto Corinaldesi. Anti-Hu-induced neuronal Apoptosis underlying paraneoplastic gut dysmotility. Gastroenterology 2003, 125(1):70-79

· Marco Canossa, Emanuele Giordano, Silvia Cappello, Carlo Guarnieri and Sergio Ferri. Nitric Oxide downregulate brain derived neurotrophic factor secretion in cultured hippocampal neurons. PNAS 2002, 99(5):3282-3287