Changhwan Ahn, D.V.M., Ph.D.

EDUCATION

March 2014 – February 2019

Ph.D., Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea

March 2012 – February 2014

M.S., Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea

March 2006 – February 2012

B.S., College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea

RESEARCH EXPERIENCE

 March 2025 -

Associate Professor, Laboratory of Veterinary Physiology, College of Veterinary Medicine, Jeju National University, Republic of Korea

Mar 2021 – March 2025

Assistant Professor, Laboratory of Veterinary Physiology, College of Veterinary Medicine, Jeju National University, Republic of Korea

April 2019 – Feb 2021

Postdoctoral associate, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, USA

February 2019 – April 2019

Postdoctoral associate, Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea

CAREER

March 2023 – Present

Journal of Biomedical and Translational Research  Editorial Board Member

March 2023 – Present

Korean Society of Ginseng Board Member

January 2023 – December 2024

Korean Society for Alternative to Animal Experiments  Editorial Board Member

January 2024 - Present

Journal of Veterinary Science Editorial Board Member

January 2024 - Present

Head of the Jeju Branch, Korean Society of Toxicology

March 2024 – February 2025

Head of the Pre-Veterinary Medicine Department, College of Veterinary Medicine, Jeju National University, Jeju, Republic of Korea

March 2025 – Present

Director of the Research Institute of Veterinary Science, College of Veterinary Medicine, Jeju National University, Jeju, Republic of Korea

[연구의 흐름]

석사과정 및 박사과정: 충북대학교 수의과대학에서 Calcium을 기반으로 한 질병모델 개발 및 각 질병에서의 칼슘 관련 단백질의 역할 규명

Postdoc: Cornell University에서 Host-microbe interaction 연구. Salmonella typhi, 즉 장티푸스균은 인간을 host로 하기 때문에, 설치류로 진행한 연구에서는 오랜 기간 진행해야 하는 잠복감염(persistent infection)을 연구하기 어려웠기에, 이를 organoid (장, 쓸개)를 구축하여 장티푸스균의 잠복감염 연구를 수행하였음.

PI: 제주대학교에서 오가노이드를 이용한 질병모델 제작, 오가노이드를 이용한 재생의학 연구를 수행 중. 

• 장 오가노이드를 이용한 질병모델 제작 - 기전 연구

• 오가노이드를 이용한 천연물질의 안전성/유효성 평가 연구

• 신장 오가노이드를 이용한 재생 의학 연구

• 제주대학교 수의과대학 동물병원, 충북대학교 수의과대학 동물병원 및 지역 동물병원과 연계하여 Tumor organoid를 이용한 암 기전 및 치료 연구

• 분당서울대병원/충남대학교 의과대학/제주대학교 동물병원과 근육 오가노이드를 이용한 Fecal incontinence 재생 연구

PUBLICATIONS

58. Hwang I, Kim K, Ryu SH, Ahn C, Cui XS, Jeung EB. Data on the effect of wood-based panel-emitted volatile organic compounds on mice. Data Brief. 2025 Aug 6;62:111965. doi: 10.1016/j.dib.2025.111965. eCollection 2025 Oct.

57. Tonini L*, Ahn C*. Latest Advanced Techniques for Improving Intestinal Organoids Limitations. Stem Cell Rev Rep. 2025 Aug;21(6):1631-1647. doi: 10.1007/s12015-025-10894-9. Epub 2025 May 19.

56. Jang E*, Ahn C*. Comparative analysis of bisphenol A effects on HT-29 cell line and mouse intestinal organoids . J Biomed Transl Res. 2024 Aug;25(3):107-117. doi: 10.12729/jbtr.2024.25.3.107

55. Ryu MO*, Jung JY, Suh HN, Lee CY, Kim MC, Oh JY, Song WJ, Ahn C, Yang Y, Choi GE. Glucocorticoid-Dependent Retinal Degeneration and Vision Impairment in Mice Susceptible to Prenatal Stress-Induced Behavioral Abnormalities. Cell Mol Neurobiol. 2024 Dec 23;45(1):7. doi: 10.1007/s10571-024-01525-x.

54. Shin HS*, Lee SH, Moon HJ, So YH, Jang HJ, Lee KH, Ahn C, Jung EM. Prolonged stress response induced by chronic stress and corticosterone exposure causes adult neurogenesis inhibition and astrocyte loss in mouse hippocampus. Brain Res Bull. 2024 Mar;208:110903. doi: 10.1016/j.brainresbull.2024.110903. Epub 2024 Feb 15.

53. Hong S*, Kim J, Ahn M, Jung K, Moon C, Ahn C, Sanchez-Quinteiro P, Shin T. Key Genes in Olfactory Disorder in Experimental Autoimmune Encephalomyelitis Identified by Transcriptomic Analysis of the Olfactory Bulbs. Mol Neurobiol. 2024 Aug;61(8):5771-5786. doi: 10.1007/s12035-024-03923-0. Epub 2024 Jan 17.

52. Moon HJ*, Shin HS, Lee SH, Hong EJ, Ahn C, Yoo YM, Jeung EB, Lee GS, An BS, Jung EM. Effects of prenatal bisphenol S and bisphenol F exposure on behavior of offspring mice. Anim Cells Syst (Seoul). 2023 Oct 11;27(1):260-271. doi: 10.1080/19768354.2023.2264905. eCollection 2023.

51. Kang DH*, Kim MJ, Mohamed EA, Kim DS, Jeong JS, Kim SY, Kang HG, Lee GS, Hong EJ, Ahn C, Jung EM, An BS, Kim SC. Regulation of uterus and placenta remodeling under high estradiol levels in gestational diabetes mellitus models†. Biol Reprod. 2023 Aug 10;109(2):215-226. doi: 10.1093/biolre/ioad059.

50. Lee M*, Ahn C, Kim K, Jeung EB. Mitochondrial Toxic Effects of Antiepileptic Drug Valproic Acid on Mouse Kidney Stem Cells. Toxics. 2023 May 20;11(5):471. doi: 10.3390/toxics11050471.

49. Ahn C*, Jeong S*, Jeung EB. Mitochondrial dynamics when mitochondrial toxic chemicals exposed in 3D cultured mouse embryonic stem cell. Toxicol Res. 2022 Dec 13;39(2):239-249. doi: 10.1007/s43188-022-00161-1. eCollection 2023 Apr. *, equal contribution

48. Ahn C*, Jeung EB. Endocrine-Disrupting Chemicals and Disease Endpoints. Int J Mol Sci. 2023 Mar 10;24(6):5342. doi: 10.3390/ijms24065342.

47. Jeong S*, Ahn C*, Kwon JS, Kim K, Jeung EB. Effects of Sodium Arsenite on the Myocardial Differentiation in Mouse Embryonic Bodies. Toxics. 2023 Feb 1;11(2):142. doi: 10.3390/toxics11020142. *, equal contribution

46. Durga N*, Ahn C*, Yang YA, Lee GY,  Song J. Malnutrition and maternal vaccination against typhoid toxin. PLoS Pathogens, 2022 Aug 12;18(8):e1010731. *, equal contribution

45. Nguyen T*, Richards AF*, Neupane DP, Feathers JR, Yang YA, Sim JH, Byun H, Lee S, Ahn C, Van Slyke G, Fromme JC, Mantis NJ, Song J. The structural basis of Salmonella A2B5 toxin neutralization by antibodies targeting the glycan-receptor binding subunits. Cell Rep. 2021 Sep 7;36(10):109654

44. Ahn C*, Yang YA*, Neupane DP, Nguyen T, Richards AF, Sim JH, Mantis NJ, Song J. Mechanisms of typhoid toxin neutralization by antibodies targeting glycan receptor binding and nuclease subunits. iScience 2021 Apr 20;24(5):102454 *, equal contribution

43. Lee S, Yang YA, Milano SK, Nguyen T, Ahn C, Sim JH, Thompson AJ, Hillpot EC, Yoo G, Paulson JC, Song J. Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence. Cell Host & Microbe. 2020 Jun 10;27(6):937-949

42. Jung EM, Yoo YM, Park SY, Ahn C, Jeon BH, Hong EJ, Kim WY, Jeung EB. Calbindin-D9k is a Novel Risk Gene for Neurodegenerative Disease. Cell Physiol Biochem. 2020 May 2;54(3):438-456.

41. Lee JH, Park SY, Ahn C, Yoo YM, Kim CW, Kim JE, Jo NR, Kang HY, Jung EM, Kim KS, Choi KC, Lee SD, Jeung EB. Second-phase validation study of an alternative developmental toxicity test using mouse embryonic stem cell-derived embryoid bodies J Physiol Pharmacol. 2020 Apr;71(2)

40. Ahn C, Lee JH, Park MJ, Kim JW, Yang J, Yoo YM, Jeung EB. Cytostatic effects of plant essential oils on human skin and lung cells. Exp Ther Med. 2020 Mar;19(3):2008-2018.

39. Nguyen T, Lee S, Yang YA, Ahn C, Sim JH, Kei TG, Barnard KN, Yu H, Millano SK, Chen X, Parrish CR, Song J. The role of 9-O-acetylated glycan receptor moieties in the typhoid toxin binding and intoxication. PLoS Pathog. 2020 Feb 21;16(2):e1008336.

38. Ahn C*, Jung EM*, An BS, Hong EJ, Yoo YM, Jeung EB. The Protective Role of Calbindin-D9k on Endoplasmic Reticulum Stress-Induced Beta Cell Death. Int J Mol Sci. 2019 Oct 25;20(21). *, equal contribution

37. Choo HR, Kim H, Kang JH, Sung CJ, Ahn C, Kang BT, Chang D, Jeung EB, Yang MP. Effects of hydrocortisone administration on leptin and adiponectin synthesis in dogs. Am J Vet Res. 2019 Aug;80(8):771-778.

36. Lee B, Ahn C, Jeon BH, Jung EM, Yoo YM, Jeung EB. Regulatory effect of dexamethasone on tracheal calcium processing proteins and mucosal secretion J Physiol Pharmacol. 2019 Feb;70(1)

35. Lee SR, Kwon SW, Lee YH, Kaya P, Kim JM, Ahn C, Jung EM, Lee GS, An BS, Jeung EB, Park BK, Hong EJ. Dietary intake of genistein suppresses hepatocellular carcinoma through AMPK-mediated apoptosis and anti-inflammation. BMC Cancer. 2019 Jan 3;19(1):6.

34. Yoo YM, Jung EM, Ahn C, Jeung EB. Nitric oxide prevents H2O2-induced apoptosis in SK-N-MC human neuroblastoma cells. Int J Biol Sci. 2018 Nov 2;14(14):1974-1984.

33. Ahn C, Lee JH, Kim JW, Park MJ, Lee SS, Jeung EB. Alleviation effects of natural volatile organic compounds from Pinus densiflora and Chamaecyparis obtusa on systemic and pulmonary inflammation. Biomed Rep. 2018 Nov;9(5):405-414.

32. Lee JH, Park SY, Ahn C, Kim CW, Kim JE, Jo NR, Kang HY, Yoo YM, Jung EM, Kim EM, Kim KS, Choi KC, Lee SD, Jeung EB. Pre-validation study of alternative developmental toxicity test using mouse embryonic stem cell-derived embryoid bodies. Food Chem Toxicol, 2018 Oct;123:50-56.

31. Tran DN, Jung EM, Ahn C, Lee JH, Yoo YM, Jeung EB. Effects of Bisphenol A and 4-tert-Octylphenol on Embryo Implantation Failure in Mouse. Int J Environ Res Public Health. 2018 Jul 30;15(8).

30. Tran DN, Jung EM, Yoo YM, Ahn C, Kang HY, Choi KC, Hyun SH, Dang VH, Pham TN, Jeung EB. Depletion of follicles accelerated by combined exposure to phthalates and 4-vinylcyclohexene diepoxide, leading to premature ovarian failure in rats. Reprod Toxicol. 2018 Sep;80:60-67.

29. Ahn C, Kang HS, Lee JH, Hong EJ, Jung EM, Yoo YM, Jeung EB. Bisphenol A and octylphenol exacerbate type 1 diabetes mellitus by disrupting calcium homeostasis in mouse pancreas. Toxicol Lett. 2018 Oct 1;295:162-172.

28. Ahn C, Choi JS, Jeung EB. Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs. Mol Med Rep. 2018 Aug;18(2):1773-1781.

27. Kim HM, Ahn C, Kang BT, Kang JH, Jeung EB, Yang MP. Fucoidan suppresses excessive phagocytic capacity of porcine peripheral blood polymorphonuclear cells by modulating production of tumor necrosis factor-alpha by lipopolysaccharide-stimulated peripheral blood mononuclear cells. Res Vet Sci. 2018 Jun;118:413-418.

26. An JY, Ahn C, Kang HY, Jeung EB. Inhibition of mucin secretion via glucocorticoid-induced regulation of calcium-related proteins in mouse lung. Am J Physiol Lung Cell Mol Physiol. 2018 Jun 1;314(6):L956-L966.

25. Ahn C, Kang JH, Jeung EB. Calcium homeostasis in diabetes mellitus. J Vet Sci. 2017 Sep 30;18(3):261-266.

24. Lee JS, Ahn C, Kang HY, Jeung EB. Effect of 2-methoxyestradiol on SK-LMS-1 uterine leiomyosarcoma cells. Oncol Lett. 2017 Jul;14(1):103-110.

23. Kang HY, Choi YK, Jo NR, Lee JH, Ahn C, Ahn IY, Kim TS, Kim KS, Choi KC, Lee JK, Lee SD, Jeung EB. Advanced developmental toxicity test method based on embryoid body's area. Reprod Toxicol. 2017 Sep;72:74-85.

22. Kang HY, Hong EJ, Kang HS, Ahn C, Jeung EB. Assessment of neurotoxicity of pharmacological compounds during early neural development of human embryonic stem cells. J Physiol Pharmacol. 2017 Apr;68(2):231-241.

21. Yang H*, Ahn C*, Shin EK, Lee JS, An BS, Jeung EB. NCKX3 was compensated by calcium transporting genes and bone resorption in a NCKX3 KO mouse model. Mol Cell Endocrinol. 2017 Oct 15;454:93-102. *, equal contribution

20. Lee JH, Lee M, Ahn C, Kang HY, Tran DN, Jeung EB. Parabens Accelerate Ovarian Dysfunction in a 4-Vinylcyclohexene Diepoxide-Induced Ovarian Failure Model. Int J Environ Res Public Health. 2017 Feb 8;14(2). pii: E161.

19. Kim K, Lee D, Ahn C, Kang HY, An BS, Seong YH, Jeung EB. Effects of estrogen on esophageal function through regulation of Ca(2+)-related proteins. J Gastroenterol. 2017 Aug;52(8):929-939.

18. Ahn C, Lee D, Lee JH, Yang H, An BS, Jeung EB. Calbindin-D9k Ablation Disrupt Glucose/Pancreatic Insulin Homeostasis. PLoS One. 2016 Oct 13;11(10):e0164527.

17. Lee JH, Ahn C, Kang HY, Hong EJ, Hyun SH, Choi KC, Jeung EB. Effects of Octylphenol and Bisphenol A on the Metal Cation Transporter Channels of Mouse Placentas. Int J Environ Res Public Health. 2016 Sep 28;13(10). pii: E965.

16. Ahn C*, Shin DH*, Lee D, Kang SM, Seok JH, Kang HY, Jeung EB. Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs. Mol Med Rep. 2016 Oct;14(4):3697-703. *, equal contribution

15. Lee D, Ahn C, Hong EJ, An BS, Hyun SH, Choi KC, Jeung EB. 2,4,6-Tribromophenol Interferes with the Thyroid Hormone System by Regulating Thyroid Hormones and the Responsible Genes in Mice. Int J Environ Res Public Health. 2016 Jul 12;13(7). pii: E697.

14. Lee B, Kang HY, Lee DO, Ahn C, Jeung EB. Claudin-1, -2, -4, and -5: comparison of expression levels and distribution in equine tissues. J Vet Sci. 2016 Dec 30;17(4):445-451.

13. Lee D, Ahn C, An BS, Jeung EB. Induction of the Estrogenic Marker Calbindn-D₉k by Octamethylcyclotetrasiloxane. Int J Environ Res Public Health. 2015 Nov 17;12(11):14610-25.

12. Lee JS, Kim YK, Yang H, Kang HY, Ahn C, Jeung EB. Two faces of the estrogen metabolite 2-methoxyestradiol in vitro and in vivo. Mol Med Rep. 2015 Oct;12(4):5375-82.

11. Yang H, Jung EM, Ahn C, Lee GS, Lee SY, Kim SH, Choi IG, Park MJ, Lee SS, Choi DH, Jeung EB. Elemol from Chamaecyparis obtusa ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis. Int J Mol Med. 2015 Aug;36(2):463-72.

10. Ahn C, An BS, Jeung EB. Streptozotocin induces endoplasmic reticulum stress and apoptosis via disruption of calcium homeostasis in mouse pancreas. Mol Cell Endocrinol. 2015 Sep 5;412:302-8.

9. Ahn C, Yang H, Lee D, An BS, Jeung EB. Placental claudin expression and its regulation by endogenous sex steroid hormones. Steroids. 2015 Aug;100:44-51.

8. Yang H, Ahn C, Choi IG, Choi WS, Park MJ, Lee SS, Choi DH, Jeung EB. Estimation of the environmental effect of natural volatile organic compounds from Chamaecyparis obtusa and their effect on atopic dermatitis-like skin lesions in mice. Mol Med Rep. 2015 Jul;12(1):345-50.

7. Hong EJ, Choi Y, Yang H, Kang HY, Ahn C, Jeung EB. Establishment of a rapid drug screening system based on embryonic stem cells. Environ Toxicol Pharmacol. 2015 Jan;39(1):327-38.

6. Yang H, Ahn C, Jeung EB. Differential expression of calcium transport genes caused by COMT inhibition in the duodenum, kidney and placenta of pregnant mice.  Mol Cell Endocrinol. 2015 Feb 5;401:45-55.

5. Hwang I, Hong EJ, Yang H, Kang HS, Ahn C, An BS, Jeung EB. Regulation of tight junction gene expression in the kidney of calbindin-D9k and/or -D28k knockout mice after consumption of a calcium- or a calcium/vitamin D-deficient diet. BMC Biochem. 2014 Mar 15;15:6.

4. Hwang I, Yang H, Kang HS, Ahn CH, Lee GS, Hong EJ, An BS, Jeung EB. Spatial expression of claudin family members in various organs of mice. Mol Med Rep. 2014 May;9(5):1806-12.

3. Ahn C, Yang H, Hong EJ, Jeung EB. Regulation and localization of transient receptor potential melastatin 2 in rat uterus. Reprod Sci. 2014 Oct;21(10):1288-95.

2. Hwang I, Yang H, Kang HS, Ahn C, Hong EJ, An BS, Jeung EB. Alteration of tight junction gene expression by calcium- and vitamin D-deficient diet in the duodenum of calbindin-null mice. Int J Mol Sci. 2013 Nov 20;14(11):22997-3010.

1. Yang H, Hwang I, Kim S, Ahn C, Hong EJ, Jeung EB. Preventive effects of Lentinus edodes on homocysteinemia in mice. Exp Ther Med. 2013 Aug;6(2):465-468.

PATENTS

2.  Mi-Jin Park, Sung-Suk Lee, Eui-Bae Jeung, Ji-Yoon Yang, Jae-Woo Kim, Changhwan Ahn, Jae-Hwan Lee, Myeongho Lee. Composition for anti-inflammatory containing essential oil extract derived Pinus densifloa stem and method of manufacturing the extract  Int. CL A61K 36/15(2006.01.01) A61K 31/01(2006.01.01) A61K 8/97(2017.01.01) A61K 8/31(2006.01.01) A23L 33/105(2016.01.01) A61Q 19/00(2006.01.01)

1.  Sung-Suk Lee, Mi-Jin Park, Eui-Bae Jeung, In-Gyu Choi, Eui-Man Jung, Hyun Yang, Changhwan Ahn. Pharmaceutical composition for Atopic dermatitis  Int. CL A61K 31/045(2006.01.01) A61K 36/14(2006.01.01) A61K 8/34(2006.01.01) A61Q 19/00(2006.01.01) A23L 29/00(2016.01.01) C07C 29/74(2006.01.01)