There is also synthetic (man-made) caffeine, which is added to some medicines, foods, and drinks. For example, some pain relievers, cold medicines, and over-the-counter medicines for alertness contain synthetic caffeine. So do energy drinks and "energy-boosting" gums and snacks.
Energy drinks are beverages that have added caffeine. The amount of caffeine in energy drinks can vary widely, and sometimes the labels on the drinks do not give you the actual amount of caffeine in them. Energy drinks may also contain sugars, vitamins, herbs, and supplements.
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Companies that make energy drinks claim that the drinks can increase alertness and improve physical and mental performance. This has helped make the drinks popular with American teens and young adults. There's limited data showing that energy drinks might temporarily improve alertness and physical endurance. There is not enough evidence to show that they enhance strength or power. But what we do know is that energy drinks can be dangerous because they have large amounts of caffeine. And since they have lots of sugar, they can contribute to weight gain and worsen diabetes.
Sometimes young people mix their energy drinks with alcohol. It is dangerous to combine alcohol and caffeine. Caffeine can interfere with your ability to recognize how drunk you are, which can lead you to drink more. This also makes you more likely to make bad decisions.
Stimulant drugs speed up the nervous system. Caffeine and ephedrine are both stimulant drugs. Taking caffeine along with ephedrine might cause too much stimulation and sometimes serious side effects and heart problems. Do not take caffeine-containing products and ephedrine at the same time.
Caffeine might block the effects of adenosine. Adenosine is often used by doctors to do a test on the heart called a cardiac stress test. Stop consuming caffeine-containing products at least 24 hours before a cardiac stress test.
The body breaks down caffeine to get rid of it. Some antibiotics can decrease how quickly the body breaks down caffeine. Taking these drugs along with caffeine might increase the risk of side effects including jitteriness, headache, increased heart rate, and others.
The body breaks down caffeine to get rid of it. Cimetidine can decrease how quickly your body breaks down caffeine. Taking cimetidine along with caffeine might increase the chance of caffeine side effects including jitteriness, headache, fast heartbeat, and others.
The body breaks down clozapine to get rid of it. Caffeine seems to decrease how quickly the body breaks down clozapine. Taking caffeine along with clozapine can increase the effects and side effects of clozapine.
Caffeine might block the effects of dipyridamole. Dipyridamole is often used by doctors to do a test on the heart called a cardiac stress test. Stop consuming caffeine-containing products at least 24 hours before a cardiac stress test.
The body breaks down caffeine to get rid of it. Disulfiram can decrease how quickly the body gets rid of caffeine. Taking caffeine along with disulfiram might increase the effects and side effects of caffeine including jitteriness, hyperactivity, irritability, and others.
The body breaks down caffeine to get rid of it. Estrogens can decrease how quickly the body breaks down caffeine. Taking caffeine along with estrogens might increase the side effects of caffeine, including jitteriness, headache, and fast heartbeat.
The body breaks down caffeine to get rid of it. Fluvoxamine can decrease how quickly the body breaks down caffeine. Taking caffeine along with fluvoxamine might increase the effects and side effects of caffeine.
Caffeine can increase how quickly your body gets rid of lithium. If you take products that contain caffeine and you take lithium, don't stop taking caffeine products all at once. Instead, reduce use slowly. Stopping caffeine too quickly can increase the side effects of lithium.
There is some concern that caffeine can interact with certain medications, called MAOIs. If caffeine is taken with these medications, it might increase the risk for serious side effects including fast heartbeat and very high blood pressure.
Some common MAOIs include phenelzine (Nardil), selegiline (Zelapar), and tranylcypromine (Parnate).
Caffeine can stimulate the body. Phenylpropanolamine can also stimulate the body. Taking caffeine along with phenylpropanolamine might cause too much stimulation and increase heartbeat, blood pressure, and cause nervousness.
Stimulants, such as amphetamines and cocaine, speed up the nervous system. By speeding up the nervous system, stimulant medications can increase blood pressure and speed up the heartbeat. Caffeine can also speed up the nervous system. Taking caffeine along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure.
Caffeine works similarly to theophylline. Caffeine can also decrease how quickly the body gets rid of theophylline. Taking theophylline along with caffeine might increase the effects and side effects of theophylline.
Verapamil can decrease how quickly the body gets rid of caffeine. Taking caffeine along with verapamil can increase the risk of caffeine side effects including jitteriness, headache, and an increased heartbeat.
Ethosuximide is used to control certain types of seizures. Caffeine might lower the effects of ethosuximide. Taking caffeine with ethosuximide might reduce its effects and increase the risk of seizures.
The body breaks down flutamide to get rid of it. Caffeine might decrease how quickly the body breaks down flutamide. Taking caffeine along with flutamide might increase the effects and side effects of flutamide.
The body breaks down caffeine to get rid of it. Alcohol can decrease how quickly the body breaks down caffeine. Taking caffeine along with alcohol might increase the effects and side effects of caffeine, including jitteriness, headache, and fast heartbeat.
The body breaks down caffeine to get rid of it. Birth control pills can decrease how quickly the body breaks down caffeine. Taking caffeine along with birth control pills can cause jitteriness, headache, fast heartbeat, and other side effects.
The body breaks down caffeine to get rid of it. Fluconazole might decrease how quickly the body gets rid of caffeine. Taking caffeine along with fluconazole might cause caffeine to stay in the body too long and increase the risk of side effects such as nervousness, anxiety, and insomnia.
Caffeine can either increase or decrease blood sugar. Diabetes medications are used to lower blood sugar. Taking some medications for diabetes along with caffeine might change the effects of the diabetes medications. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Terbinafine can decrease how fast the body gets rid of caffeine. Taking caffeine along with terbinafine can increase the risk of caffeine side effects including jitteriness, headache, and increased heartbeat.
Caffeine is broken down mainly in the liver. It can remain in the blood anywhere from 1.5 to 9.5 hours, depending on various factors. [2] Smoking speeds up the breakdown of caffeine, whereas pregnancy and oral contraceptives can slow the breakdown. During the third trimester of pregnancy, caffeine can remain in the body for up to 15 hours. [3]
In the U.S., adults consume an average of 135 mg of caffeine daily, or the amount in 1.5 cups of coffee (1 cup = 8 ounces). [5] The U.S. Food and Drug Administration considers 400 milligrams (about 4 cups brewed coffee) a safe amount of caffeine for healthy adults to consume daily. However, pregnant women should limit their caffeine intake to 200 mg a day (about 2 cups brewed coffee), according to the American College of Obstetricians and Gynecologists.
The American Academy of Pediatrics suggests that children under age 12 should not consume any food or beverages with caffeine. For adolescents 12 and older, caffeine intake should be limited to no more than 100 mg daily. This is the amount in two or three 12-ounce cans of cola soda.
Caffeine is associated with several health conditions. People have different tolerances and responses to caffeine, partly due to genetic differences. Consuming caffeine regularly, such as drinking a cup of coffee every day, can promote caffeine tolerance in some people so that the side effects from caffeine may decrease over time. Although we tend to associate caffeine most often with coffee or tea, the research below focuses mainly on the health effects of caffeine itself. Visit our features on coffee, tea, and energy drinks for more health information related to those beverages.
Caffeine can block the effects of the hormone adenosine, which is responsible for deep sleep. Caffeine binds to adenosine receptors in the brain, which not only lowers adenosine levels but also increases or decreases other hormones that affect sleep, including dopamine, serotonin, norepinephrine, and GABA. [2] Levels of melatonin, another hormone promoting sleep, can drop in the presence of caffeine as both are metabolized in the liver. Caffeine intake later in the day close to bedtime can interfere with good sleep quality. Although developing a caffeine tolerance by taking caffeine regularly over time may lower its disruptive effects, [1] those who have trouble sleeping may consider minimizing caffeine intake later in the day and before going to bed.
In sensitive individuals, caffeine can increase anxiety at doses of 400 mg or more a day (about 4 cups of brewed coffee). High amounts of caffeine may cause nervousness and speed up heart rate, symptoms that are also felt during an anxiety attack. Those who have an underlying anxiety or panic disorder are especially at risk of overstimulation when overloading on caffeine.
Caffeine stimulates the heart, increases blood flow, and increases blood pressure temporarily, particularly in people who do not usually consume caffeine. However, strong negative effects of caffeine on blood pressure have not been found in clinical trials, even in people with hypertension, and cohort studies have not found that coffee drinking is associated with a higher risk of hypertension. Studies also do not show an association of caffeine intake and atrial fibrillation (abnormal heart beat), heart disease, or stroke. [3] ff782bc1db
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