The aim of the 2nd CA2V Workshop, as part of the IEEE ICVES 2018 conference, is to bring together researchers, professionals, policy makers, stakeholders and experts in vehicular electronics, active safety and protection systems, vehicular communications and IV/ITS related topics, to discuss and share she/he experience on current and future challenges of advanced safety technologies for connected and autonomous-automated vehicles (CAV). The CA2V theme is Advanced safety technologies for Autonomous Driving, emphasizing the current (on-going) and the next generation of safety and protection systems within a Connected-Cooperative Intelligent Transportation System (C-ITS) environment. Therefore, cooperative and multimodal sensor based advanced perception/protection systems, using artificial intelligence (AI) and/or machine learning (ML), will be particularly addressed in the 2nd CA2V International Workshop.