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Hydrocodone, also known as dihydrocodeinone, is a semi-synthetic opioid synthesized from codeine, one of the opioid alkaloids found in the opium poppy. It is a narcotic analgesic used orally for the relief of moderate to severe pain. In one study comparing the potency of hydrocodone to that of Oxycodone, it was found that it took 50% more hydrocodone to achieve the same degree of miosis. The investigators interpreted this to mean that Oxycodone is about 50% more potent than hydrocodone. Equal amount of either drug provided about the same degree of pain relief, indicating that there is little practical difference between them when used for that purpose. the analgesic action of hydrocodone begins in 20–30 minutes and lasts about 4–8 hours. Recommended dosing interval is 4–6 hours.

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• Take exactly as prescribed. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. An overdose can damage your liver or cause death. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

• Never take this medicine in larger amounts, or for longer than prescribed.  An overdose can damage your liver or cause death. Tell your doctor if the medicine seems to stop working as well in relieving your pain.​

• An overdose can damage your liver or cause death. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

• Common side effects include dizziness, sleepiness, nausea, and constipation. Serious side effects may include abuse, low blood pressure, seizures, QT prolongation, respiratory depression, and serotonin syndrome. Rapidly decreasing the dose may result in opioid withdrawal.

• Use during pregnancy or breastfeeding is generally not recommended. Hydrocodone is believed to work by activating opioid receptors, mainly in the brain and spinal cord. Hydrocodone 10 mg is equivalent to about 10 mg of morphine by mouth.

• Hydrocodone was patented in 1923 while the long-acting formulation was approved for medical use in the United States in 2013. In the United States, the wholesale cost of the long-acting formulation is about 10 to 30 USD per dose as of 2019.

• It is most commonly prescribed in the United States, which consumed 99% of the worldwide supply as of 2010. In 2016 it was the 113th most prescribed medication in the United States with more than 6 million prescriptions. It is made from the opium poppy after it has been converted to codeine.