Brandeis University's premier choral ensemble, the Brandeis Chamber Singers, is directed by Dr. Robert Duff. The singers in the Brandeis Chamber Singers are full-time, undergraduate music and non-music major students committed to innovative and quality performances and community outreach through choral music. Repertoire of the choir includes both a cappella and accompanied music from Western and Non-Western vocal traditions.

The Brandeis University Chorus is a larger mixed choir and includes members from the entire Brandeis community including undergraduate and graduate students, faculty and staff. It performs great and enduring music from the vast classic Western tradition, a cappella and accompanied. Student soloists from the Brandeis University Chorus are frequently featured. The University Chorus leads the community in the annual Messiah Sing every December in the Atrium of the Shapiro Student Center.