Publications

RNA transcripts serve as a template for double-strand break repair in human cells

Manisha Jalan, Alessandra Brambati, Hina Shah, Niamh McDermott, ... , Simon N. Powell & Agnel Sfeir 

Nature Communications. 2025 PMID: 40348775

RHINO directs MMEJ to repair DNA breaks in mitosis.

Brambati A*#, Sacco O*, Porcella S*, Heyza J, Kareh M, Schmidt J, Sfeir A#. 

Science. 2023 PMID: 37440612.

Elongating RNA polymerase II and RNA:DNA hybrids hinder fork progression and gene expression at sites of head-on replication-transcription collisions.

Zardoni L, Nardini E, Brambati A, Lucca C, Choudhary R, Loperfido F, Sabbioneda S, Liberi G. 

Nucleic Acids Resource. 2021 PMID: 34878142.

Polθ reverse transcribes RNA and promotes RNA-templated DNA repair.

Chandramouly G, Zhao J, McDevitt S, Rusanov T, Hoang T, Borisonnik N, Treddinick T, Lopezcolorado FW, Kent T, Siddique LA, Mallon J, Huhn J, Shoda Z, Kashkina E, Brambati A, Stark JM, Chen XS, Pomerantz RT. 

Science Advances. 2021 PMID: 34117057.

Senataxin Ortholog Sen1 Limits DNA:RNA Hybrid Accumulation at DNA Double-Strand Breaks to Control End Resection and Repair Fidelity.

Rawal CC, Zardoni L, Di Terlizzi M, Galati E, Brambati A, Lazzaro F, Liberi G, Pellicioli A. 

Cell Reports. 2020 PMID: 32375052.

The dark side of RNA:DNA hybrids.

Brambati A, Zardoni L, Nardini E, Pellicioli A, Liberi G. 

Mutation Research. 2020 PMID: 32430097. 

DNA polymerase theta (Polθ) - an error-prone polymerase necessary for genome stability.

Brambati A, Barry RM, Sfeir A. 

Current Opinion in Genetics & Development. 2020 PMID: 32302896. 

Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription.

Brambati A, Zardoni L, Achar YJ, Piccini D, Galanti L, Colosio A, Foiani M, Liberi G. 

Nucleic Acids Resource. 2018 PMID: 29059325. 

Replication and transcription on a collision course: eukaryotic regulation mechanisms and implications for DNA stability.

Brambati A, Colosio A, Zardoni L, Galanti L, Liberi G. 

Frontiers in Genetics. 2015 PMID: 25972894. 

Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes.

Alzu A, Bermejo R, Begnis M, Lucca C, Piccini D, Carotenuto W, Saponaro M, Brambati A, Cocito A, Foiani M, Liberi G. 

Cell. 2012 PMID: 23141540.

* co-first author

# co-corresponding author

Our publications can also be found at the National Library of Medicine, ORCID, and Google Scholar.