Due to the cortical plasticity of the brain, signals from implanted prostheses can, after adaptation, be handled by the brain like natural sensor or effector channels.[5] Following years of animal experimentation, the first neuroprosthetic devices implanted in humans appeared in the mid-1990s.

Recently, studies in human-computer interaction via the application of machine learning to statistical temporal features extracted from the frontal lobe (EEG brainwave) data has had high levels of success in classifying mental states (relaxed, neutral, concentrating),[6] mental emotional states (negative, neutral, positive),[7] and thalamocortical dysrhythmia.[8]


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Although the term had not yet been coined, one of the earliest examples of a working brain-machine interface was the piece Music for Solo Performer (1965) by the American composer Alvin Lucier. The piece makes use of EEG and analog signal processing hardware (filters, amplifiers, and a mixing board) to stimulate acoustic percussion instruments. To perform the piece one must produce alpha waves and thereby "play" the various percussion instruments via loudspeakers which are placed near or directly on the instruments themselves.[9]

In 1990, a report was given on a closed loop, bidirectional adaptive BCI controlling computer buzzer by an anticipatory brain potential, the Contingent Negative Variation (CNV) potential.[19][20] The experiment described how an expectation state of the brain, manifested by CNV, controls in a feedback loop the S2 buzzer in the S1-S2-CNV paradigm. The obtained cognitive wave representing the expectation learning in the brain is named Electroexpectogram (EXG). The CNV brain potential was part of the BCI challenge presented by Vidal in his 1973 paper.

Neuroprosthetics is an area of neuroscience concerned with neural prostheses, that is, using artificial devices to replace the function of impaired nervous systems and brain-related problems, or of sensory organs or organs itself (bladder, diaphragm, etc.). As of December 2010, cochlear implants had been implanted as neuroprosthetic device in approximately 220,000 people worldwide.[27] There are also several neuroprosthetic devices that aim to restore vision, including retinal implants. The first neuroprosthetic device, however, was the pacemaker.

Studies that developed algorithms to reconstruct movements from motor cortex neurons, which control movement, date back to the 1970s. In the 1980s, Apostolos Georgopoulos at Johns Hopkins University found a mathematical relationship between the electrical responses of single motor cortex neurons in rhesus macaque monkeys and the direction in which they moved their arms (based on a cosine function). He also found that dispersed groups of neurons, in different areas of the monkey's brains, collectively controlled motor commands, but was able to record the firings of neurons in only one area at a time, because of the technical limitations imposed by his equipment.[34]

There has been rapid development in BCIs since the mid-1990s.[35] Several groups have been able to capture complex brain motor cortex signals by recording from neural ensembles (groups of neurons) and using these to control external devices.

In 1999, researchers led by Yang Dan at the University of California, Berkeley decoded neuronal firings to reproduce images seen by cats. The team used an array of electrodes embedded in the thalamus (which integrates all of the brain's sensory input) of sharp-eyed cats. Researchers targeted 177 brain cells in the thalamus lateral geniculate nucleus area, which decodes signals from the retina. The cats were shown eight short movies, and their neuron firings were recorded. Using mathematical filters, the researchers decoded the signals to generate movies of what the cats saw and were able to reconstruct recognizable scenes and moving objects.[36] Similar results in humans have since been achieved by researchers in Japan (see below).

Miguel Nicolelis, a professor at Duke University, in Durham, North Carolina, has been a prominent proponent of using multiple electrodes spread over a greater area of the brain to obtain neuronal signals to drive a BCI.

After conducting initial studies in rats during the 1990s, Nicolelis and his colleagues developed BCIs that decoded brain activity in owl monkeys and used the devices to reproduce monkey movements in robotic arms. Monkeys have advanced reaching and grasping abilities and good hand manipulation skills, making them ideal test subjects for this kind of work.

Later experiments by Nicolelis using rhesus monkeys succeeded in closing the feedback loop and reproduced monkey reaching and grasping movements in a robot arm. With their deeply cleft and furrowed brains, rhesus monkeys are considered to be better models for human neurophysiology than owl monkeys. The monkeys were trained to reach and grasp objects on a computer screen by manipulating a joystick while corresponding movements by a robot arm were hidden.[38][39] The monkeys were later shown the robot directly and learned to control it by viewing its movements. The BCI used velocity predictions to control reaching movements and simultaneously predicted handgripping force. In 2011 O'Doherty and colleagues showed a BCI with sensory feedback with rhesus monkeys. The monkey was brain controlling the position of an avatar arm while receiving sensory feedback through direct intracortical stimulation (ICMS) in the arm representation area of the sensory cortex.[40]

John Donoghue's lab at the Carney Institute reported training rhesus monkeys to use a BCI to track visual targets on a computer screen (closed-loop BCI) with or without assistance of a joystick.[41] Schwartz's group created a BCI for three-dimensional tracking in virtual reality and also reproduced BCI control in a robotic arm.[42] The same group also created headlines when they demonstrated that a monkey could feed itself pieces of fruit and marshmallows using a robotic arm controlled by the animal's own brain signals.[43][44][45]

Miguel Nicolelis and colleagues demonstrated that the activity of large neural ensembles can predict arm position. This work made possible creation of BCIs that read arm movement intentions and translate them into movements of artificial actuators. Carmena and colleagues[38] programmed the neural coding in a BCI that allowed a monkey to control reaching and grasping movements by a robotic arm. Lebedev and colleagues[39] argued that brain networks reorganize to create a new representation of the robotic appendage in addition to the representation of the animal's own limbs.

In 2019, researchers from UCSF published a study where they demonstrated a BCI that had the potential to help patients with speech impairment caused by neurological disorders. Their BCI used high-density electrocorticography to tap neural activity from a patient's brain and used deep learning methods to synthesize speech.[48][49] In 2021, researchers from the same group published a study showing the potential of a BCI to decode words and sentences in an anarthric patient who had been unable to speak for over 15 years.[50][51]

The biggest impediment to BCI technology at present is the lack of a sensor modality that provides safe, accurate and robust access to brain signals. It is conceivable or even likely, however, that such a sensor will be developed within the next twenty years. The use of such a sensor should greatly expand the range of communication functions that can be provided using a BCI.

Invasive BCI requires surgery to implant electrodes under scalp for communicating brain signals. The main advantage is to provide more accurate reading; however, its downside includes side effects from the surgery. After the surgery, scar tissues may form which can make brain signals weaker. In addition, according to the research of Abdulkader et al., (2015),[57] the body may not accept the implanted electrodes and this can cause a medical condition.

Invasive BCI research has targeted repairing damaged sight and providing new functionality for people with paralysis. Invasive BCIs are implanted directly into the grey matter of the brain during neurosurgery. Because they lie in the grey matter, invasive devices produce the highest quality signals of BCI devices but are prone to scar-tissue build-up, causing the signal to become weaker, or even non-existent, as the body reacts to a foreign object in the brain.[58]

In vision science, direct brain implants have been used to treat non-congenital (acquired) blindness. One of the first scientists to produce a working brain interface to restore sight was private researcher William Dobelle.

Tetraplegic Matt Nagle became the first person to control an artificial hand using a BCI in 2005 as part of the first nine-month human trial of Cyberkinetics's BrainGate chip-implant. Implanted in Nagle's right precentral gyrus (area of the motor cortex for arm movement), the 96-electrode BrainGate implant allowed Nagle to control a robotic arm by thinking about moving his hand as well as a computer cursor, lights and TV.[65] One year later, professor Jonathan Wolpaw received the prize of the Altran Foundation for Innovation to develop a Brain Computer Interface with electrodes located on the surface of the skull, instead of directly in the brain.[66]

A report published in July 2021 reported a paralyzed patient was able to communicate 15 words per minute using a brain implant that analyzed motor neurons that previously controlled the vocal tract.[71][50]

In a recent review article, researchers raised an open question of whether human information transfer rates can surpass that of language with BCIs. Given that recent language research has demonstrated that human information transfer rates are relatively constant across many languages, there may exist a limit at the level of information processing in the brain. On the contrary, this "upper limit" of information transfer rate may be intrinsic to language itself, as a modality for information transfer.[72] 2351a5e196

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