Dr. Mainak Bose
Dr. Mainak Bose
Assistant professor
Department of Bioscience and Biotechnology
Indian Institute of Technology, Kharagpur, India
email: mainak29@iitkgp.ac.in
Postdoc: European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
PhD: CSIR-Indian Institute of Chemical Biology, Kolkata, India
Current Members
Sourav Dutta - the Nucleus
Project intern, Feb 2024 - Present
My project focusses on the 'Functional Regulation of Biomolecular Condensates in the Context of Drosophila Germline Development' where I am investigating the mechanism of membrane association of Long Oskar and the molecular underpinnings of two-dimensional phase separation in Drosophila germline development.
Parakbritta Hazra Dutta - the Droplet Detective
Post-MSc project intern, May, 2024 - Present
I explore the mechanistic basis of subcellular compartmentalization of biomolecular reactions by investigating the functional and organizational dynamics of membrane-assisted condensates and RNP granules in developing Drosophila oocytes.
I also develop novel expansion-based imaging methodologies to visualize RNP granules at nanoscale resolution, beyond the diffraction limit of conventional confocal microscope.
Denesh - the Lipid collector
PhD student, July, 2024 - Present
I study the mechanistic principles behind the formation of organelle contact sites and their role in lipid transfer between drug resistant Leishmania donovani and host lipid droplets.
Jeet Mukhopadhyay - the FISHerman
PhD student, January, 2025 - Present
I study translation regulation in membraneless biomolecular condensates in the context of germline development and axis specification of Drosophila embryos.
Sayan Roy - the Cloneman
Project intern, February, 2025 - Present
I study the molecular mechanism of endomembrane targeting of proteins coupled with membane-assisted phase separation.
Kajal Mondal -
PhD student, July, 2025 - Present
I study neuronal RNA binding protein condensates and their role in neuroprotection.
Sabina Khatun -
PhD student, July, 2025 - Present
I investigate the emerging role of RNA-RNA interactions in condensate formation and RNA localization.
Rachayita Das -
PhD student, July, 2025 - Present
I study the crosstalk of RNP granule condensates and the cellular microtubule cytoskeleton.
Subarna Dutta -
DST-WISE Postdoctoral fellow, February, 2025 - present
I am investigating the role of an RNA binding protein in the Drosophila germline and its interaction with the microtubule cytoskeleton.
Kalpa Chakraborty -
MSc intern, May, 2025 - Present
I develop in vitro assays to investugate the molecular basis of translation regulation in biomolecular condensates.
Subarna Moshan -
MTech intern, May, 2025 - Present
I study the effect of cytoplasmic crowding on RNP granule formation and dynamics using the vitellogenic Drosophila oocyte as a model.
Syamantak Dey - the Lipid laureate
Project intern, July, 2025 - Present
My work at the Laboratory of Biological Assemblies focuses on exploring how several proteins can form phase-separated condensates using lipid droplets as a substrate and how this phenomenon can be dynamically altered under different conditions of cell stress and starvation.
Past Members
Aniket Pan
May, 2025 - July 2025 ...Bachelor's internship
I was actively involved in cloning constructs for targetting a specific protein to the surface of Lipid droplets.
Debojit Saha
January, 2025 - April 2025...Master's internship
I was working on establishing an assay platform to investigate translation regulation in RNP granules.
Manacy Ramanan
January, 2025 - April 2025...Master's internship
I was investigating the role of an RNA binding protein in localization and translation of oskar mRNA.
Gourav Biswas
March, 2024 - December 2024
I was working on construction of tools to image translation in the fly oocytes.
Koushiki Basak
June, 2025 - July 2025...Master's internship
I was working on optimizing HCR-based in situ hybridization for RNA visualization in the fly germline.
Harshita Singh
January, 2025 - May 2025...Bachelor's internship
I was working on nanoscale visualization of RNP Granules beyond the Resolution Limit
Khushi Singh
May, 2025 - June, 2025...Bachelor's internship
I was working on optimizing single moelcule FISH techniques for RNA visualization in the fly germline.
Swomdeb Mondal
September 2024 - December 2024
I was working on generating transgenes for microinjection to investigate RNA-RNA interactions in fly germline.
Minakshi Bhattacharya
January, 2024 - June 2024...Master's internship
I was working on the effect of tissue-specific knockdown of translation regulators on oskar mRNA localization and translation in vivo
Niladri Narayan Mishra
January, 2024 - June 2024...Master's internship
I was working on the effect of tissue-specific knockdown of Protein kinase N on oskar mRNA localization and translation in vivo
Visitors
Antoine Giraud
July, 2025...EMBO Exchange fellow
I was working on expansion microscopy protocol developed by the Bose lab to apply it to adult Drosophila brains of different ages
Talented and motivated students, postdocs and interns interested in addressing fundamental questions in cell and developmental biology using genetics, imaging and biochemistry are encouraged to apply.
Please send a motivation letter along with a detailed CV to mainak29@iitkgp.ac.in