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I am a electronics engineer who loves to study everything related with photons and imaging. My doctoral research mainly involved deigning analog and digital circuit systems for high-accuracy opto-electronics and fiber systems. My research focuses on the design and implementation of novel biomedical imaging devices for high-resolution, multi-parametric, and multi-modal imaging in vivo and intraoperative. I currently work on design and commercialization of novel biomedical imaging modalities, including laser speckle contrast, fluorescence, polarimetric and 3D imaging.
I am a electronics engineer who loves to study everything related with photons and imaging. My doctoral research mainly involved deigning analog and digital circuit systems for high-accuracy opto-electronics and fiber systems. My research focuses on the design and implementation of novel biomedical imaging devices for high-resolution, multi-parametric, and multi-modal imaging in vivo and intraoperative. I currently work on design and commercialization of novel biomedical imaging modalities, including laser speckle contrast, fluorescence, polarimetric and 3D imaging.
Ph. D. in Electronics Engineering, Peking University 2013
Ph. D. in Electronics Engineering, Peking University 2013
Thesis: High-accuracy and long-distance information distribution via fiber networks
I investigated and successfully built an a novel and first-of-its kind system for ultrahigh-accuracy fiber communication, in which an analog & digital & optical method was used to reduce environmental noises.
Honors: Most Outstanding Graduate Student at Peking University, Most Outstanding Graduate Student of Overall Universities in Beijing, Wu Si Fellowship, Guang Hua Fellowship
B. S. in Electronics Engineering, Peking University 2008
B. S. in Electronics Engineering, Peking University 2008
Experience
Experience
Children's National Hospital, Vision & Robotics Lab, R&D Engineer
Children's National Hospital, Vision & Robotics Lab, R&D Engineer
I am currently developing new practical imaging modality to visualize important information which cannot be revealed by naked eyes, including polarimetric, 3D, fluorescence, laser speckle contrast, and hyperspectral imaging techniques. I successfully invented a novel polarimetric imaging tool for surgeries which achieved label-free and real-time nerving imaging for the first time. I am closely collaborating with surgeons with expertise on ENT, head & neck, GYN & urology and brain surgeries.
Johns Hopkins University, Research Fellow
Johns Hopkins University, Research Fellow
I was working on developing disposable medical endoscopy fro OCT and two-photon imaging. A miniaturized and portable probed was built to enable real-time imaging on freely-moving small rodents.
Honors: Kavli Fellowship
Polarimetric imaging on nerve
Fluorescence imaging on liver
laser speckle contrast imaging
Auto-fluorescence imaging on head & neck
Hyperspectral imaging on brain
University of Virginia, Research Associate
University of Virginia, Research Associate
I co-designed and developed the first-of-its-kind optical-acoustic systems for simultaneously angiography of vessel structure, oxygenation and blood flow down to single red blood cells. I have also been actively participating in the multiple cross-disciplinary collaborations, including realizing microscopic metabolic rate of oxygen measurement in stroke model, and multi-parametric microscopy of cortical vessel remodeling and responses to stroke in obese and diabetic mice. The research results have successfully led to winning UVA-AstraZeneca Strategic Alliance funding and more than 15 journal publications.
Skills
Skills
Altium Designer, C++, MATLAB, Labview, Zemax, Python
Selected Publications
Selected Publications
Design of novel intraoperative imaging devices for ENT, head & neck, GYN & urology and brain surgeries.
Design of novel intraoperative imaging devices for ENT, head & neck, GYN & urology and brain surgeries.
N. Kifle, S. Teti, B. Ning, D.A. Donoho, I. Katz, R. Keating, R. J. Cha, “Pediatric brain tissue segmentation using a snapshot hyperspectral imaging (sHSI) camera and machine learning classifier”, Bioengineering, vol. 10, pp. 1190, 2023.
M. S. Saruwatari, K. Jawed, K. M. Ali, B. Ning, S. Naik, S. Nam, M. J. Schnermann, A. D. Sandler, R. J. Cha, “Assessment of a novel biliary-specific near-infrared fluorescent dye (BL-760) for intraoperative detection of bile ducts and biliary leaks during hepatectomy in a preclinical swine model”, Lasers in Surgery and Medicine, vol. 55, pp. 480-489, 2023.
E. Oh, H. C. Lee, Y. Kim, B. Ning, S. Y. Lee, J. Cha, W. W. Kim, “A pilot feasibility study to assess vascularity and perfusion of parathyroid glands using a portable hand‐held imager”, Lasers in Surgery and Medicine, vol. 54, pp. 399-406, 2022.
B. Ning, W. W. Kim, I. Katz, C. H. Park, A. D Sandler, J. Cha, “Improved nerve visualization in head and neck surgery using mueller polarimetric imaging: preclinical feasibility study in a swine model”, Lasers in Surgery and Medicine, vol. 53, pp. 1472-1434, 2021.
Developing novel optical, ultrasound, and photoacoustic systems for high-resolution, multi-parametric, and multi-modal imaging
Developing novel optical, ultrasound, and photoacoustic systems for high-resolution, multi-parametric, and multi-modal imaging
B. Ning, N. Sun, R. Cao, R. Chen, K. K. Shung, J. A. Hossack, J.-M. Lee, Q. Zhou, S. Hu, “Ultrasound-aided multi-parametric photoacoustic microscopy of the mouse brain”, Scientific Reports, vol. 5, pp. 18775, 2015.
B. Ning, M. J. Kennedy, A. J. Dixon, N. Sun, R. Cao, B. T. Soetikno, R. Chen, Q. Zhou, K. K. Shung, J. A. Hossack, S. Hu, “Simultaneous Photoacoustic microscopy of microvascular anatomy, oxygen saturation, and blood flow”, Optics Letters, vol. 40, pp. 910-913,2015.
A. Li, G. Hall, D. Chen, W. Liang, B. Ning, H. Guan, X. Li, “A biopsy‐needle compatible varifocal multiphoton rigid probe for depth‐resolved optical biopsy”, Journal of Biophotonics, vol. 12, pp. e201800229, 2018.
Exploring vascular redistribution after plastic surgeries and various diseases using imaging techniques
Exploring vascular redistribution after plastic surgeries and various diseases using imaging techniques
P. S. Cottler, J. B. Olenczak, B. Ning, S. A. Seaman, J. M. Thuman, N. Sun, A. Piñeros-Fernandez, S. Hu, B. R DeGeorge Jr, C. A. Campbell, “Fenestration Improves Acellular Dermal Matrix Biointegration: An Investigation of Revascularization with Photoacoustic Microscopya”, Plastic and Reconstructive Surgery, online, 2019.
M. R. Kelly-Goss, B. Ning, A. C. Bruce, D. N. Tavakol, D.Yi, S. Hu, P.A. Yates, S. M. Peirce, “Dynamic, heterogeneous endothelial Tie2 expression and capillary blood flow during microvascular remodeling”, Scientific Reports, vol. 7, pp. 9049, 2017.
B. R. DeGeorge Jr., B. Ning, L. S. Salopek, A. Pineros-Fernandez, G. T. Rodeheaver, S. Peirce-Cottler, S. Hu, P. S. Cottler, C. A. Campbell, “Advanced imaging techniques for the investigation of acellular dermal matrix biointegration”, Plastic and Reconstructive Surgery, vol. 139, pp. 395-405, 2017.
Realizing microscopic metabolic rate of oxygen measurement using optical imaging modality in brain
Realizing microscopic metabolic rate of oxygen measurement using optical imaging modality in brain
R. Cao, J. Li, B. Ning, N. Sun, T. Wang, Z. Zuo, S. Hu, "Functional and Oxygen-metabolic Photoacoustic Microscopy of the Awake Mouse Brain", NeuroImage, vol. 150, pp. 77-87, 2017.
Study response to drugs using the imaging modalities
Study response to drugs using the imaging modalities
N. Sun, B. Ning, K. M. Hansson, A. C. Bruce, S. A. Seaman, C. Zhang, M. Rikard, C. A. DeRosa, C. L. Fraser, M. Wågberg, R. Fritsche-Danielson, J. Wikström, K. R. Chien, A. Lundahl, M. Hölttä, L. G. Carlsson, S. M Peirce, S. Hu, “Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing”, Scientific Reports, vol. 8, pp. 17509, 2018.
T. S. Keller Jr., J. T Butcher, G. B. Broseghini-Filho, C. Marziano, L. J. DeLalio, S. Rogers, B. Ning, J. N. Martin, S. Chechova, M. Cabot, X. Shu, A. K. Best, M. E. Good, A. S. Padilha, M. Purdy, M. Yeager, S. M. Peirce, S. Hu, A. Doctor, E. Barrett, T. H. Le, L.Columbus, B. E. Isakson, “Modulating vascular hemodynamics with an alpha globin mimetic peptide (HbαX)”, Hypertension, vol. 68, pp. 116.08171, 2016.
Imaging of functionalized nanoparticle contrasts
Imaging of functionalized nanoparticle contrasts
J. Song, F. Wang, X. Yang, B. Ning, M. G. Harp, S. H. Culp, S. Hu, P. Huang, L. Nie, J. Chen, X. Chen, “Gold nanoparticle coated carbon nanotube ring with enhanced Raman scattering and photothermal conversion property for theranostic applications”, Journal of the American Chemical Society, vol. 138, pp. 7005, 2016.
K. Song, P. Huang, C. Yi, B. Ning, S. Hu, L. Nie, X. Chen, Z. Nie, "Photoacoustic and colorimetric visualization of latent fingerprints," ACS nano, vol. 9, pp. 12344-12348, 2015.
Design of electric-optic system for ultra-stable laser and high-accuracy information transfer
Design of electric-optic system for ultra-stable laser and high-accuracy information transfer
B. Ning, S. Zhang, D. Hou, J. Wu, Z. Li, J. Zhao, “High-precision distribution of highly stable optical pulse trains with 8.8 X10-19 instability”, Scientific Reports, vol. 4, pp. 5109, 2014.
B. Ning, D. Hou, P. Du, J. Zhao, ”Long-term repetition frequency stabilization of passively mode-locked fiber laser using high-frequency harmonics synchronization”, IEEE Journal of Quantum Electronics, vol. 49, pp. 503-510, 2013.
B. Ning, T. Zheng, D. Hou, J. Zhao, ”Hybrid analog-digital fiber-based radio-frequency signal distribution”, IEEE Photonics Technology Letters, vol. 25, pp. 1551-1554, 2013.
B. Ning, P. Du, D. Hou, J. Zhao, ”Phase fluctuation compensation for long-term transfer of stable radio frequency over fiber link ”, Optics Express, vol. 20, pp. 28447-28454, 2012.
Simulation programs for studying complex-networked systems
Simulation programs for studying complex-networked systems
B. Ning, Q. Ren, J. Zhao, ”Enhancing consensus in weighted networks with coupling time-delay”, Physica A, vol. 391, pp. 3061-3068, 2012.
B. Ning, X. Yu, J. Hou, J. Zhao, ”Self-organization of directed networks through asymmetric coupling”, Physics Letters A, vol. 374, pp. 3739-3744, 2010.
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