Bo Ning, Ph.D. Electronics Engineer

I am a electronics engineer who loves to study everything related with photons and imaging. My doctoral research mainly involved deigning analog and digital circuit systems for high-accuracy opto-electronics and fiber systems. My current research focuses on the design and implementation of novel optical, ultrasound, and photoacoustic systems for high-resolution, multi-parametric, and multi-modal imaging. I have co-developed a first-of-its-kind multiparametric photoacoustic microscopy (PAM), which enables simultaneous imaging of microvascular anatomy, oxygensaturation, and blood flow down to the capillary level.

Ph. D. in Electronics Engineering, Peking University 2013

Thesis: High-accuracy and long-distance information distribution via fiber networks

I investigated and successfully built an a novel and first-of-its kind system for ultrahigh-accuracy fiber communication, in which an analog & digital & optical method was used to reduce environmental noises. The system suppressed the overall transmission noise to the lowest level of all the reported results before 2013.

Honors: Most Outstanding Graduate Student at Peking University, Most Outstanding Graduate Student of Overall Universities in Beijing, Wu Si Fellowship, Guang Hua Fellowship

B. S. in Electronics Engineering, Peking University 2008

Experience

Children's National Medical Center, Vision & Robotics Lab, R&D Engineer

I am currently developing new practical imaging modality to visualize important information which cannot be revealed by naked eyes, including 3D,fluorescent, laser speckle, and hyperspectral techniques. I am closely collaborating with surgeons with expertise on ENT, head & neck, GYN & urology and brain surgeries.



Johns Hopkins University, Research Fellow

I was working on developing disposable medical endoscopy fro OCT and two-photon imaging. A miniaturized and portable probed was built to enable real-time imaging on freely-moving small rodents.

Honors: Kavli Fellowship



University of Virginia, Research Associate

I co-designed and developed the first-of-its-kind optical-acoustic systems for simultaneously angiography of vessel structure, oxygenation and blood flow down to single red blood cells. I have also been actively participating in the multiple cross-disciplinary collaborations, including realizing microscopic metabolic rate of oxygen measurement in stroke model, and multi-parametric microscopy of cortical vessel remodeling and responses to stroke in obese and diabetic mice. The research results have successfully led to winning UVA-AstraZeneca Strategic Alliance funding and more than 15 journal publications.



Skills

Altium Designer, C, MATLAB, Labview, Python

Selected Publications

Developing novel optical, ultrasound, and photoacoustic systems for high-resolution, multi-parametric, and multi-modal imaging

B. Ning, N. Sun, R. Cao, R. Chen, K. K. Shung, J. A. Hossack, J.-M. Lee, Q. Zhou, S. Hu, “Ultrasound-aided multi-parametric photoacoustic microscopy of the mouse brain”, Scientific Reports, vol. 5, pp. 18775, 2015.

B. Ning, M. J. Kennedy, A. J. Dixon, N. Sun, R. Cao, B. T. Soetikno, R. Chen, Q. Zhou, K. K. Shung, J. A. Hossack, S. Hu, “Simultaneous Photoacoustic microscopy of microvascular anatomy, oxygen saturation, and blood flow”, Optics Letters, vol. 40, pp. 910-913,2015.

A. Li, G. Hall, D. Chen, W. Liang, B. Ning, H. Guan, X. Li, “A biopsy‐needle compatible varifocal multiphoton rigid probe for depth‐resolved optical biopsy”, Journal of Biophotonics, vol. 12, pp. e201800229, 2018.

Exploring vascular redistribution after plastic surgeries and various diseases using imaging techniques

P. S. Cottler, J. B. Olenczak, B. Ning, S. A. Seaman, J. M. Thuman, N. Sun, A. Piñeros-Fernandez, S. Hu, B. R DeGeorge Jr, C. A. Campbell, “Fenestration Improves Acellular Dermal Matrix Biointegration: An Investigation of Revascularization with Photoacoustic Microscopya”, Plastic and Reconstructive Surgery, online, 2019.

M. R. Kelly-Goss, B. Ning, A. C. Bruce, D. N. Tavakol, D.Yi, S. Hu, P.A. Yates, S. M. Peirce, “Dynamic, heterogeneous endothelial Tie2 expression and capillary blood flow during microvascular remodeling”, Scientific Reports, vol. 7, pp. 9049, 2017.

B. R. DeGeorge Jr., B. Ning, L. S. Salopek, A. Pineros-Fernandez, G. T. Rodeheaver, S. Peirce-Cottler, S. Hu, P. S. Cottler, C. A. Campbell, “Advanced imaging techniques for the investigation of acellular dermal matrix biointegration”, Plastic and Reconstructive Surgery, vol. 139, pp. 395-405, 2017.

Realizing microscopic metabolic rate of oxygen measurement using optical imaging modality in brain

R. Cao, J. Li, B. Ning, N. Sun, T. Wang, Z. Zuo, S. Hu, "Functional and Oxygen-metabolic Photoacoustic Microscopy of the Awake Mouse Brain", NeuroImage, vol. 150, pp. 77-87, 2017.

Study response to drugs using the imaging modalities

N. Sun, B. Ning, K. M. Hansson, A. C. Bruce, S. A. Seaman, C. Zhang, M. Rikard, C. A. DeRosa, C. L. Fraser, M. Wågberg, R. Fritsche-Danielson, J. Wikström, K. R. Chien, A. Lundahl, M. Hölttä, L. G. Carlsson, S. M Peirce, S. Hu, “Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing”, Scientific Reports, vol. 8, pp. 17509, 2018.

T. S. Keller Jr., J. T Butcher, G. B. Broseghini-Filho, C. Marziano, L. J. DeLalio, S. Rogers, B. Ning, J. N. Martin, S. Chechova, M. Cabot, X. Shu, A. K. Best, M. E. Good, A. S. Padilha, M. Purdy, M. Yeager, S. M. Peirce, S. Hu, A. Doctor, E. Barrett, T. H. Le, L.Columbus, B. E. Isakson, “Modulating vascular hemodynamics with an alpha globin mimetic peptide (HbαX)”, Hypertension, vol. 68, pp. 116.08171, 2016.

Imaging of functionalized nanoparticle contrasts

J. Song, F. Wang, X. Yang, B. Ning, M. G. Harp, S. H. Culp, S. Hu, P. Huang, L. Nie, J. Chen, X. Chen, “Gold nanoparticle coated carbon nanotube ring with enhanced Raman scattering and photothermal conversion property for theranostic applications”, Journal of the American Chemical Society, vol. 138, pp. 7005, 2016.

K. Song, P. Huang, C. Yi, B. Ning, S. Hu, L. Nie, X. Chen, Z. Nie, "Photoacoustic and colorimetric visualization of latent fingerprints," ACS nano, vol. 9, pp. 12344-12348, 2015.

Design of electric-optic system for ultra-stable laser and high-accuracy information transfer

B. Ning, S. Zhang, D. Hou, J. Wu, Z. Li, J. Zhao, “High-precision distribution of highly stable optical pulse trains with 8.8 X10-19 instability”, Scientific Reports, vol. 4, pp. 5109, 2014.

B. Ning, D. Hou, P. Du, J. Zhao, ”Long-term repetition frequency stabilization of passively mode-locked fiber laser using high-frequency harmonics synchronization”, IEEE Journal of Quantum Electronics, vol. 49, pp. 503-510, 2013.

B. Ning, T. Zheng, D. Hou, J. Zhao, ”Hybrid analog-digital fiber-based radio-frequency signal distribution”, IEEE Photonics Technology Letters, vol. 25, pp. 1551-1554, 2013.

B. Ning, P. Du, D. Hou, J. Zhao, ”Phase fluctuation compensation for long-term transfer of stable radio frequency over fiber link ”, Optics Express, vol. 20, pp. 28447-28454, 2012.

Simulation programs for studying complex-networked systems

B. Ning, Q. Ren, J. Zhao, ”Enhancing consensus in weighted networks with coupling time-delay”, Physica A, vol. 391, pp. 3061-3068, 2012.

B. Ning, X. Yu, J. Hou, J. Zhao, ”Self-organization of directed networks through asymmetric coupling”, Physics Letters A, vol. 374, pp. 3739-3744, 2010.