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The series is initially set in September 2005 in Okinawa City (Koza) on Okinawa Island near the US Kadena Air Base. Under the care of her adoptive family, the protagonist Saya Otonashi had been living the life of an anemic amnesiac, but otherwise ordinary schoolgirl. However, her happy life is shattered when she is attacked by a Chiropteran, a hematophagous bat-like creature that lives by feeding on human blood. Saya learns that she is the only one who can defeat them, as her blood causes their bodies to crystallize and shatter. Armed with her special katana, Saya embarks on a journey with her family, friends, allies, and her chevalier Haji, to rid the world of the Chiropteran threat and recover her identity. The course of the journey reveals the background history of the Chiropterans and Saya's mysterious past, which extends into the mid-19th century. Over the course of the series, Saya travels across the world from Japan to Vietnam, Russia, France, the United Kingdom, and finally the United States.

Blood pressure is the force of your blood pushing against the walls of your arteries. Each time your heart beats, it pumps blood into the arteries. Your blood pressure is highest when your heart beats, pumping the blood. This is called systolic pressure. When your heart is at rest, between beats, your blood pressure falls. This is called diastolic pressure.

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High blood pressure usually has no symptoms. So the only way to find out if you have it is to get regular blood pressure checks from your health care provider. Your provider will use a gauge, a stethoscope or electronic sensor, and a blood pressure cuff. He or she will take two or more readings at separate appointments before making a diagnosis.

When your blood pressure stays high over time, it causes the heart to pump harder and work overtime, possibly leading to serious health problems such as heart attack, stroke, heart failure, and kidney failure.

You will work with your provider to come up with a treatment plan. It may include only the lifestyle changes. These changes, such as heart-healthy eating and exercise, can be very effective. But sometimes the changes do not control or lower your high blood pressure. Then you may need to take medicine. There are different types of blood pressure medicines. Some people need to take more than one type.

Coronary artery disease is caused by the buildup of plaque in the walls of the coronary arteries, the blood vessels that supply oxygen and blood to the heart. Plaque is made of cholesterol deposits, which make the inside of arteries narrow and decrease blood flow. This process is called atherosclerosis, or hardening of the arteries. Decreased blood flow to the heart can cause a heart attack. Decreased blood flow to the brain can cause a stroke.

Your blood pressure, cholesterol levels, and weight will help your doctor understand your overall risk for heart disease. Your doctor may also recommend other tests to check your heart health, which could include:

Your ABO blood type is based on the presence or absence of the A and B antigens on your red blood cells. The A blood type has only the A antigen and the B blood type has only the B antigen. The AB blood type has both A and B antigens, and the O blood type has neither A nor B antigen.

By the time you are 6 months old, you naturally develop antibodies against the antigens your red blood cells lack. For instance, a person with A blood type will have anti-B antibodies, and a person with B blood type will have anti-A antibodies. If you have type A blood, you cannot receive B blood because your body's anti-B antibodies will fight the B blood's B antigens. It is crucial we have all blood types available to our patients.

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During her years at the Zoo, Saya was spoiled by the original Joel, and therefore became very immature, self-centered and rude. She herself realized this as a result of her friendships with Diva and Hagi, which help reveal and nurture her compassion for others. Overall, however, Saya was a bright, cheerful and innocent person. After she unwittingly released the vengeful, bloodthirsty Diva upon her foster family and friends and accidentally turned Hagi into her chevalier, coupled with learning the truth about her life and her own inhuman nature, Saya lost her happy demeanor and becomes much more serious and plagued with doubts and guilt.

As a result of losing her memories and spending a year in Okinawa as an ordinary girl, with family and friends, Saya develops a sweet and caring albeit somewhat reserved personality. Kai Miyagusuku later refers to her as being "a crybaby and a glutton". The latter name suits her as she is much inclined to eating. According to Kaori Kinj, no matter how much she eats, she never gets fat. The constant hunger is possibly due to insufficient consumption of blood. At this time, she is troubled by her amnesia, but only becomes increasingly insecure and worried as she learns more about her true identity and experiences more loss because of the Chiropterans.

Once she gets her memories back, Saya becomes broken and bitter, but gains a significant resolve to take down Diva no matter how long it takes or whatever the cost may be. She dedicates her life solely to correcting the mistake she made in releasing Diva by killing her, then forever ending the chiropteran threat by killing herself. She views killing Diva as her own personal task and refuses to let anyone else do it for her, not only because her blood is the only thing that can kill her, but also because she was the one who let Diva loose in the first place.

Saya is shown to have a bad habit of viewing the world in black-and-white; despite being one herself, she believes that any and all Chiropterans are evil and must be destroyed, due to the pain they had caused her and her adopted family. She also believes that Red Shield are simply fighting back against them and so aren't doing anything wrong and even accused Kai of making them look like the killers when he questioned this. Because of her biased hatred, Saya refuses to believe that the Schiff aren't evil even after learning that all they want is her blood, causing Kai to point out that, if all Chiropterans are enemies of humanity, then she, Hagi and Riku Miyagusuku (who had been turned into her chevalier) are as well. She also refuses to believe that Solomon had turned his back on Diva and joined her side, for no reason other than he's Diva's chevalier.

Saya first met Solomon during the school ball at Vietnam when she went undercover as one of its students. Despite being Diva's chevalier, Solomon fell in love with Saya. Because of this, Solomon often comes to Saya's rescue and declares that the bond he formed with her was beyond blood, because it is a path that he has chosen for himself. He denounced his connection to Diva and his fellow chevaliers and persuaded Saya to be his bride, promising her happiness, only for his affections to be rebuffed. He tried to kill Diva but failed and was kept in chains. After being set free by Nathan, he immediately saved Saya from James. Unfortunately he was too weak from blood loss due to his earlier fight with Diva and Saya's sword filled with her blood scraped him. He died a few minutes after leaving the scene, only to be witnessed by Amshel as he crystallized.

After the events in Vietnam, George was asked to look after Saya while she was in hibernation. He ended up putting her cocoon in the tomb where his family was buried and could only wait until she woke up. When she finally wake up, he decided to raise her as his daughter since she had lost her memory. Even though he knew how dangerous Saya was, George always claimed her as his daughter and was reluctant to let her go. During his transformation into a Chiropteran, George asked Saya to mix her blood with his so that he could die as her father. With his last words, George tell Saya to keep smiling, confront her past, and look forward to the future.

Strength: Although not to the extent of Diva's, Saya shows efficient strength in killing the chiropterans and Diva's chevaliers. Kai even calls her "a dragon slayer". But because she chooses not to feed freely on humans and refrains from drinking Hagi's blood as often as she can, her abilities barely matches that of Diva.

Power Gain: All queens require daily blood to stay healthy. Saya used to drink human blood in the guise of medicine made by Joel while she was in the Zoo. After waking up at Okinawa, she has regular blood transfusions too. As a queen, the intake of her chevalier's blood probably gives her more nutrition and has impact on her chiropteran power. After drinking his blood, she gains strength to fight as a chiropteran. Hagi's blood caused her untimely awakening and triggered her into berserk mode during Vietnam War. It also helps her regain memories.

Saya's trademark weapon is a special katana with a groove that branches out throughout the blade. Thus, when Saya cuts her thumb on the top edge of the katana, while gripping it so as to draw blood, the specially designed grooves allow her blood to flow into the channel and become distributed throughout the katana. Once loaded with her blood, it is a deadly weapon against Diva and any chiropteran of Diva's bloodline.

After Saya's first blade is broken in a fight with Amshel Goldsmith, David gives her a new one that has a red crystal at the base of its blade, which symbolizes her membership in the Red Shield organization. The crystal is a piece of George Miyagusuku's body, which is crystallized when she killed him with her own blood in order to spare him the fate of turning into a chiropteran. ff782bc1db