*Denotes undergraduate author
15. Lundin, P.M., Fiser, B.L., Blackledge, M.S., *Pickett, H.L., *Copeland, A.L. Functionalized Self-Assembled Monolayers: Versatile Strategies to Combat Bacterial Biofilm Formation, Pharmaceutics, 2022, 14, 1613. Link to Paper
14. *Viering, B., *Cunningham, T., *King, A., Blackledge, M.S., Miller, H.B. Brominated Carbazole with Antibiotic Adjuvant Activity Displays Pleiotropic Effects in MRSA’s Transcriptome, ACS Chemical Biology, 2022, 17 (5), 1239-1248. Link to Paper
13. *Berndsen, R., *Cunningham, T., *Kaelin, L., *Callender, M., *Boldog, W.D., *Viering, B., *King, A., *Labban, N., Pollock, J.A., Miller, H.B., Blackledge, M.S. Identification and evaluation of brominated carbazoles as a novel antibiotic adjuvant scaffold in MRSA. ACS Medicinal Chemistry Letters, 2022 . (ACS Editors' Choice Article) Link to Paper
12. *King, A., Blackledge, M.S. Evaluation of small molecule kinase inhibitors as novel antimicrobial and antibiotilm agents. Chemical Biology and Drug Design, 2021, 98, 1038. Link to Paper
11. *Gillard, K.R., *Ulrich, R.J., *Cutrona, N., *Seemann, M., Miller, H.B., Blackledge, M.S. From antihistamine to anti-infective: Loratadine inhibits regulatory PASTA kinases in Staphylococci to reduce biofilm formation and potentiate b-lactam antibiotics and vancomycin in resistant strains of S. aureus. ACS Infectious Diseases, 2019. Link to Paper
**See the highlight on this work in C&EN: Common allergy drug makes resistant bacteria vulnerable to antibiotics
10. *Gillard, K.R., Miller, H.B., Blackledge, M.S. Tricyclic Amine Antidepressants Suppress b-lactam Resistance in Methicillin-Resistant Staphylococcus aureus (MRSA) by Repressing mRNA Levels of Key Resistance Genes. Chemical Biology and Drug Design, 2018, 92 (5), 1822; doi: 10.1111/cbdd.13361 (Selected as Editor’s Choice Article) Link to Paper
9. *Wilson, T.J., Viguiera, P.A. Resensitization of methicillin-resistant Staphylococcus aureus by amoxapine, an FDA-approved antidepressant. Heliyon, 2018, 4 (1), e00501. Link to PDF
8. Robb, A., Vinogradov, S., Danell, A., Anderson, E., Blackledge, M.S., Melander, C., and Hvastkovs, E. Electrochemical Detection of Small Molecule Induced Biofilm Dispersion. Electrochimica Acta, 2018, 268, 276-282. Link to Paper
7. Garcia, S.S., Blackledge, M.S., Michalek, S., Su, L., Ptacek, T., Eipers, P., Morrow, C., Lefkowitz, E.J., Melander, C., and Wu, H. Targeting of Streptococcus mutans by a Novel Small Molecule Prevents Dental Caries and Preserves the Oral Microbiome. Journal of Dental Research, 2017. DOI: 0022034517698096 Link to PDF
6. Jeon, A., Obregon-Henao, A., Ackart, D., Podell, B., Belardinelli, J., Jackson, M., Nguyen, T., Blackledge, M.S., Melander, R.J., Melander, C., Johnson, B., Abramovitch, R., and Basaraba, R.J. 2-aminoimidazoles potentiate b-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing b-lactamase secretion and increasing cell envelope permeability. PLOS One, 2017, 12 (7), e0180925. Link to Paper (Open Access)
5. Nguyen, T.V., Blackledge, M.S., Lindsey, E.A., Minrovic, B.M., Ackart, D.F., Jeon, A.B., Obregon-Henao, A., Melander, R.J., Basaraba, R.J., and Melander, C. The Discovery of 2-Aminobenzimidazoles that Sensitize M. smegmatis and M. tuberculosis to b-Lactam Antibiotics in a Pattern Distinct from b-Lactamase Inhibitors. Angewandte Chemie, 2017, 56 (12), 3940-44. (Designated as a “hot paper”) Link to Paper
4. Stowe, S.D., Thompson, R.J., Peng, L., Su, Z., Blackledge, M.S., Coe, W.H., Johannes, E., Lapham, V.K., Mackenzie, J., Melander, C., and Cavanagh, J. Membrane-Permeabilizing Activity of Reverse-Amide 2-Aminoimidazole Antibiofilm Agents Against Gram-Negative Pathogen, Acinetobacter baumannii. Current Drug Delivery, 2015, 12 (2), 223-30. Link to PDF
3. Worthington, R.J., Blackledge, M.S., and Melander, C. Small Molecule Inhibition of Bacterial Two-Component Systems to Combat Antibiotic Resistance and Virulence. Future Medicinal Chemistry, 2013, 5 (11), 1265-1284. Link to Paper
2. Blackledge, M.S., Worthington, R.J., and Melander, C. Biologically-Inspired Strategies for Combating Bacterial Biofilms. Current Opinion in Pharmacology, 2013,13 (5), 699-706. Link to PDF
1. Blackledge, M.S. and Melander, C. Programmable DNA-binding Small Molecules. Bioorganic and Medicinal Chemistry, 2013, 21 (20), 6101-14. Link to PDF