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Professional Training and Research Experiences
With a good foundation of chemistry at my graduate, I joined at Indian Institute of Technology, kharagpur for my post-graduate studies on the year 2004. During my post-graduate studies, I have learned to perform different type of reactions in laboratory classes. From the second semester I have received an opportunity to join as a masters project fellow under the supervision of Prof. Tarun K Sarkar at IIT Kharagpur. In his supervision and with an appreciable guidance of senior labmates, I have learned lot of experimental techniques and knowledge about synthetic organic chemistry. My master project was focused on the synthesis of optically pure conformationally restricted nicotine analogues. After finishing my masters in 2006, I have joined again in Prof. Tarun K. Sarkars group at IIT Kharagpur. My doctoral work from the year of 2006 to 2012 was centres around the keywords like, total synthesis of natural products, Xyloketals, gold catalysis, methodology developments, Cross-coupling reactions (Suzuki, Sonogashira, Heck, Kumada, Negishi), metal catalysts and metal complex preparation (specially phosphine and N-Heterocyclic Carbene complexes), Bimetallic catalysis, heterocyclic chemistry, cross-coupling of diazonium salts etc. I have published eight international journals based on my doctoral work.
After my Ph.D, I have joined in National Taiwan University (NTU) on March, 2013 under the supervision of Prof. Tien-Yau Luh. My post-doctoral work focused mainly in the synthesis of ladderphanes polymers, conducting polymers having strong photophysical properties, cyclopropene based ladderphanes polymers and low polydisperse polyamides, etc. I have prepared the low disperse polyamide efficiently and this work will be published soon. Currently I am doing the synthesis of cyclopropene based laddarphanes and already got some interesting results on the polymerization using schrock’s catalyst. This work will also be submitted for publication shortly.
About ten years research experience in the field of organic synthesis, I have expertise in target-oriented multistep organic synthesis. I have also proficient in performing low temperature reactions, handling of air and moisture sensitive reagents and reactions. I am able to carry out organic transformations on milligram to multigram scale efficiently. I am also able to synthesis, purification and characterization of different polymers. I am also familiar to run NMR, IR, HRMS, HPLC, GPC, TGA, DSC, Polarimeter, UV-VIS spectrometers, sonicator, centrifuge, photochemistry operator, fluorescence spectrometer, etc.
I have a strong software knowledge and familiar with windows xp, windows 2000, Microsoft office, Chem. Draw, ISIS draw, Microsoft power point, Microsoft word, excel, pdf, Origin for graph plotting, Scifinder, Chem Draw 3D, minimum energy calculation, etc. I am also familiar to use of high end computational resources like gel permeation chromatography (GPC) and HPLC etc.
I am a self-motivated, hard working and dedicated person. I personally would like to be involved in teaching and as well as in modern scientific research. To succeed in this purpose, I will rely on my educational background in synthetic organic as well as organometallic chemistry and polymer chemistry with my experiences in past researches. I believe that my passion, creativity and the ability to work independent as well as in groups are the qualities which will lead me to become a successful person both in teaching and research.
Research
Research
Our program is broadly based on modern synthetic chemistry. We are developing synthetic tools (reactions and reagents) and networks of reactions (synthetic strategies) for efficient and selective chemical synthesis. In particular, we focus on the development of chemical transformations that can resolve longstanding synthetic problems and offer new mechanistic vistas for future development in organic synthesis.
Photoredox Catalysis in Organic Chemistry
Photoredox Catalysis in Organic Chemistry
Photochemical reactions are intriguing from a synthetic perspective because the stereochemistry, regiochemistry, and chemoselectivity of organic reactions can differ dramatically under conditions of either thermal or photochemical activation. Yet organic chemists have long been reluctant to use photochemical reactions in complex molecule synthesis, and the properties of the structures that are uniquely accesible using photochemical activation have thus been relatively unexplored. A central goal of our research is to develop photochemical methods that can conveniently be conducted by any synthetic organic chemist, using sources of visible light that are already present in a standard chemistry lab. We focus upon the photoactivity of the transition metal chromophores that have been extensively exploited in the design of technologies for solar energy conversion. We have found that complexes such as [Ru(bpy)3]2+ and its derivatives can also be used to photochemically activate organic molecules towards a wide range of synthetically useful transformations.
Combining Concepts
Combining Concepts
From solar cells and biofuels to pharmaceuticals and polymers, organometallic reactions play key roles. We develop single-molecule tools to study organic and organometallic reactions to provide fundamental understanding of the reaction steps in catalytic systems, and we develop dual-catalyst systems with applications in synthetic organic chemistry. These projects are inherently interdisciplinary and combine concepts from the traditional subdisciplines in chemistry.
Gold and Palladium Combined
Gold and Palladium Combined
A highly efficient gold and palladium combined methodology for the Sonogashira coupling of a wide array of electronically and structurally diverse aryl and heteroaryl halides were reported from our group. The orthogonal reactivity of the two metals shows high selectivity and extreme functional group tolerance in Sonogashira coupling. A brief mechanistic study reveals that the gold-acetylide intermediate enters into palladium catalytic cycle at the transmetalation step.
Use of arenediazonium in Sonogashira Coupling
Use of arenediazonium in Sonogashira Coupling
Arenediazonium salts have been reported as an alternative to aryl halides for the Sonogashira coupling reaction. Gold(I) chloride has been used as co-catalyst combined with palladium(II) chloride in the coupling of arenediazonium salts with terminal alkynes, a process carried out in the presence of bis-2,6-diisopropylphenyl dihydroimidazolium chloride (IPr NHC) (5 mol%) to in situ generate a NHC–palladium complex, and 2,6-di-tert-butyl-4-methylpyridine (DBMP) as base in acetonitrile as solvent at room temperature. This coupling can be carried out starting from anilines by formation of the diazonium salt followed by in situ Sonogashira coupling, where anilines are transformed into diazonium salt and furtherly converted into alkyne by coupling with phenylacetylene.
Synthesis of Target Molecules
Synthesis of Target Molecules
As synthetic chemists, we are inspired by the beauty of structurally complex natural products and by the need to produce complex pharmaceutical compounds using ever cleaner and more efficient synthetic processes. Target-oriented synthesis, therefore, is an important goal of our research, both as a benchmark by which to test the methods developed in our laboratory and as an inspiration that guides our research program.
A new and efficient one-pot desilylation−goldcatalyzed cycloisomerization of alkynes containing a silyl-protected phenolic −OH and a free alcoholic −OH unit leads selectively to the formation of tetrahydrofuranobenzopyran ring system. This approach has been used for the regio- and stereoselective synthesis of xyloketal D, xyloketal G, and the related natural product alboatrin.
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