BIOTHERA-Lab

Biomaterials For Theranostic Applications


University of Granada

Research

The BIOTHERA-Lab, established in 2021, is dedicated to the development of nanomaterials and biomaterials for therapeutic and diagnostic applications. Cell membrane-coated nanoparticles, graphene-based materials, and biopolymer scaffolds play a central role in several research lines carried out by the group. Our interest is also focused on a more basic research line that aims to elucidate the molecular and cellular mechanisms of bionanointeractions, ranging from biomolecular corona formation to intracellular nanoparticle trafficking. 

 MAIN RESEARCH LINES: 

Biomimetic nanoparticles for tumor targeting 

The emerging technology of cell membrane coating has become a novel concept for designing NPs, and it has been leveraged to significantly enhance the functionality of nanoparticulate platforms. In this lab, our goal is to design cell membrane coating nanosystem as a potential tool for cancer treatment and understand the benefits and drawbacks of this type of stealth coating by using well-established and reliable physicochemical characterization techniques

Bionanointeractions 

In our laboratory, we specialize in nanomedicine research, with a specific focus on the study of nanobiointeractions. We explore the application of nanotechnologies for the development of innovative approaches in the diagnosis and treatment of diseases, placing particular emphasis on understanding the intricate interactions at the nanoscale between designed materials and biological systems. Our objective is to contribute to the advancement of science and medicine by gaining a detailed understanding of nanoscale interactions, thereby providing a solid foundation for the design of more effective and precise therapies and diagnostics.


3D scaffolds for theranostics 

Dedicated to cutting-edge research, our focus extends to the exploration of 3D scaffolds for theranostics. Here, in collaboration with colleagues we actively develop and investigate innovative three-dimensional structures such as microgel platforms and magnetic hydrogels designed for theranostic applications and tissue regeneration.

Graphene based materials in neurosciences

In the realm of neuroscience, our research endeavors are prominently directed towards the exploration of graphene-based materials. These materials exhibit exceptional properties, ranging from high electrical conductivity to biocompatibility, making them ideal candidates for various neuroscientific applications, such as neural interfacing, biosensing, and therapeutic interventions. Our commitment lies in advancing the understanding and harnessing the potential of graphene-based materials to propel innovations in neuroscience research and applications. 

Transport of nanomaterials through biological barriers

Within the realm of nanomedicine, our research is dedicated to understanding the processes involved in the transport of nanomaterials through biological barriers. This involves a comprehensive exploration of the dynamic interplay between different nanomaterials and models of biological barriers including the blood-brain barrier and the intestinal barrier, seeking to understand the factors influencing their transport efficiency and potential applications.