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Welcome to our laboratory, where we delve into the intricate mechanisms of social behavior and uncover the causes and treatments for neurodevelopmental disorders, including autism spectrum disorder and epileptic encephalopathy. Utilizing advanced mouse models and human patient tissue, our research aims to pioneer new understandings and innovative therapies in the field.
Social information processing in the brain
1. Normal social information processing
2. Pathological social information processing
esp. autism model, the social stress model
Mechanism of immune contribution to the Autism
1. Peripheral and central immune profiling in the autism model
2. Cortical dysplasia as a pathognomic finding
3. Microbiome contribution to brain function
Autism Spectrum Disorder
Autism Spectrum Disorder
is a neurodevelopmental disorder that has social dysfunction and stereotyped and fixed interest and behavior. With many genetic mouse models, we are studying the pathophysiological mechanism and therapeutic intervention using numerous behavior tests, neuroimmunology, and in vivo electrophysiology.
Social Behavior
Social Behavior
is a very complex and instantaneous behavior requiring integrated brain activity. We are studying normal and abnormal social behavior in mice using genetic autism animal models. Ultimately, we want to find out how to improve social function with biological intervention.
Monogenic autism mice model
Monogenic autism mice model
We are using mice models with human-relevant, top-ranked autism gene mutations for studying pathophysiological mechanisms and treatment including neuro-immune involvement in autism spectrum disorder.
In vivo electrophysiology
In vivo electrophysiology
We are using in vivo single-unit recording, neuropixels recording, and Ca2+ imaging in freely behaving mice. We want to find the direct neuronal substrates for the behavior.
DeepLabCut
DeepLabCut
To deal with non-structural social behavior between multiple subjects, we applied 'Deeplabcut' (Open source, www.deeplabcut.org) to analyze mice behavior. We are getting huge benefits from the 'open-science' (www.openephys.org). We hope we can contribute to open science in near future.
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