Research

PK/PD of Next-Generation Therapeutics: Beyond Small Molecules

We investigate the pharmacokinetic and pharmacodynamic (PK/PD) properties of diverse therapeutic modalities—from conventional small molecules to peptides (e.g., GLP-1 receptor agonists) and nucleic acid-based drugs (e.g., oligonucleotides). 

Using sensitive LC-MS/MS bioanalytical methods, we characterize their complex PK behaviors. 

Model-Informed Drug Development: Mechanistic Modeling to AI-Driven Prediction 

We leverage cutting-edge modeling and simulation approaches—spanning population PK, PBPK, IVIVC, and emerging AI-based methods—to explain and predict drug behavior across development stages. 

These model-informed strategies are applied to support rational drug development and optimized formulation design. 

Advanced Drug Formulations using 3D Printing Technology

We design and develop modular 3D-printed drug delivery systems in which capsule units with distinct release-controlling functions are combined to achieve tailored, programmable drug release profiles. This platform enables flexible customization across a range of drugs, supporting the translation toward patient-centric, precision formulations.