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You will learn
You will learn
1. Production of therapeutic proteins
• Production of recombinant proteins in prokaryotes
• Hybridomas, phage display
• Candidate screening
• Antibodies and antibody-drug conjugates
• Epitope mapping
2. Quality control methodologies
• Glycan and glycopeptide analysis
• Analytical techniques in biotherapeutics production
• Bioequivalence assessment
• Host cell protein analysis
3. Mass spectrometry in biotherapeutics quality control
• ESI/MALDI for protein molecular ionization
• Intact mass profile and deconvolution
• Top-down and bottom-up MS
• Sequence variants
• Size and charge variants analysis
• Forced degradation studies
• Disulfide bond linkages
4. Other topics
• Intellectual property protection
• Immunopeptidomics
you will practice
you will practice
• Preparation of samples for LC/MS/MS
• Intact protein analysis by MS.
• Peptide purification.
• Mass spec setup and injection.
• Analysis of disulfide linkages and other PTMs
• Data collection and interpretation.
Schedule
Schedule
⚠️ Please note ⚠️
The schedule may be subject to minor adjustments in the coming weeks. Lecture titles currently listed reflect the intended content but are not necessarily the final titles.
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