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Research Goals
Research Goals
We study functional biological nanoparticles that encapsulate nucleic acids. These include natural systems, such as viruses, as well as engineered platforms designed for nucleic acid delivery, such as lipid nanoparticles (LNPs).
Our focus is on understanding their molecular interactions at the membrane interface and how these interactions govern key biological outcomes—namely, cellular infection in the case of viruses and gene delivery in the case of LNPs.
Insights from these studies are critical for translational applications, including the rational development of antiviral therapeutics, the design of safer vaccine candidates, and the advancement of effective gene therapy strategies.
Virus-Glycan Interactions
We examine molecular interactions of Enveloped Viruses with Glycolipids at Membrane Interfaces
We perform Fluorescence Imaging of Single Virus Particles
Viral Proteins and Mimics
We express viral proteins and design viral mimics
Cellular attachment, binding kinetics/dynamics, and entry of viral proteins and mimics are studied using model membranes such as Supported lipid bilayers (SLBs), Supported membrane bilayers (SMBs), and Giant vesicles (GUVs and GPMVs)
pDNA-LNPs and mRNA-LNPs
We formulate pDNA and mRNA-LNPs for effective gene delivery
We design DNA and synthesise mRNA
We image the cellular transport of the LNPs and Organ-targeting
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