Research  

High Intensity Focused Ultrasound  (HIFU)

• High-Intensity Focused Ultrasound (HIFU) is a non-invasive ultrasound technique which can be used to thermally necrose or mechanically ablate tumours at the HIFU focus without disruption to surrounding tissue. 

• The basic principle behind the use of HIFU involves focusing an ultrasound beam and delivering acoustic energy into a small region of interest within the body. This leads to localised heating and protein denaturation which cause irreversible tissue damage. 

Low Intensity Focused Ultrasound (LIFU)

• Low-Intensity Focused Ultrasound (LIFU) is a promising method of non-invasive neurmodulation which employs mechanical energy (ultrasound) to affect neuronal excitability.

HIFU Mechanical tissue fractionation 

• HIFU can also be used to result in mechanical tissue destruction via acoustic cavitation.

• Shock scattering histotripsy & Boiling histotripsy & Pressure-modulated shockwave histotripsy

• Soft tissue / solid tumour fractionation (In vitro, Ex vivo and In vivo)

• Sono-decellularisation

• Sono-thrombolysis

• Development of a histotripsy device

HIFU-induced acoustic cavitation

• Cavitation monitoring technique - stable vs. inertial cavitation

• Mathematical modelling of bubble dynamics 

• Ultrasound imaging