Molecular Biology
The first attachment provides Dr. Mark Goulian's PowerPoint presentation on promoters.
The second and third attachments provide the student handout and teacher notes for the hands-on activity "Cookie-ase". In this activity, students explore the effects of different types of point mutations and deletion mutations and analyze the reasons why deletion mutations generally have more severe effects than point mutations. Students enact different versions of the hypothetical cookie-ase enzyme to simulate the effects of different types of mutations on enzyme function. Finally, students use their understanding of mutations to analyze the genetic basis for the differences in severity of two cases of albinism and two types of muscular dystrophy; this section includes the concepts of homozygous, heterozygous, dominant, recessive and X-linked genes.