Overview of TCA

Steps 💡

1. Acetyl CoA + Oxaloacetate → Citrate + CoA-SH

ENZYME: Citrate Synthase 

2. Citrate → Isocitrate 

ENZYME: Aconitase 

3. Isocitrate → alpha-Ketogluterate + CO2 + NADH

ENZYME: Isocitrate dehydrogenase 

4. alpha-Ketogluterate → Succinyl-CoA + CO2 + NADH

ENZYME: alpha-Ketogluterate dehydrogenase COMPLEX 

5. Succinyl-CoA → Succinate + CoA + ⚡GTP⚡

ENZYME: Succinyl-CoA Synthetase 

6. Succinate → Fumarate + FADH2

ENZYME: Succinate dehydrogenase 

7. H2O + Fumarate → L-Malate 

ENZYME: Fumarase 

8. Malate → Oxaloacetate + NADH

ENZYME: malate dehydrogenase 

TOTAL YIELD: 

2 GTP were generated → 2 ATP

6 NADH will indirectly produce → 15 ATP

2 FADH2 will indirectly produce → 3 ATP

=20 ATP produced (only 2 directly…)