Phase 2: Oxidative Phase

Phase 2: Oxidative Phase

• This phase produces NADH and CO2 from both reactions

1. Isocitrate → alpha-Ketogluterate + CO2 + NADH

ENZYME: Isocitrate dehydrogenase 

• Inhibited by→ ATP, NADH

• Activated by → ADP and Ca2+ (Why? → Ca2+ is around after muscle contraction) 

2. alpha-Ketogluterate → Succinyl-CoA + CO2 + NADH

ENZYME: alpha-Ketogluterate dehydrogenase COMPLEX (this is the same structure as found in the PDH and functions the same) 

• Inhibited by: Succinyl-CoA, ATP, NADH