The names of these let you know what it does!Ā
1. Covalent catalysis: This is where the active site has a nucleophile that is modified by a covalent bond.Ā
- Remember, it is not permanently covalently modified, only for the substrate to be transformed to product!Ā
2. General Acid-Base Catalysis: Residue donates or accepts a proton
- Stabilizes transition state!Ā
3. Metal Ion Catalysis: Metal ion stabilizes a negative chargeĀ
4. Orientation: Enzymes bind and orient 2 substrates in a way that lowers activation energy.