Irreversible Inhibition

Memory Hack💡

The names do a great job of reminding you what they are! Try and use reasoning to think of what each could do just based off of their name. 

Notes

This section is shorter as it is solely memorization. 

1. Group specific: Like their names suggest, they target one specific amino acids R group

2. Affinity labels: These look like the substrate but actually covalently bind to the active site 

3. Mechanism-Based: The enzyme goes to process it like it was a substrate, but during the process, the inhibitor ends up creating an intermediate (i.e. why it is “mechanism based”) that irreversibly binds the substrate. 

4. Transition State Analog: Like the name suggests, this mimics the enzyme's transition state and binds to it even tighter than the substrate. 

-Reminder: this is NOT covalent like the others. It is irreversible due to interactions.