ATP/ADP Translocase

Notes

Due to the fact that ATP is made in the matrix and used in the cytosol, it is important that there is a way to shuttle ATP and then ADP (onced used) to and from the matrix. 

1. ADP enters the translocase when it is facing the cytosol. 

2. Due to its binding, the translocase flips to matrix (resupply with ADP) 

3. ATP binds and flips to the cytosol so it can be used! 

This cycle continues...

The motive force to flip the translocase is driven by the charge of ADP and ATP respectively! (via the proton gradient)

ATP is very negatively charged, and there is a lot of positive charge in the cytosol, and less in the matrix.