Embedded Files
Lab's members
Lab's members
From the first to the last committed to research on rare diseases from a basic and translational point of view.
And of course, participating in the training of new researchers as teachers at the University Pablo de Olavide.
Latest papers
Isolation of Mitochondria from Mouse Skeletal Muscle for Respirometric Assays. Journal of Visualized Experiments, 2022 180, 63336. DOI
CIBERER: Spanish National Network for Research on Rare Diseases: a highly productive collaborative initiative. Clinical Genetics, 2022 DOI
Cardiac fibroblasts display endurance to ischemia, high ROS control and elevated respiration regulated by the JAK2/STAT pathway. The FEBS Journal, 2021 febs.16283. DOI
Coenzyme Q at the Hinge of Health and Metabolic Diseases. Antioxidants, 2021, 10(11), 1785. DOI
The Genetic Landscape of Mitochondrial Diseases in Spain: A Nationwide Call. Genes 2021, 12(10), 1590. DOI
Celular Models for Primary CoQ Deficiency Pathogenesis Study. 2021; 22, 10211. DOI
Coenzyme Q homeostasis in aging: Response to non-genetic interventions. Free Radical Biology and Medicine, 164, 285-302. DOI
Regulation of coenzyme Q biosynthesis pathway in eukaryotes. Free Radical Biology & Medicine, 2021 165, 312-323. DOI
Serial co-expression analysis of host factors from SARS-CoV viruses highly converges with former high-throughput screenings and proposes key regulators. Briefings in Bioinformatics, 2021, 22(2), 1038-1052. DOI
Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet. Antioxidants, 2020, 9(5), 431. DOI
Secondary CoQ10 deficiency, bioenergetics unbalance in disease and aging. BioFactors. 2021;1-19 DOI
Primary Coenzyme Q Deficiencies: A Literature Review and Online Platform of Clinical Features to Uncover Genotype-Phenotype Correlations. Free Radical Biology and Medicine 2021, 167, 141–180. DOI
Laboratory Diagnosis of a Case with Coenzyme Q10 Deficiency. Clinical Chemistry 66, 1465–1467. DOI
Coenzyme Q10 Treatment Monitoring in Different Human Biological Samples. Antioxidants, 2020, DOI
Coenzyme Q in Aging; Lopez-Lluch, G., Ed.; Springer Nature Switzerland: Cham, 2020; ISBN 978-3-030-45641-2.
Design of High-Throughput Screening of Natural Extracts to Identify Molecules Bypassing Primary Coenzyme Q Deficiency in Saccharomyces cerevisiae. SLAS Discov. Adv. life Sci. R D 2020, 25, 299–309. DOI
ADCK2 Haploinsufficiency Reduces Mitochondrial Lipid Oxidation and Causes Myopathy Associated with CoQ Deficiency. J. Clin. Med. 2019, 8, 1374. DOI
Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging. Aging. 2019, 11, 7746–7779. DOI
Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals. Nutrients 2020, 12, 784. DOI
Zinc at the crossroads of exercise and proteostasis. Redox Biol. 2020, 101529. DOI
Coenzyme Q10 supplementation in aging. In Aging; Elsevier, 2020; pp. 183–192. DOI
Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet. Antioxidants 2020, 9, 431. DOI
News
Vamos a iniciar en mayo un proyecto de investigación para la búsqueda de fármacos de reposicionamiento para el tratamiento de BPAN. Para este proyecto disponemos de un contrato de un año para un investigador predoctoral (6+6 meses). El contrato es a tiempo completo y se iniciará en septiembre. Es muy valorado que el candidato esté en posición de solicitar un contrato FPU en la siguiente convocatoria. Si estás interesado, contacta con nosotros mediante este correo electrónico CelBioUPO@gmail.com, enviando tu CV. Tienes 15 días. Información de la convocatoria, aquí https://t.co/xYflff5d0n
La idea es continuarlo con una tesis doctoral
Our group is the coordinator of the Grupo de Trabajo about the use of organoids as models of rare diseases.
Our will be at the XV Reunión Anual of CIBERER 26-27 May 2022 in Casteldefells (Barcelona)
Our Projects
Cribado de reposicionamiento de fármacos para la terapia de BPAN. ENACH Asociación 2022-2023.
Advanced diagnostic tools for CoQ deficiency syndrome. R+D+i projects for universities and public research entities, Andalusian Government (P18-RT-4572) 2020-2022
Diagnóstico molecular de los defectos de la fosforilación oxidativa mitocondrial: patogénesis de las deficiencias de CoQ10 Instituto de Salud Carlos III FIS 2021-2023
Validación funcional de variantes patológicas de pacientes con deficiencia de coenzima Q10 mediante reprogramación celular. PROYECTOS I+D+i FEDER ANDALUCÍA 2014-2020
Estudio de la influencia de la actividad física en la salud y la capacidad cognitiva durante el envejecimiento. PROYECTOS I+D+i FEDER ANDALUCÍA 2014-2020
Papel de la síntesis de Coenzima Q en el mantenimiento del ADN mitocondrial PROYECTOS I+D+i FEDER ANDALUCÍA 2014-2020
Google Sites
Report abuse