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Results: Cross-sectionally, all SM and adipose tissue single-slice areas correlated with total tissue volumes (P < 0.01). Because of the close associations between L3 areas and corresponding tissue volumes (r = 0.832-0.986, P < 0.01), this location was identified as the reference to estimate SM and adipose tissue in both sexes. SM, SAT, and VAT areas at L3 explained most of the variance of total tissue volumes (69-97%, with SEs of estimation of 1.96 and 2.03 L for SM, 0.23 and 0.61 L for VAT, and 4.44 and 2.47 L for SAT for men and women, respectively. There was no major effect on the explained variance compared with that for optimal slices. For SM, the optimal slice area was shown at midthigh. With weight-loss changes in total SM, VAT, and SAT, volumes were significantly different from those at baseline (SM changes: -2.8 2.9 L; VAT changes: -0.7 1.0 L; SAT changes: -5.1 6.0 L). The area at L3 reflected changes in total VAT and SAT. To assess changes in total SM volumes, areas at midthigh showed the best evidence.

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Conclusion: In both sexes, a single MRI scan at the level of L3 is the best compromise site to assess total tissue volumes of SM, VAT, and SAT. By contrast, L3 does not predict changes in tissue components. This trial was registered at clinicaltrials.gov as NCT01737034.

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Yes, sometimes prescription glasses don't end up being perfect and may end up bothering your eyes. I once had a certain online store screw up the prescription in the left lens while the right one was correct. In many cases, you can return the glasses if you're not satisfied, but make sure to read the fine print on the store's return policy. Often, the store will remake the glasses for you or give you a full refund. However, certain sites only offer partial refunds.

Most sites offer 15-20% off your first purchase if you provide an email address. Many sites also offer additional deals with certain codes at checkout, whether it's discounts on frames, lenses, lens upgrades and sometimes you'll see a buy-one-get-one-free deal. However, typically restrictions apply, which can mean you can only use the code for certain frames and less complicated prescriptions (single lens as opposed to progressive lenses). Look for sales and new codes to crop up around various holidays.

For pure clarity, a glass or mineral glass lens is the best. But most people prefer polycarbonate lenses, which are lighter and more durable. High-index lenses are good for those who have strong prescriptions that would normally require thicker lenses. These high-tech plastic lenses end up being the same thinness as standard plastic or polycarbonate lenses that have a lighter prescription. However, you do have to pay more for high-index lenses. Arguably the best lenses are Trivex lenses, which are lightweight and durable and offer slightly better clarity than polycarbonate lenses. But they are more expensive than plastic (CR-39) and polycarbonate lenses.

Several CNET editors have bought their glasses on Warby Parker, which has a good selection of sharp-looking eyeglass frames. While glasses start at only $95 with a single-vision prescription, chances are you're going to pay a bit more -- around $150 to $200 -- based on the type of frame options you choose, your prescription and type of eyeglass lenses. Prescription sunglasses start at $195, and progressive lenses in both eyeglasses and sunglasses start at $295. But based on my and my fellow co-workers' experience, the finished products tend to be a step up from what more budget-oriented sites offer.

Notable site features: The company's mobile apps allow you to search the site by frame size and to try on various frames virtually (it works surprisingly well) and better yet, you can try up to five frames at home for five days for free. Once your five days are up, you place your box in the mail with the prepaid return label (hopefully, you find at least one style that you like from among the five you picked for the home trial). There's also a $15 online virtual vision test to renew prescriptions that are outdated. (Based on the test, you may not be eligible, however.) 

Zenni has been around for awhile, and it's the first site I used to buy cheap prescription glasses and sunglasses online. It's more of a budget-minded site, and over the years, I got some nice deals on cheap glasses, particularly when Zenni was running its occasional three-for-two glasses sales. I've had both standard eyeglasses and prescription sunglasses made here and so has fellow editor David Katzmaier, who has since graduated to Warby Parker (he said, however, he would still buy prescription sunglasses at Zenni because they're cheap and decent enough).

Notable site features: There's a Frame Fit "mirror" feature that allows you to upload a photo and see the frames on your face, as well as new "virtual" try-on feature (powered by Ditto) that allows you to see the glasses on your face as you move around using your computer's webcam or your phone's camera. This is similar to the virtual try-on feature that Warby Parker offers.

Notable site features: There's a Frame Fit "mirror" feature that allows you to upload a photo and see the frames on your face, as well as new "virtual" try-on feature (powered by Ditto) that allows you to see the glasses on your face as you move around using your computer's webcam or your phone's camera. This is similar to the virtual try-on feature that Warby Parker offers.

Founded in 2008, GlassesUSA.com offers more affordable options for buying prescription eyeglasses and designer eyeglasses online than sites like Warby Parker and Roka, with full prescription glasses starting at $19. But it also features premium designer frames from high quality eyeglasses brands, including Ray-Ban and Persol. The designer eyewear lists for more -- frames start at $89 for basic completed Rx glasses -- but discounts can bring them down in price. 

Notable site features: A virtual "mirror" feature lets you upload your photo to the site and see what a pair of eyeglasses looks like on your face shape to help you find the perfect pair of optical frames. And the company is upping the try-at-home ante. Instead of just sending you the frames, GlassesUSA will send you the frame with your actual prescription in it so you can truly try it out for up to 14 days -- though the feature is limited to certain frames and lens options. The site also offers a 100% money-back guarantee so you can return your eye glasses if you don't like what you ultimately get. Lastly, you can download a free prescription scanner app for iOS or Android that allows you to "extract the optical parameters from your current glasses" using your phone and a PC (it works with relatively simple prescriptions, so read the fine print to see its limitations). While we've spotted a few negative online reviews for GlassesUSA, the company seems to diligently follow up and respond to each one.