工學院英文書報討論

主題 TOPIC

▸　Point-of-Use (PoU) Diagnostics using Magnetic and Bioelectronic Approaches

摘要 Abstract

❝　Facing unprecedented population-ageing, the growing impact of noncommunicable diseases (NCDs) necessitates evolution in the contemporary healthcare system that was designed many decades ago. One of the key enablers is to transition diagnostics from centralized laboratories closer to patients in point-of-use (PoU) settings, which provide high effectiveness, low cost, easy access, and fast turnaround. Optical-based instrumentation is still the workhorse in clinical diagnostics, while it hardly translates to a PoU device due to requirement of complex optics, lasers, and photodetectors. 

❝　To better address NCD management, a magnetic biosensor provides PoU-friendly settings like matrix-insensitivity, rapid turnaround time, and miniaturization without a loss of sensitivity. In this talk, magneto-biosensing techniques are presented with both cellular and molecular assays. A magnetic flow cytometer (MFC) using a giant magnetoresistive (GMR) biosensor and matched filtering is developed to perform aptamer-based cancer cell detection, exhibiting an affordable signal-to-noise ratio (SNR) down to 2.5 dB. In terms of the molecular assay, magnetorelaxometry (MRX) is implemented with GMR sensors and bioelectronics, demonstrating the first realization of GMR-based time-domain MRX bioassays.　❞

講者 SPEAKER

▸　黃至正教授 Prof. Chih-Cheng HUANG / 國立清華大學生命科學暨醫學院精準醫療博士學位學程 Precision Medicine Ph.D. Program, College of Life Sciences and Medicine, National Tsing Hua University

時間 TIME

▸　2024/04/30 (TUE) 13:20 ~ 15:10

地點 VENUE

▸　化工館202教室 Classroom 202, Chemical Engineering Building

主題 TOPIC

▸　Harnessing 3D Cell Spheroids and Their Derived ECM for Regenerative Medicine

摘要 Abstract

❝　Cell transplantation has shown promise as a therapy for various diseases and injuries. Traditionally, cells are harvested as single-cell suspensions and transplanted into the affected area. However, this method faces challenges such as significant cell loss due to mechanical leakage, cell detachment-associated anoikis, and adverse microenvironments in the target tissues, which limit their therapeutic efficacy. To overcome these limitations, we propose the assembly of cells into three-dimensional (3D) spheroids to enhance cell retention, survival, and regenerative capacity. Our results of in vitro and in vivo studies reveal that mesenchymal stem cells (MSCs) transplanted as 3D spheroids, incorporating both cellular components and the extracellular matrix (ECM), yield superior therapeutic outcomes compared to traditional single-cell suspensions. Furthermore, we have developed a novel approach using decellularized ECM (dECM) derived from MSC spheroids, enriched with matrisome proteins and secretome. This bioactive biomaterial has proven effective in regenerative applications, as demonstrated in a mouse model of traumatic brain injury. The implantation of this 3D dECM significantly mitigated tissue damage and promoted brain repair, evident from the reduced lesion volume, alleviated neuroinflammation, decreased glial scar formation, and enhanced recruitment of neuroblasts to the injury site. In conclusion, our research highlights the potential of MSC spheroids and their derived bioactive 3D dECM as potent therapeutic agents for regenerative medicine applications.　❞

講者 SPEAKER

▸　黃玠誠教授 Prof. Chieh-Cheng Huang / 國立清華大學生物醫學工程研究所 Institute of Biomedical Engineering, National Tsing Hua University

時間 TIME

▸　2024/04/30 (TUE) 13:20 ~ 15:10

地點 VENUE

▸　化工館202教室 Classroom 202, Chemical Engineering Building

主題 TOPIC

▸　Fuzzy MCDM, COA and Fuzzy VIKOR

摘要 Abstract

❝　The terms MCDM (or MCDA, "A" for analysis) and MADM sometimes are used interchangeably in the literature. Multi-attribute decision making (MADM) methods are designed for problems with a pre-defined discrete set of alternatives, whereas multi-objective decision making (MODM) methods are for problems where alternatives are not pre-defined. In fuzzy MCDM, the ratings of alternatives versus criteria and the importance weights for criteria are usually assessed by linguistic terms represented by fuzzy numbers. After aggregating fuzzy ratings and weightings, a fuzzy number ranking method is needed to defuzzify final fuzzy weighted ratings for decision making. In this talk, some basic concepts in fuzzy set theory, such as fuzzy number, alpha-cuts, arithmetic operations of fuzzy numbers etc. will be introduced. The ranking method, center of area (COA), applied in triangular and trapezoidal fuzzy numbers will be presented, some properties will be discussed with proofs provided. Finally, fuzzy VIKOR, one of the commonly used fuzzy MCDM, will be introduced. The name of VIKOR in Serbian is "VIseKriterijumska Optimizacija I Kompromisno Resenje", which means "Multicriteria Optimization and Compromise Solution" in English. An extension to fuzzy VIKOR will be presented and numerical example will be provided to demonstrate the feasibility of the proposed method.　❞

講者 SPEAKER

▸　朱大中教授 Prof. Ta- Chung CHU / 南臺科技大學工業管理與資訊學系 Department of Industrial Management and Information, Southern Taiwan University of Science and Technology

主持 HOST

▸　葉維彰教授 Prof. Wei-Chang Yeh / 國立清華大學工業工程與工程管理學系 Department of Industrial Engineering and Engineering Management, National Tsing Hua University

時間 TIME

▸　2024/04/23 (TUE) 13:20 ~ 15:10

地點 VENUE

▸　化工館202教室 Classroom 202, Chemical Engineering Building