Publications

  1. Balachandran, N., Grainger, R. A., Rob, T., Liuni, P., Wilson, D. J., Junop, M. S., & Berti, P. J. (2022) Biochemistry 61: 2229-2240 Role of Half-of-Sites Reactivity and Inter-Subunit Communications in DAHP Synthase Catalysis and Regulation (link)

  2. Heimhalt, M., Mukherjee, P., Grainger, R. A., Szabla, R., Brown, C., Turner, R., Junop, M. S., & Berti, P. J. (2021) ACS Infect. Dis. 7: 3292-3302 An Inhibitor-in-Pieces Approach to DAHP Synthase Inhibition: Potent Enzyme and Bacterial Growth Inhibition (link)

  3. Popovic, V., Morrison, E., Rosanally, A. Z., Balachandran, N., Senson, A. W., Szabla, R., Junop, M. S., & Berti, P. J. (2019) Biochemistry 58: 4236-4245 NeuNAc oxime: A slow-binding and effectively irreversible inhibitor of the sialic acid synthase NeuB (link)

  4. Heimhalt, M., Jiang, S., & Berti, P. J. (2018) Biochemistry 57: 6679-6687 Eliminating competition: Characterizing and eliminating competitive binding at separate sites between DAHP synthase's essential metal ion and the inhibitor DAHP oxime (link)

  5. Gama, S. R., Balachandran, N., & Berti, P. J. (2018) Biochemistry 57: 5327-5338 Campylobacter jejuni KDO8P Synthase Its Inhibition by KDO8P Oxime, and Control of the Residence Time of Slow-Binding Inhibition (link)

  6. Ioppolo, J. A., Caldwell, D., Beiraghi, O., Llano, L., Blacker, M., Valliant, J. F. & Berti, P. J. (2017) Nucl. Med. Biol. 52: 32-41 67Ga-labelled deferoxamine derivatives for imaging bacterial infection: Preparation and screening of functionalized siderophore complexes (link)

  7. Balachandran, N., To, F., & Berti, P. J. (2017) Biochemistry 56: 592-601 Linear Free Energy Relationship Analysis of Transition State Mimicry by 3-Deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) Oxime, a DAHP Synthase Inhibitor and Phosphate Mimic (link)

  8. Balachandran, N., Heimhalt, M., To, F., Liuni, P., Wilson, D. J., Junop, M. S. & Berti, P. J. (2016) Biochemistry 55: 6617-6629 Potent Inhibition of 3-Deoxy-D-arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic (link)

  9. Vito, A., Alarabi, H., Czorny, S., Beiraghi, O., Kent, J., Janzen, N., Genady, A. R., Ali-Karmi, S. A., Rathmann, S., Naperstkow, Z., Blacker, M., Llano, L., Berti, P. J. & Valliant, J. F. (2016) PLoS One 11: e0167425 A 99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives (link)

  10. Lou, M., Gilpin, M. E., Burger, S. K., Malik, A. M., Gawuga, V., Popovic, V., Capretta, A. & Berti, P. J. (2012) J. Am. Chem. Soc. 134: 12947-12957 Transition State Analysis of Acid-Catalyzed Hydrolysis of an Enol Ether, Enolpyruvylshikimate 3-Phosphate (EPSP) (link)

  11. Lou, M., Burger, S. K., Gilpin, M. E., Gawuga, V., Capretta, A. & Berti, P. J. (2012) J. Am. Chem. Soc. 134: 12958-12969 Transition State Analysis of Enolpyruvylshikimate 3-Phosphate Synthase (AroA)-Catalyzed EPSP Hydrolysis (link)

  12. Rob, T., Liuni, P., Gill, P. K., Zhu, S., Balachandran, N., Berti, P. J. & Wilson, D. J. (2012) Anal. Chem. 84: 3771-3779 Measuring dynamics in weakly structured regions of proteins using microfluidics-enabled subsecond H/D exchange mass spectrometry (link)

  13. Jiang, S., Gilpin, M. E., Attia, M., Ting, Y.-L. & Berti, P. J. (2011) Biochemistry 50: 2205-2212 Lyme Disease Enolpyruvyl-UDP-GlcNAc Synthase: Fosfomycin-Resistant MurA from Borrelia burgdorferi, a Fosfomycin-Sensitive Mutant, and the Catalytic Role of the Active Site Asp (link)

  14. Jackson, S. G., Zhang, F., Chindemi, P., Junop, M. S. & Berti, P. J. (2009) Biochemistry 48: 11715-11723 Evidence for Kinetic Control of Ligand Binding and Staged Product Release in MurA (Enolpyruvyl UDP-GlcNAc Synthase)-Catalyzed Reactions (link)

  15. Berti, P. J. & Chindemi, P. (2009) Biochemistry 48: 3699-3707 Catalytic Residues and an Electrostatic Sandwich That Promote Enolpyruvyl Shikimate 3-Phosphate Synthase (AroA) Catalysis (link)

  16. McCann, J. A. B. & Berti, P. J. (2008) J. Am. Chem. Soc. 130: 5789-5797 Transition State Analysis of the DNA Repair Enzyme MutY (link) (movie)

  17. McCann, J. A. B. & Berti, P. J. (2007) J. Am. Chem. Soc. 129: 7055-7064 Transition State Analysis of Acid-catalyzed dAMP Hydrolysis (link)

  18. Clark, M. E. & Berti, P. J. (2007) Biochemistry 46: 1933-1940 Enolpyruvyl Activation by Enolpyruvyl Shikimate 3-Phosphate Synthase (link)

  19. Zhang, F. & Berti, P. J. (2006) Biochemistry 45: 6027-6037 Phosphate Analogues as Probes of the Catalytic Mechanisms of MurA and AroA, Two Carboxyvinyl Transferases (link)

  20. Loncke, P. G. & Berti, P. J. (2006) J. Am. Chem. Soc. 128: 6132-6140 Implications of Protonation and Substituent Effects for C-O and O-P Bond Cleavage in Phosphate Monoesters (link)

  21. Berti, P. J. & McCann, J. A. B. (2006) Chem. Rev. 106: 506-555 Toward a Detailed Understanding of Base Excision Repair Enzymes: Transition State and Mechanistic Analyses of N-Glycoside Hydrolysis and N-Glycoside Transfer (link)

  22. Mizyed, S., Oddone, A., Byczynski, B., Hughes, D. W., & Berti, P. J. (2005) Biochemistry 44: 4011-4017 UDP-N-acetylmuramic acid (UDP-MurNAc) is a Potent Inhibitor of MurA (Enolpyruvyl-UDP-GlcNAc Synthase) (link)

  23. Lee, J. K., Bain, A. D. & Berti, P. J. (2004) J. Am. Chem. Soc. 126: 3769-3776 Probing the Transition States of Four Glucoside Hydrolyses with 13C Kinetic Isotope Effects Measured at Natural Abundance by NMR Spectroscopy. (link)

  24. Byczynski, B., Mizyed, S. & Berti, P. J. (2003) J. Am. Chem. Soc. 125: 12541-12550 Non-enzymatic Breakdown of the Tetrahedral (α-Carboxyketal Phosphate) Intermediates of MurA and AroA, Two Carboxyvinyl Transferases. Protonation of Different Functional Groups Control the Rate and Fate of Breakdown. (link)

  25. McCann, J. A. B. & Berti, P. J. (2003) J. Biol. Chem. 278: 29587-29592 Adenine Release is Fast in MutY-Catalyzed Hydrolysis of G:A and 8-oxo-G:A DNA Mismatches (link)

  26. Mizyed, S., Wright, J. E. I., Byczynski, B. & Berti, P. J. (2003) Biochemistry 42: 6986-6995 Identification of the Catalytic Residues of AroA (Enolpyruvylshikimate 3-Phosphate Synthase) Using Partitioning Analysis (link)

  27. Berti, P. J., & Tanaka, K. S. E. (2002) Adv. Phys. Org. Chem. 37: 239-314 Transition State Analysis Using Multiple Kinetic Isotope Effects: Mechanisms of Enzymatic and Non-enzymatic Glycoside Hydrolysis and Transfer (link)

  28. Chen, X.-Y., Berti, P. J. & Schramm, V. L. (2000) J. Am. Chem. Soc. 122: 6527-6534 Transition State Analysis for Depurination of DNA by Ricin A-Chain

  29. Chen, X.-Y., Berti, P. J. & Schramm, V. L. (2000) J. Am. Chem. Soc. 122: 1609-1617 Ricin A-Chain: Kinetic Isotope Effects and Transition State Structure with Stem-Loop RNA

  30. Berti, P. J. (1999) Methods Enzymol. 308: 355-397 Determining Transition States from Kinetic Isotope Effects

  31. Berti, P. J. & Schramm, V. L. (1999) Enzymatic Transition State Structures Constrained by Experimental Kinetic Isotope Effects in ACS Symposium Series No. 721/Transition State Modeling for Catalysis ; Trulhar, D. G., Morokuma, K., Eds.; American Chemical Society: Washington, D.C.; pp 473-488

  32. Scheuring, J., Berti, P. J. & Schramm, V. L. (1998) Biochemistry 37: 2748-2758 Pertussis Toxin: Transition State Structure for ADP-ribosylation of Recombinant Giα1 Subunits

  33. Berti, P. J., Blanke, S. R. & Schramm, V. L., (1997) J. Am. Chem. Soc. 119: 12079-12088 Transition State Structure for the Hydrolysis of NAD+ Catalyzed by Diphtheria Toxin

  34. Berti, P. J. & Schramm, V. L. (1997) J. Am. Chem. Soc. 119: 12069-12078 Transition State Structure of the Solvolytic Hydrolysis of NAD+


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