# BeriCos® PAD (Potassium Azeloyl Diglycinate): CAS No.: 477773-67-4  Guidelines for Cosmetic Formulation & Practical Applications

## Overview

BeriCos® PAD (Potassium Azeloyl Diglycinate) is an innovative, water-soluble azelaic acid derivative independently developed and manufactured. Conventional azelaic acid suffers from poor water solubility, limited pH adaptability, irritating potential and inherent odour challenges, which greatly restrict formulation flexibility. By glycine modification, BeriCos® PAD (Potassium Azeloyl Diglycinate) overcomes these technical bottlenecks. Featuring high purity, excellent stability, fully odorless property and multi-functional skincare efficacy, this active ingredient is highly formulator-friendly and suitable for a wide spectrum of aqueous cosmetic systems.

This article focuses on practical formulation guidance, key compatibility notes, processing recommendations and typical finished product applications for BeriCos® PAD (Potassium Azeloyl Diglycinate).

## 1. Core Formulation Properties of BeriCos® PAD (Potassium Azeloyl Diglycinate)

### 1.1 Solubility

BeriCos® PAD (Potassium Azeloyl Diglycinate) is **100% water-soluble**. No ethanol, glycols or other solubilizers are required to dissolve the raw material. It can be directly added to the aqueous phase under gentle stirring. It does not form precipitates or cloudiness in transparent formulas, making it ideal for clear serums, essences and toners.

### 1.2 Suitable pH Range

Optimal formulation pH: **4.0 – 8.5**.

It maintains stable activity within this broad pH window, compatible with most daily skincare formulations. Avoid long-term storage under pH below 3.0 to prevent molecular hydrolysis.

### 1.3 Thermal Stability

BeriCos® PAD (Potassium Azeloyl Diglycinate) tolerates standard cosmetic heating processes (≤85°C). It supports both hot-mix and cold-mix production techniques. No significant activity loss or discoloration occurs after heating and cooling cycles.

### 1.4 Odor Advantage

Distinct from many azelaic acid derivatives on the market, BeriCos® PAD (Potassium Azeloyl Diglycinate) is completely odorless. Formulators do not need to add extra fragrances or deodorants to mask unpleasant chemical odors. It perfectly fits fragrance-free, sensitive-skin and clean beauty concepts.

### 1.5 Appearance

High-purity raw material presents as white powder; when dissolved in water, it forms a clear, colourless aqueous solution, and will not cause yellowing or turbidity of finished products during shelf life.

## 2. Recommended Dosage

**Typical usage concentration: 1% – 5%**

- Mild maintenance skincare (daily balancing toner, moisturizer): 1% – 2%

- Targeted blemish control, brightening serum, spot essence: 2% – 5%

> Note: Formulators are recommended to conduct gradient efficacy tests and stability tests according to positioning of finished products. Higher dosage does not equal better effect; balance formula irritation risk and user experience.

## 3. Ingredient Compatibility Guide

### Compatible Raw Materials

BeriCos® PAD (Potassium Azeloyl Diglycinate) shows excellent compatibility with mainstream cosmetic ingredients:

- Moisturizers: Hyaluronic acid, panthenol, glycerin, betaine

- Common actives: Niacinamide, Alpha-Arbutin, Centella Asiatica extract, Polyglutamic acid

- Preservative systems: Common cosmetic preservatives within the suitable pH range (phenoxyethanol, caprylyl glycol, etc.)

- Emulsifiers: Non-ionic and mild anionic emulsifiers for lotions and creams

### Ingredients Requiring Pre-test

- Strong acid systems: High concentration AHAs/BHAs at pH <3.5, need accelerated stability testing

- High-concentration cationic polymers: May trigger incompatibility, pre-formulation verification is required

- Strong oxidizing raw materials: Avoid direct long-term mixing

## 4. Production Operation Suggestions

1. **Feeding sequence**

Add BeriCos® PAD (Potassium Azeloyl Diglycinate) into the aqueous phase at 25–60°C under continuous stirring until fully dissolved. 

Do not dump large amount of powder at once to avoid agglomeration.

2. **Emulsion system operation**

Add during aqueous phase preparation before emulsification; alternatively add in the cooling stage after emulsification.

3. **Storage reminder for raw material**

Seal and store in dry, cool environment; avoid prolonged exposure to high humidity.

## 5. Typical Cosmetic Application Formulations

### 5.1 Brightening & Post-Acne Marks Serum

- Positioning: Fade inflammatory pigmentation, improve dull complexion

- Recommended dosage: 2%–4%

- Formula type: Transparent aqueous serum

- Matching suggestion: Combine with panthenol and centella extract to strengthen soothing effect.

### 5.2 Oil-Control & Anti-Blemish Balancing Toner

- Positioning: Regulate sebum, reduce periodic breakouts, refine pores

- Recommended dosage: 1%–2.5%

- Advantage: Clear formula, odorless, refreshing texture for oily and combination skin.

### 5.3 Soothing Moisturizer for Sensitive & Redness-Prone Skin

- Positioning: Anti-inflammatory, relieve flushing, gentle daily care

- Recommended dosage: 1%–3%

- Advantage: Better skin tolerance than free azelaic acid, suitable for sensitive skin prone to acne and redness.

### 5.4 Facial Cleanser (Wash-off system)

- Positioning: Mild oil control, prevent pore clogging

- Recommended dosage: 1%–2%

- Tip: Select mild amphoteric/anionic surfactant systems; avoid extreme pH formulas.

### 5.5 Post-Procedure Repair Care

- Positioning: Reduce inflammation, inhibit pigmentation after skin treatment

- Recommended dosage: 1.5%–3%

- Feature: Low irritation, odorless, compatible with mild repair systems.

## 6. Formulation Risk Reminders

1. Conduct accelerated stability testing (45°C, freeze-thaw cycle) for each finished formula to verify colour, transparency and activity retention.

2. For products targeting sensitive skin, complete human patch tests before mass production.

3. Although BeriCos® PAD is non-photosensitizing, it is still recommended to add UV protection for daytime brightening products for optimal consumer effect.

## 7. Summary

As an independently developed high-purity active, BeriCos® PAD (Potassium Azeloyl Diglycinate) solves multiple formulation pain points of traditional azelaic acid: poor solubility, unpleasant odour, narrow pH tolerance and irritation risks.

With outstanding water solubility, wide pH adaptability, thermal stability and odorless property, it brings tremendous flexibility for formulators to develop transparent serums, toners, emulsions and cleansing products targeting oil control, anti-acne, soothing and brightening. Supported by stable in-house supply and complete technical documentation, BeriCos® PAD (Potassium Azeloyl Diglycinate) is a reliable multifunctional active choice for modern clean beauty and sensitive skincare.

Elena@zhberi.com  +8619500796925

Potassium Azeloyl Diglycinate Manufacturer - Beri Pharma