Ben Seiyon Lee

Assistant Professor, Department of Statistics

George Mason University

About Me

I am an Assistant Professor in the Department of Statistics at George Mason University. I received my Ph.D. in Statistics from the Pennsylvania State University where I was advised by Dr. Murali Haran (Statistics) and co-advised by Dr. Klaus Keller (Geosciences). During my graduate studies, I was a part of the research network for Sustainable Climate Risk Management (SCRiM) and the Program on Coupled Human and Earth Systems (PCHES).

My research interests include:

computational methods for high-dimensional hierarchical spatial / spatio-temporal models
statistical methods and parallelized algorithms for computer model calibration
uncertainty quantification
Bayesian hierarchical modeling
interdisciplinary research in the environmental sciences
bioengineering applications
biostatistics and translational research in collaboration with INOVA Health System

News and Updates (since February 2024)

12/25: Congratulations to Isaac Amouzou for successfully defending his MS thesis on 4/24. We wish him all the best as he begins the next chapter of his academic journey at Texas A&M University.
From January 20 through May 21, 2026, I will be a visiting scholar in the Department of Biostatistics at the Johns Hopkins Bloomberg School of Public Health, collaborating with Dr. Abhi Datta.
12/25: Congratulations to Jolypich Pek for passing her proposal defense.
10/25: Congratulations to Dr. Jin Hyung Lee for successfully defending on October 21st! We wish him the best at his next stop as a postdoctoral associate in the department of statistics at Purdue University.
10/25: Our manuscript "A Dimension-Reduced Multivariate Spatial Model for Extreme Events: Balancing Flexibility and Scalability" has been accepted at the Journal of Agricultural, Biological, and Environmental Statistics. This work was funded by the NOAA SBIR grant with Dr. John Foley (Metron) and Justin Lee (Metron).
09/25: I am excited to be part of a $4.65M NIH-funded study led by Dr. Siddhartha Sikdar at George Mason University to advance understanding and treatment of chronic knee pain.
08/25: Congratulations to Jin Hyung Lee for receiving the Oustanding Student Paper Award from the Korean International Statistical Society (KISS) at JSM!
07/25: Our manuscript "A Scalable Variational Bayes Approach to Fit High-dimensional Spatial Generalized Linear Mixed Models" has been accepted at Technometrics.
01/25: Congratulations to Yu-lin Hsu for passing her proposal defense.
07/24: Congratulations to Dr. Remy MacDonald for a successful thesis defense on July 25th! Next stop, the FDA as a mathematical statistician.
07/24: Our book chapter Latent Gaussian Models and Computation for Large Spatial Data will appear in the Handbook of MCMC.
06/24: I gave a talk at the SRCOS Annual Summer Research Conference on "A Class of Models for Large Zero-inflated Spatial Data".
05/24: Our manuscript "Flexible Basis Representations for Modeling Large Non-Gaussian Spatial Data" has been accepted at Spatial Statistics.
05/24: Our manuscript "Guideline-Directed Medical Therapy Implementation During Hospitalization for Cardiogenic Shock" has been accepted at ESC: Heart Failure.
05/24: Excited to start our collaboration with Lawrence Livermore National Labs through the Academic Collaboration Team (ACT) Program with Dr. Jason Bernstein and Dr. Philip Myint. The collaboration supports Ph.D student Jolypich Pek .
04/24: I received a Faculty Excellence Award from the College of Engineering and Computing (CEC) - 2024 Outstanding Tenure-Track Faculty.
04/24: Our manuscript "A Class of Models for Large Zero-inflated Spatial Data" has been published at the Journal of Agricultural, Biological, and Environmental Statistics.
03/24: Looking forward to working with Drs. Samuel Acuna (BENG), Kevin Lybarger (IST), and Siddhartha Sikdar (BENG) on our recently awarded Summer Team Impact Project Grant, "Recording the lived experiences of patients with chronic pain from minoritized and underserved communities." The grant will support multidisciplinary summer projects of undergraduate students, graduate students, and faculty members for Summer 2024, and we will welcome six undergraduate researchers to our group, including Statistics accelerated bachelors-to-masters student Isaac Paki Amouzou.
02/24: Congratulations to Ph.D student Jin Hyung Lee for successfully defending his thesis proposal.
02/24: We successfully completed Phase I of a NOAA-Small Business Innovation Research Program grant titled "EXCLAIM: A Decision Support Toolkit to Mitigate Impacts of Cascading Climate Hazards)" with Dr. John Foley from Metron, Inc.

Education

The Pennsylvania State University, Ph.D. Statistics, 2020

Columbia University, M.A., Applied Statistics (, 2015

Johns Hopkins University, B.A., International Studies, 2008

Contact

Email: slee287 [at] gmu [period] edu

Phone: (703) 993-9113

Office: Nguyen Engineering Building Room 1709

Mailing Address:
4400 University Drive, MS 4A7
Fairfax, VA 22030, USA.
College of Engineering and Computing
George Mason University

Looking to Collaborate?

Collaborators (and Coffee!): If you are interested in collaborating or just want to chat about research, feel free to reach out! We can set up a meeting to discuss in-person or via Zoom. If you want to grab coffee on campus, we could drop by the Starbucks at the Johnson Center or Northern Neck.

INOVA-GMU Collaborative Core: If you are an INOVA health care professional interested in collaborating with me through the GMU-INOVA Collaborative Core, please visit the collaboration homepage.

Students: I am also looking for motivated graduate students to join my research lab. If you have a background in statistical computing and/or are interested in applications in the environmental sciences, please send me an email. Our group will work on a variety of projects related to spatial and spatio-temporal statistics, uncertainty quantification and computer model calibration, Bayesian methodology development, and extreme value analysis in the climate sciences.

Curriculum Vitae

My CV can be found here . (updated 06/2025)

Publications

Journal Articles

[32] Lee, J.H. and Lee, B.S. A Scalable Variational Bayes Approach for Fitting Non-Conjugate Spatial Generalized Linear Mixed Models via Basis Expansions. Computational Statistics and Data Analysis. To appear.

[31] Sikdar, S., DeStefano, S., Guzmán Pavón, M.J., Hsu, Y.-L., Lee, B.S., Srbely, J., Shah, J., Rosenberger, W., Acuña, S., Assefa, Y., Jirsaraei, M.J., Stecco, A., and Gerber, L.H. Multidimensional Analysis of the Clinical Spectrum and Symptom Burden of Unexplained Myofascial Pain. Archives of Physical Medicine and Rehabilitation. To appear.

[30] Lamarre, M.A., Koduri, S., Akhwand, R.A., Hsu, Y.-L., Lee, B.S., Rosenberger, W.F., DeStefano, S., Srbely, J., Shah, J.P., Gerber, L.H., Acuña, S.A., and Sikdar, S. Reliability of Bioimpedance Spectroscopy in the Upper Trapezius Muscle. Journal of Electromyography and Kinesiology.

[29] Jahani Jirsaraei, M., Lee, B.S., DeStefano, S., Gerber, L.H., Ji, W., and Sikdar, S. Multidomain Analysis of Chronic Pain Intensity in Labor-Intensive Occupations: Insights from Network and Regression Modeling. Journal of Construction Engineering and Management.

[28] Rios, N. and Lee, B.S. REX-SUB: A Scalable Subsampling Strategy for Modeling Large Spatial Datasets. Computational Statistics and Data Analysis.

[27] Tehrani, B.N., Rosner, C.M., Fadahunsi, A., Barker, K., Batchelor, W.B., Blumer, V., Clevenger, L., Desai, S., Ferri, M., Franke, E., Kennedy, J., King, C., Howard, E., Isseh, I., Lee, B.S., Mehta, A., Psotka, M., Singh, R., Sinha, S.S., Sherwood, M.W., Tang, D., Terek, M., Truesdell, A.G., Vavilin, I., and O’Connor, C.M. Impact of Standardized Team-Based Care on Cardiogenic Shock Outcomes over Time. ESC Heart Failure.

[26] Lu, Y., Lee, B.S., and Doss-Gollin, J. Bayesian Spatiotemporal Nonstationary Model Quantifies Robust Increases in Daily Extreme Rainfall across the Western Gulf Coast. Environmental Research: Climate.

[25] Li, Y., Tong, D., Jeon, Y., Lee, B.S., Park, J., Kondragunta, S., and Zhang, S. Using AOD and UVAI to Reduce the Uncertainties in Wildfire Emission and Air Quality Modeling. Journal of Geophysical Research: Atmospheres.

[24] Dimond, M.G., Rosner, C.M., Lee, B.S., Shakoor, U., Samadani, T., Batchelor, W.B., Damluji, A.A., Desai, S.S., Epps, K.C., Flanagan, M.C., and Moukhachen, H. Guideline-Directed Medical Therapy Implementation during Hospitalization for Cardiogenic Shock. ESC Heart Failure.

[23] MacDonald, R., Lee, B.S., Foley, J., and Lee, J. A Dimension-Reduced Multivariate Spatial Model for Extreme Events: Balancing Flexibility and Scalability. Journal of Agricultural, Biological, and Environmental Statistics.

[22] Lee, J.H. and Lee, B.S. A Variational Approach for Modeling High-Dimensional Spatial Generalized Linear Mixed Models. Technometrics.

[21] Lee, B.S. and Haran, M. A Class of Models for Large Zero-Inflated Spatial Data. Journal of Agricultural, Biological, and Environmental Statistics.

[20] Hosseini-Shakib, I., Alipour, A., Lee, B.S., Srikrishnan, V., Nicholas, R., Keller, K., and Sharma, S. What Drives Uncertainty Surrounding Riverine Flood Risks? Journal of Hydrology.

[19] Lawrence, J.R., Lee, B.S., Fadahunsi, A.I., and Mowery, B.D. Evaluating Sepsis Bundle Compliance as a Predictor for Patient Outcomes at a Community Hospital: A Retrospective Study. Journal of Nursing Care Quality.

[18] Shah, P., Agbor-Enoh, S., Lee, B.S., Andargie, T., Sinha, S., Kong, H., Henry, L., Park, W., McNair, E., Tchoukina, I., Shah, K., Najjar, S., Hsu, S., Rodrigo, M., Jang, M.K., Marboe, C., Berry, G., and Valantine, H. Racial Differences in Donor-Derived Cell-Free DNA and Mitochondrial DNA after Heart Transplantation, on Behalf of the GRAfT Investigators. Circulation: Heart Failure.

[17] Roth, S., Lee, B.S., Nicholas, R.E., Keller, K., and Haran, M. Bayesian Spatial Models for Projecting Corn Yields. Remote Sensing.

[16] MacDonald, R. and Lee, B.S. Flexible Basis Representations for Modeling High-Dimensional Hierarchical Spatial Data. Spatial Statistics.

[15] Patwardhan, S., Gladhill, K.A., Joiner, W.M., Schofield, J.S., Lee, B.S., and Sikdar, S. Using Principles of Motor Control to Analyze the Performance of Human-Machine Interfaces. Scientific Reports.

[14] Sharma, S., Lee, B.S., Hosseini-Shakib, I., Haran, M., and Keller, K. Neglecting Model Parametric Uncertainty Can Drastically Underestimate Flood Risks. Earth’s Future.

[13] Rosner, C.M., Lee, B.S., Badrish, N., Maini, A.S., Young, K.D., Vorgang, C.M., Bagnola, A., Desai, S.S., Hahndorf, C., Looby, M., and Psotka, M.A. Advanced Practice Provider Urgent Outpatient Clinic for Patients with Decompensated Heart Failure. Journal of Cardiac Failure.

[12] Roth, S.M., Lee, B.S., Sharma, S., Hosseini-Shakib, I., Keller, K., and Haran, M. Flood Hazard Model Calibration Using Multiresolution Model Output. Environmetrics.

[11] Lee, B.S. and Park, J. A Scalable Partitioned Approach to Model Massive Nonstationary Non-Gaussian Spatial Datasets. Technometrics.

[10] Srikrishnan, V., Lafferty, D.C., Wong, T.E., Lamontagne, J.R., Quinn, J.D., Sharma, S., Molla, N.J., Herman, J.D., Sriver, R.L., Morris, J.F., and Lee, B.S. Uncertainty Analysis in Multisector Systems: Considerations for Risk Analysis, Projection, and Planning for Complex Systems. Earth’s Future.

[9] Tehrani, B.N., Sherwood, M.W., Rosner, C., Truesdell, A.G., Lee, B.S., Damluji, A.A., Desai, M., Desai, S.S., Epps, K.C., Flanagan, M.C., Howard, E., Ibrahim, N., Kennedy, J., Moukhachen, H., Psotka, M., Raja, A., Saeed, I., Shah, P., Singh, R., Sinha, S.S., Tang, D., Welch, T., Young, K., deFilippi, C.R., Speir, A., O’Connor, C.M., and Batchelor, W.B. A Standardized and Regionalized Network of Care for Cardiogenic Shock. JACC: Heart Failure.

[8] Sinha, S.S., Rosner, C.M., Tehrani, B.N., Maini, A., Truesdell, A.G., Lee, B.S., Bagchi, P., Cameron, J., Damluji, A.A., Desai, M., Desai, S.S., Epps, K.C., deFilippi, C., Flanagan, M.C., Genovese, L., Moukhachen, H., Park, J.J., Psotka, M.A., Raja, A., Shah, P., Sherwood, M.W., Singh, R., Tang, D., Young, K.D., Welch, T., O’Connor, C.M., and Batchelor, W.B. Cardiogenic Shock from Heart Failure versus Acute Myocardial Infarction: Clinical Characteristics, Hospital Course, and One-Year Outcomes. Circulation: Heart Failure.

[7] Doshi, A., Shah, K.B., Agbor-Enoh, S., Tushak, Z., Garcia, V., Kong, H., Jang, M.K., Hsu, S., Feller, E.D., Rodrigo, M.E., Najjar, S.S., Tunc, I., Yang, Y., Lee, B.S., Solomon, M.A., Berry, G., Marboe, C., Shah, P., and Valantine, H.A. Higher Levels of Allograft Injury in Black Patients Early after Heart Transplantation. The Journal of Heart and Lung Transplantation.

[6] Sharma, S., Ghimire, G.R., Talchabhadel, R., Panthi, J., Lee, B.S., Sun, F., Baniya, R., and Adhikari, T.R. Bayesian Characterization of Uncertainties Surrounding Fluvial Flood Hazard Estimates. Hydrological Sciences Journal.

[5] Lee, B.S. and Haran, M. PICAR: An Efficient Extendable Approach for Fitting Hierarchical Spatial Models. Technometrics.

[4] Sharma, S., Lee, B.S., Nicholas, R.E., and Keller, K. A Safety Factor Approach to Designing Urban Infrastructure for Dynamic Conditions. Earth’s Future.

[3] Lee, B.S., Haran, M., Fuller, R.W., Pollard, D., and Keller, K. A Fast Particle-Based Approach for Calibrating a 3-D Model of the Antarctic Ice Sheet. The Annals of Applied Statistics.

[2] Oddo, P.C., Lee, B.S., Garner, G.G., Srikrishnan, V., Reed, P.M., Forest, C.E., and Keller, K. Deep Uncertainties in Sea-Level Rise and Storm Surge Projections: Implications for Coastal Flood Risk Management. Risk Analysis.

[1] Lee, B.S., Haran, M., and Keller, K. Multidecadal Scale Detection Time for Potentially Increasing Atlantic Storm Surges in a Warming Climate. Geophysical Research Letters.

Books and Book Chapters

[B2] Haran, M., Hughes, J.P., and Lee, B.S. Latent Gaussian Models and Computation for Large Spatial Data. In Craiu, R.V., Vats, D., Jones, G.L., Brooks, S., Gelman, A., and Meng, X.-L., editors, Handbook of Markov Chain Monte Carlo, Second Edition. CRC Press.

[B1] Reed, P.M., Hadjimichael, A., Malek, K., Karimi, T., Vernon, C.R., Srikrishnan, V., Gupta, R.S., Gold, D.F., Lee, B.S., Keller, K., Thurber, T.B., and Rice, J.S. Addressing Uncertainty in Multisector Dynamics Research. Zenodo.

Manuscripts Under Review

[S6] Lee, B.S., Hsu, Y.-L., Rosenberger, W.F., and Sikdar, S. Unique Design and Analysis Features of a Clinical Study for Multimodal Biomarker Development. Under review.

[S5] Assefa, Y., Gerber, L.H., Hsu, Y.-L., Srbely, J., DeStefano, S., Shah, J., Lee, B.S., Amouzou, I., Rosenberger, W., Acuña, S., Jirsaraei, M.J., Stecco, A., and Sikdar, S. Patient Self-Reports of Pain Laterality in Patients with Chronic Myofascial Pain Is Associated with a High Burden of Symptoms Using Multidimensional Clinical Assessments. Submitted.

[S4] Lee, B.S., Majumder, R., Richards, J., Simpson, E.S., and Zhang, L. Spatial Extremes at Scale: A Case Study of Surface Skin Temperature and Heat Risk in the United States. Under review.

[S3] Amouzou, I. and Lee, B.S. A Cubing Strategy for Identifying Stable Hyperparameter Regions for Uncertainty Quantification in Spatial Deep Learning. Under review.

[S2] Jirsaraei, M.J., Hsu, Y.-L., Akhwand, R., Aher, A., Lee, B.S., DeStefano, S., Srbely, J., Shah, J., Rosenberger, W., Acuña, S., Assefa, Y., Gerber, L.H., and Sikdar, S. Multimodal Phenotyping of Myofascial Pain Syndrome Using Rotational Shear Wave Elastography and Clinical Network Analysis. Under review.

[S1] Gerwin, R., Lee, B.S., and Sikdar, S. Ryanodine Receptor-1 Non-Myopathic Mutant Variant Myalgic Profile as Determined by a Case-Control Study. Under review.

Funding

INOVA Health U19-11-3826 (Co-PI) Biostatistician Resource and Research for Researchers on iTHRIVE: Using Data to Improve Health (Parent award NIH 1UL1TR003015-1). PI: Dr. Jiayang Sun. 2021/02/01 – 2025/01/31.
NIH R61AT012286-01 (Co-I) Multimodal Imaging Biomarkers for Investigating Fascia, Muscle, and Vasculature in Myofascial Pain. PI: Dr. Siddhartha Sikdar. 2022/09/21 - 2027/8/31
NOAA NA23OAR0210558 (Mason PI) EXCLAIM: A Decision Support Toolkit to Mitigate Impacts of Cascading Climate Hazards. PI: Drs. John Foley (Metron, Inc) and Seiyon Lee (GMU). 2023/09/01 - 2024/02/28
LLNL (Mason PI) StatsEOS: Bayesian Calibration and Uncertainty quantification of Mixture Equations-of-State. PI: Drs. Jason Bernstein (LLNL), Seiyon Lee (GMU), and Philip Myint (LLNL). 2024/05/01 - 2027/04/30