Publications
Team Members Publications (2017 - 2023):
Pujol, A.; Brokhattingen, N.; Matambisso, G.; Mbeve, H.; Cistero, P.; Escoda, A.; Maculuve, S.; Cuna, B.; Melembe, C.; Ndimande, N.; Munguambe, H.; Montana, J.; Nhamussua, L.; Simone, W.; Tetteh, K. K. A.; Drakeley, C.; Gamain, B.; Chitnis, C. E.; Chauhan, V.; Quinto, L.; Chidimatembue, A.; Marti-Soler, H.; Galatas, B.; Guinovart, C.; Saute, F.; Aide, P.; Macete, E.; Mayor, A., Detecting temporal and spatial malaria patterns from first antenatal care visits. Nat Commun 2023, 14 (1), 4004.http://dx.doi.org/10.1038/s41467-023-39662-4
Natama, H. M.; Moncunill, G.; Vidal, M.; Rouamba, T.; Aguilar, R.; Santano, R.; Rovira-Vallbona, E.; Jimenez, A.; Some, M. A.; Sorgho, H.; Valea, I.; Coulibaly-Traore, M.; Coppel, R. L.; Cavanagh, D.; Chitnis, C. E.; Beeson, J. G.; Angov, E.; Dutta, S.; Gamain, B.; Izquierdo, L.; Mens, P. F.; Schallig, H.; Tinto, H.; Rosanas-Urgell, A.; Dobano, C., Associations between prenatal malaria exposure, maternal antibodies at birth, and malaria susceptibility during the first year of life in Burkina Faso. Infect Immun 2023, e0026823.http://dx.doi.org/10.1128/iai.00268-23
Kirosingh, A. S.; Delmastro, A.; Kakuru, A.; van der Ploeg, K.; Bhattacharya, S.; Press, K. D.; Ty, M.; Parte, L.; Kizza, J.; Muhindo, M.; Devachanne, S.; Gamain, B.; Nankya, F.; Musinguzi, K.; Rosenthal, P. J.; Feeney, M. E.; Kamya, M.; Dorsey, G.; Jagannathan, P., Malaria-specific Type 1 regulatory T cells are more abundant in first pregnancies and associated with placental malaria. EBioMedicine 2023, 95, 104772.http://dx.doi.org/10.1016/j.ebiom.2023.104772
Kawabata, C.; Adachi, R.; Gamain, B.; Tamura, T., Evaluation of Malarial Var2CSA-Displaying Baculovirus Vector in Transduction Efficiency in Human Cancer Cells. Biol Pharm Bull 2023, 46 (3), 404-411.http://dx.doi.org/10.1248/bpb.b22-00630
Chene, A.; Desrames, A.; Tomlinson, A.; Ruffie, C.; Tangy, F.; Gamain, B., An ACE2-based bimodular fusion protein enables reorientation of endogenous anti-Epstein-Barr virus antibodies towards SARS-CoV-2 Spike. J Infect Dis 2023.http://dx.doi.org/10.1093/infdis/jiad329
Brousse, C.; Rainey, N. E.; Desrames, A.; Teillaud, J. L.; Gamain, B.; Chene, A., Expression and Purification of scFv(2H7)-P18F3, a Bi-Modular Fusion Protein (BMFP) Targeting Human CD20. Bio Protoc 2023, 13 (10), e4682.http://dx.doi.org/10.21769/BioProtoc.4682
Matambisso, G.; Brokhattingen, N.; Maculuve, S.; Cistero, P.; Mbeve, H.; Escoda, A.; Miguel, J.; Buetas, E.; de Jong, I.; Cuna, B.; Melembe, C.; Ndimande, N.; Porras, G.; Chen, H.; Tetteh, K. K. A.; Drakeley, C.; Gamain, B.; Chitnis, C.; Chauhan, V.; Quinto, L.; Galatas, B.; Macete, E.; Mayor, A., Gravidity and malaria trends interact to modify P. falciparum densities and detectability in pregnancy: a 3-year prospective multi-site observational study. BMC Med 2022, 20 (1), 396.http://dx.doi.org/10.1186/s12916-022-02597-6
Gamain, B.; Brousse, C.; Rainey, N. E.; Diallo, B. K.; Paquereau, C. E.; Desrames, A.; Ceputyte, J.; Semblat, J. P.; Bertrand, O.; Gangnard, S.; Teillaud, J. L.; Chene, A., BMFPs, a versatile therapeutic tool for redirecting a preexisting Epstein-Barr virus antibody response toward defined target cells. Science Advances 2022, 8 (6), eabl4363.http://dx.doi.org/10.1126/sciadv.abl4363
Gamain, B.; Dorin-Semblat, D., Extraction and Immunoprecipitation of VAR2CSA, the PfEMP1 Associated with Placental Malaria. Methods Mol Biol 2022, 2470, 257-271.http://dx.doi.org/10.1007/978-1-0716-2189-9_19
Keitany, G. J.; Jenkins, B. J.; Obiakor, H. T.; Daniel, S.; Muehlenbachs, A.; Semblat, J. P.; Gamain, B.; Doritchamou, J. Y. A.; Desai, S. A.; MacDonald, N. J.; Narum, D. L.; Morrison, R.; Saveria, T.; Vignali, M.; Oleinikov, A. V.; Fried, M.; Duffy, P. E., An invariant protein that co-localizes with VAR2CSA on Plasmodium falciparum-infected red cells binds to chondroitin sulfate A. J Infect Dis 2022. http://dx.doi.org/10.1093/infdis/jiab550
Alvarez, C. L.; Chene, A.; Semblat, J. P.; Gamain, B.; Lapoumeroulie, C.; Fader, C. M.; Hattab, C.; Sevigny, J.; Denis, M. F. L.; Lauri, N.; Ostuni, M. A.; Schwarzbaum, P. J., Homeostasis of extracellular ATP in uninfected RBCs from a Plasmodium falciparum culture and derived microparticles. Biochim Biophys Acta Biomembr 2022, 1864 (10), 183980.http://dx.doi.org/10.1016/j.bbamem.2022.183980
Gamain, B.; Chene, A.; Viebig, N. K.; Tuikue Ndam, N.; Nielsen, M. A., Progress and Insights Toward an Effective Placental Malaria Vaccine. Front Immunol 2021, 12, 634508.http://dx.doi.org/10.3389/fimmu.2021.634508
Tomlinson, A.; Semblat, J. P.; Gamain, B.; Chene, A., VAR2CSA-Mediated Host Defense Evasion of Plasmodium falciparum Infected Erythrocytes in Placental Malaria. Front Immunol 2021, 11, 624126.http://dx.doi.org/10.3389/fimmu.2020.624126
Alonso, S.; Vidal, M.; Ruiz-Olalla, G.; Gonzalez, R.; Jairoce, C.; Manaca, M. N.; Vazquez-Santiago, M.; Balcells, R.; Vala, A.; Ruperez, M.; Cistero, P.; Fuente-Soro, L.; Angov, E.; Coppel, R. L.; Gamain, B.; Cavanagh, D.; Beeson, J. G.; Nhacolo, A.; Sevene, E.; Aponte, J. J.; Macete, E.; Aguilar, R.; Mayor, A.; Menendez, C.; Dobano, C.; Moncunill, G., HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women. J Infect 2021.http://dx.doi.org/10.1016/j.jinf.2021.02.024
Sirima, S. B.; Richert, L.; Chene, A.; Konate, A. T.; Campion, C.; Dechavanne, S.; Semblat, J. P.; Benhamouda, N.; Bahuaud, M.; Loulergue, P.; Ouedraogo, A.; Nebie, I.; Kabore, M.; Kargougou, D.; Barry, A.; Ouattara, S. M.; Boilet, V.; Allais, F.; Roguet, G.; Havelange, N.; Lopez-Perez, E.; Kuppers, A.; Konate, E.; Roussillon, C.; Kante, M.; Belarbi, L.; Diarra, A.; Henry, N.; Soulama, I.; Ouedraogo, A.; Esperou, H.; Leroy, O.; Batteux, F.; Tartour, E.; Viebig, N. K.; Thiebaut, R.; Launay, O.; Gamain, B., PRIMVAC vaccine adjuvanted with Alhydrogel or GLA-SE to prevent placental malaria: a first-in-human, randomised, double-blind, placebo-controlled study. Lancet Infect Dis 2020, 20 (5), 585-597.http://dx.doi.org/10.1016/S1473-3099(19)30739-X
Lee, W. C.; Russell, B.; Sobota, R. M.; Ghaffar, K.; Howland, S. W.; Wong, Z. X.; Maier, A. G.; Dorin-Semblat, D.; Biswas, S.; Gamain, B.; Lau, Y. L.; Malleret, B.; Chu, C.; Nosten, F.; Renia, L., Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis. Elife 2020, 9.http://dx.doi.org/10.7554/eLife.51546
Davies, H.; Belda, H.; Broncel, M.; Ye, X.; Bisson, C.; Introini, V.; Dorin-Semblat, D.; Semblat, J. P.; Tiburcio, M.; Gamain, B.; Kaforou, M.; Treeck, M., An exported kinase family mediates species-specific erythrocyte remodelling and virulence in human malaria. Nat Microbiol 2020, 5 (6), 848-863.http://dx.doi.org/10.1038/s41564-020-0702-4
Batty, M. B.; Schittenhelm, R. B.; Dorin-Semblat, D.; Doerig, C.; Garcia-Bustos, J. F., Interaction of Plasmodium falciparum casein kinase 1 with components of host cell protein trafficking machinery. IUBMB Life 2020, 72 (6), 1243-1249.http://dx.doi.org/10.1002/iub.2294
Adderley, J. D.; John von Freyend, S.; Jackson, S. A.; Bird, M. J.; Burns, A. L.; Anar, B.; Metcalf, T.; Semblat, J. P.; Billker, O.; Wilson, D. W.; Doerig, C., Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention. Nat Commun 2020, 11 (1), 4015.http://dx.doi.org/10.1038/s41467-020-17829-7
Gangnard, S.; Chene, A.; Dechavanne, S.; Srivastava, A.; Avril, M.; Smith, J. D.; Gamain, B., VAR2CSA binding phenotype has ancient origin and arose before Plasmodium falciparum crossed to humans: implications in placental malaria vaccine design. Sci Rep 2019, 9 (1), 16978.http://dx.doi.org/10.1038/s41598-019-53334-8
Dorin-Semblat, D.; Tetard, M.; Claes, A.; Semblat, J. P.; Dechavanne, S.; Fourati, Z.; Hamelin, R.; Armand, F.; Matesic, G.; Nunes-Silva, S.; Srivastava, A.; Gangnard, S.; Lopez-Rubio, J. J.; Moniatte, M.; Doerig, C.; Scherf, A.; Gamain, B., Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA. PLoS Biol 2019, 17 (6), e3000308.http://dx.doi.org/10.1371/journal.pbio.3000308
Dobano, C.; Ubillos, I.; Jairoce, C.; Gyan, B.; Vidal, M.; Jimenez, A.; Santano, R.; Dosoo, D.; Nhabomba, A. J.; Ayestaran, A.; Aguilar, R.; Williams, N. A.; Diez-Padrisa, N.; Lanar, D.; Chauhan, V.; Chitnis, C.; Dutta, S.; Gaur, D.; Angov, E.; Asante, K. P.; Owusu-Agyei, S.; Valim, C.; Gamain, B.; Coppel, R. L.; Cavanagh, D.; Beeson, J. G.; Campo, J. J.; Moncunill, G., RTS,S/AS01E immunization increases antibody responses to vaccine-unrelated Plasmodium falciparum antigens associated with protection against clinical malaria in African children: a case-control study. BMC Med 2019, 17 (1), 157.http://dx.doi.org/10.1186/s12916-019-1378-6
Dobano, C.; Santano, R.; Vidal, M.; Jimenez, A.; Jairoce, C.; Ubillos, I.; Dosoo, D.; Aguilar, R.; Williams, N. A.; Diez-Padrisa, N.; Ayestaran, A.; Valim, C.; Asante, K. P.; Owusu-Agyei, S.; Lanar, D.; Chauhan, V.; Chitnis, C.; Dutta, S.; Angov, E.; Gamain, B.; Coppel, R. L.; Beeson, J. G.; Reiling, L.; Gaur, D.; Cavanagh, D.; Gyan, B.; Nhabomba, A. J.; Campo, J. J.; Moncunill, G., Differential Patterns of IgG Subclass Responses to Plasmodium falciparum Antigens in Relation to Malaria Protection and RTS,S Vaccination. Front Immunol 2019, 10, 439.http://dx.doi.org/10.3389/fimmu.2019.00439
Chene, A.; Gangnard, S.; Guadall, A.; Ginisty, H.; Leroy, O.; Havelange, N.; Viebig, N. K.; Gamain, B., Preclinical immunogenicity and safety of the cGMP-grade placental malaria vaccine PRIMVAC. EBioMedicine 2019, 42, 145-156.http://dx.doi.org/10.1016/j.ebiom.2019.03.010
Chauvet, M.; Tetard, M.; Cottrell, G.; Aussenac, F.; Brossier, E.; Denoyel, L.; Hanny, M.; Lohezic, M.; Milet, J.; Ndam, N. T.; Pineau, D.; Roman, J.; Luty, A. J. F.; Gamain, B.; Migot-Nabias, F.; Merckx, A., Impact of Hemoglobin S Trait on Cell Surface Antibody Recognition of Plasmodium falciparum-Infected Erythrocytes in Pregnancy-Associated Malaria. Open Forum Infect Dis 2019, 6 (4), ofz156.http://dx.doi.org/10.1093/ofid/ofz156
Ubillos, I.; Jimenez, A.; Vidal, M.; Bowyer, P. W.; Gaur, D.; Dutta, S.; Gamain, B.; Coppel, R.; Chauhan, V.; Lanar, D.; Chitnis, C.; Angov, E.; Beeson, J.; Cavanagh, D.; Campo, J. J.; Aguilar, R.; Dobano, C., Optimization of incubation conditions of Plasmodium falciparum antibody multiplex assays to measure IgG, IgG1-4, IgM and IgE using standard and customized reference pools for sero-epidemiological and vaccine studies. Malar J 2018, 17 (1), 219.http://dx.doi.org/10.1186/s12936-018-2369-3
Pease, B. N.; Huttlin, E. L.; Jedrychowski, M. P.; Dorin-Semblat, D.; Sebastiani, D.; Segarra, D. T.; Roberts, B. F.; Chakrabarti, R.; Doerig, C.; Gygi, S. P.; Chakrabarti, D., Characterization of Plasmodium falciparum Atypical Kinase PfPK7(-) Dependent Phosphoproteome. J Proteome Res 2018, 17 (6), 2112-2123.http://dx.doi.org/10.1021/acs.jproteome.8b00062
Marginedas-Freixa, I.; Alvarez, C. L.; Moras, M.; Hattab, C.; Bouyer, G.; Chene, A.; Lefevre, S. D.; Le Van Kim, C.; Bihel, F.; Schwarzbaum, P. J.; Ostuni, M. A., Induction of ATP Release, PPIX Transport, and Cholesterol Uptake by Human Red Blood Cells Using a New Family of TSPO Ligands. Int J Mol Sci 2018, 19 (10).http://dx.doi.org/10.3390/ijms19103098
Lansche, C.; Dasanna, A. K.; Quadt, K.; Frohlich, B.; Missirlis, D.; Tetard, M.; Gamain, B.; Buchholz, B.; Sanchez, C. P.; Tanaka, M.; Schwarz, U. S.; Lanzer, M., The sickle cell trait affects contact dynamics and endothelial cell activation in Plasmodium falciparum-infected erythrocytes. Commun Biol 2018, 1, 211.http://dx.doi.org/10.1038/s42003-018-0223-3
Chene, A.; Gangnard, S.; Dechavanne, C.; Dechavanne, S.; Srivastava, A.; Tetard, M.; Hundt, S.; Leroy, O.; Havelange, N.; Viebig, N. K.; Gamain, B., Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine development. NPJ vaccines 2018, 3, 28.http://dx.doi.org/10.1038/s41541-018-0064-6
Tuikue Ndam, N.; Moussiliou, A.; Lavstsen, T.; Kamaliddin, C.; Jensen, A. T. R.; Mama, A.; Tahar, R.; Wang, C. W.; Jespersen, J. S.; Alao, J. M.; Gamain, B.; Theander, T. G.; Deloron, P., Parasites Causing Cerebral Falciparum Malaria Bind Multiple Endothelial Receptors and Express EPCR and ICAM-1-Binding PfEMP1. J Infect Dis 2017, 215 (12), 1918-1925.http://dx.doi.org/10.1093/infdis/jix230
Tetard, M.; Milet, J.; Dechavanne, S.; Fievet, N.; Dorin-Semblat, D.; Elion, J.; Fairhurst, R. M.; Deloron, P.; Tuikue-Ndam, N.; Gamain, B., Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria. Sci Rep 2017, 7 (1), 1414.http://dx.doi.org/10.1038/s41598-017-01495-9
Mahamar, A.; Attaher, O.; Swihart, B.; Barry, A.; Diarra, B. S.; Kanoute, M. B.; Cisse, K. B.; Dembele, A. B.; Keita, S.; Gamain, B.; Gaoussou, S.; Issiaka, D.; Dicko, A.; Duffy, P. E.; Fried, M., Host factors that modify Plasmodium falciparum adhesion to endothelial receptors. Sci Rep 2017, 7 (1), 13872.http://dx.doi.org/10.1038/s41598-017-14351-7
Lennartz, F.; Adams, Y.; Bengtsson, A.; Olsen, R. W.; Turner, L.; Ndam, N. T.; Ecklu-Mensah, G.; Moussiliou, A.; Ofori, M. F.; Gamain, B.; Lusingu, J. P.; Petersen, J. E.; Wang, C. W.; Nunes-Silva, S.; Jespersen, J. S.; Lau, C. K.; Theander, T. G.; Lavstsen, T.; Hviid, L.; Higgins, M. K.; Jensen, A. T., Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria. Cell Host Microbe 2017, 21 (3), 403-414.http://dx.doi.org/S1931-3128(17)30071-9
John Von Freyend, S.; Kwok-Schuelein, T.; Netter, H. J.; Haqshenas, G.; Semblat, J. P.; Doerig, C., Subverting Host Cell P21-Activated Kinase: A Case of Convergent Evolution across Pathogens. Pathogens 2017, 6 (2).http://dx.doi.org/10.3390/pathogens6020017