Beauty Is A Wound Pdf Download !FULL!

The ambivalence about beauty at the heart of western culture begins at the beginning. In Jerusalem, proscriptions against idols and graven images coexist with paeans to the craftsmanship of God and Bezalel, the artificer (described in Exodus) of the desert tabernacle. In Athens, Plato celebrates the divine madness that the poet experiences when the muse descends, but he also kicks the poets out of his ideal republic as unreliable, disruptive sorts.

But beauty, von Balthasar says, is disinterested. It has no agenda. Beauty can sail under the radar of our anxious contention over what is true and what is good, carrying along its beam a ray of the beatific vision. Beauty can pierce the heart, wounding us with the transcendent glory of God.

Beauty Is A Wound Pdf Download

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But the transcendentals were always understood as infinitely valuable, as ends in themselves. When it comes to beauty, however, we are afraid to assert that much. We feel the need to harness it, because beauty is unpredictable, wild.

Beauty tutors our compassion, making us more prone to love and to see the attraction of goodness. Art takes us out of our self-referentiality and invites us to see through the eyes of the other, whether that other is the artist herself or a character in a story. Because beauty endows goodness with mercy, it enables us to see how difficult it is to achieve goodness, how often one good exists in tension with another. Our pursuit of the good is inherently dramatic, and drama is based on conflict.

Perhaps it goes without saying, but any serious discussion of beauty needs to treat it as something more than prettiness. The Greeks, as I have suggested, were deeply divided about beauty. They loved harmony, proportion, symmetry, the ideal form. But they also knew darkness, as their tragedies attest.

A recognition of beauty is evident when a crowd of babbling tourists move from the parking lot at a Glacier Point in Yosemite and go totally silent when they approach the viewing site. A sort of holy awe sweeps over the mass and they tip- toe silently away and resume dialogue out of earshot.

NT Wright defines beauty as one of four universal God characteristics that is embedded in our DNA.

Aloe vera is a medicinal plant traditionally used since 1500 BC in many countries such as Greece, China, and Mexico. It also has been used for centuries as a traditional medicine for various diseasesand skin lesions.3 Aloe vera is an indigenous plant from tropical Madagascar, Saudi Arabia, and Iran. It belongs to the Liliaceae family; it is similarto Cactus and is an herbaceous and perennial plant with thick, fleshy and long leaves. The Egyptian queens Nefertiti and Cleopatra used Aloe vera as part of their regular beauty regime.4 So far,75 known compounds have been identified in Aloe vera, including 20 minerals, 20 amino acids, vitamins, and water.5,6 In vitrostudies and studies conducted on living organisms have shown that Aloe vera can inhibit thromboxane (an inhibitor of wound healing), improve the wound healing process,and reduce inflammation.3,7 Magnesium lactate available in the gel can prevent the production of histamine that causesitching and irritation of the skin.8,9 It also enhances the immune system and the synthesis of cytokines.Aloe vera is effective in inhibiting inflammatory reactions by the inhibition of IL-6 and IL-8, the reduction of leukocyte adhesion, an increase of IL-10 levels, and decrease of TNF alphalevels.10 Its regenerative properties are due to the compound glucomannan, which is rich with polysaccharides like mannose. Glucomannanaffects fibroblast growth factor receptors and stimulates their activity and proliferation, which in turn increases the production of collagen. Aloe vera gel can not only increase the amountof collagen in wounds but also change the composition of collagen, increase collagen cross-linking and thereby promote wound healing.11 Scientificstudies have shown that the gel can increase the flexibility and reduce the fragility of the skin since 99% of the gel is water.4 Additionally,mucopolysaccharides along with amino acids and zinc present in Aloe vera can lead to skin integrity, moisture retention, erythema reduction, and helps to prevent skin ulcers.12 Severalstudies have shown the positive effects of Aloe vera to treat wounds such as psoriasis, mouth sores, ulcers, diabetes, herpes, bedsores, and burnwounds.1,4,6,13-15 Aloevera is known for its anti-tumor, anti-inflammatory, skin protection, anti-diabetic, anti-bacterial, anti-viral, antiseptic, and wound healing properties.6

Wound healing and preventive effects of Aloe vera have been reported in several studies.16 Topical application of Aloe vera to prevent ulcers and enhance the healing process of dermal injuries (e.g., burns, frostbite, skin infections, surgical wounds, inflammation, herpes ulcers, diabetic foot ulcers, pressure sores, and chronic wounds) has been reported.17 Aloe vera is highly suitable for wound dressings.18 Most of the studies were conducted on burn wounds. Aloe vera is considered as the traditional therapy for burns. Five studies investigated burn wound healing. In these studies, Aloe vera was more effective than petroleum jelly gauze dressing, silver sulfadiazine 1% ointment, and framycetin cream. Moreover, it reduced the recovery time, prevented infection in the wound area, and prevented redness and itching.4,14,19-21 In these studies, Aloe vera was more effective in first- and second-degree burn wounds than in the other degrees. As described in Table 1, it is concluded that Aloe vera can reduce the healing time of first- and second-degree burns to 9 days (P=0.006).15

As described in Table 2, Aloe vera was used on postoperative wounds such as episiotomy, cesarean section, skin biopsy, hemorrhoidectomy, gynecologic laparotomy surgery, and graft.22-28 In these studies, the use of Aloe vera gel and cream reduced the pain and recovery time compared to other conventional treatments. Only one study group, Aloe vera dressing for skin shave biopsy, did not show any difference in terms of improvement compared to the combined dressing group.27

Aloe vera has been effective in chronic wounds such as pressure ulcers, diabetic ulcers, chronic anal fissure wounds, chronic wounds caused by accidents, psoriasis, and genital herpes. In this regard, 7 articles were studied and Aloe vera was more effective compared to saline gauze dressing, phenytoin, and current treatments.31-37 Only in one study, no differences were found between the two groups which can be due to the small sample size compared to the other studies.36 Aloe vera reduced the pain, bleeding, and recovery time in chronic wounds (Table 4).

Aloe vera gel or cream on postoperative wounds (three times a day for 5-10 days) could reduce pain and recovery time.22-28 Only one study indicated that there was no difference between the experimental and placebo groups.28 This could be due to inappropriate placebo or the optimal time point for improvement. Cracked nipples could also be treated using Aloe vera if applied 3 times a day or after each breastfeeding. It would reduce the pain due to cracked nipples.29,30 This finding was also confirmed in a study by Eshgizade and colleagues (2016).40

It is indicated that Aloe vera (as a gel or cream) can be effective to treat chronic wounds such as psoriasis lesions (twice a day for 4-8 weeks),34,37 pressure ulcers (1-3 months), venous, diabetic,31,32 and herpes ulcers and chronic anal fissure (2-3 weeks).33-36 In these articles, in addition to the recovery time, the following factors were also checked: Lesion scores;34 depth, size, edema around the wound area, the amount of exudate and necrotic tissue,32 inflammation,34,37 pain and bleeding,33 and infection.19 It was shown that Aloe vera could have a positive effect on the above-mentioned factors and their reduction. Only Thomas and colleagues found no healing difference between saline and Aloe vera in the treatment of pressure ulcers. Perhaps the small sample size (30 cases) was the reason behind their findings.35 As the secondary objective, many studies measured the length of hospitalization, cost of scar treatment, and redness and itching of the wound area. They indicated that Aloe vera is superior to other treatments.14,21,31

Several studies noted the traditional belief that a wound should not be covered, allowing it to become dry and detach itself from the wound area since it inhibits the migration of cells and growth factors leading to wound healing. Aloe vera as a wound cover would keep the wound area moist and allows optimal migration of fibroblasts and epidermal. Aloe vera (1 to 100 mg/kg) can improve wound healing.41

"In a pandemic situation, it is important for any outpatient wound program to rapidly identify the entire patient cohort that it has been managing and determine optimal strategies to manage patients, preferably at home, ... Read More

Chronic wounds represent a major challenge to the present healthcare system. In recent decades, many topical therapies have been investigated for the treatment of chronic wounds, including different types of wound dressings, antimicrobial agents, and cell therapy. Platelet-derived growth factor (PDGF) plays an important role in wound healing and has been approved for treatment of wounds related to diabetes mellitus. However, the high cost and short retention time of PDGF protein have limited its wide application. To overcome this challenge, we designed a PDGF-mimicking peptide by connecting PDGF epitope VRKIEIVRKK and self-assembling motif derived from -amyloid peptide. The resultant peptide can self-assemble into a fibril-rich network and leads to supramolecular hydrogelation with good stability. The hydrophilic epitope can be exposed on the surface of nanofibrils, which might contribute to the binding and activation of PDGF receptors. The forming hydrogel is able to induce the growth and migration of vascular endothelial cells and promote the formation of vascular branches. In the full-thickness skin wounds of healthy mice, after the application of the hydrogel, the density of neovascularization marked by CD31 was greater than that in the control group on Day 3. Larger collagen deposition and a thicker epidermis were observed on Day 12. These results demonstrate that the hydrogel can stimulate collagen deposition and angiogenesis, enhance skin regeneration, and show an excellent therapeutic effect. Taken together, this work not only provides new insight into the design of bioactive peptides but also offers a promising biomaterial for wound healing. 2351a5e196