Publications

International Journals

* Denotes co-first author

† Denotes co-corresponding author

   Lab trainees are underlined.

[2025]

• Hye-Yeon Ju, Hyundong Yoon, Seungpil Jung, Serk In Park†, Tae Kon Kim†, Mi-Ryung Han†: Systemic chemotherapy in metastatic TNBC polarizes effector T cell differentiation. Cancer Cell International (Accepted) († co-corresponding author)

• Young-Hoon Park*, Seong-Woo Park*, Jee-Whan Kim, Yoo-Kyung Lee, Han-Byoul Cho, In-Ho Park, Mi-Ryung Han†, Jae-Hoon Kim†: Genomic alterations linked to recurrence risk in high-grade serous ovarian cancer revealed by deep targeted sequencing. (In revision) (* co-first author, † co-corresponding author)

• Johyeon Nam, Mi-Ryung Han: Single-cell RNA sequencing reveals a putative lncRNA-associated ceRNA network in high-grade serous ovarian cancer. Genes & Genomics (Accepted)

• Johyeon Nam, Hongseong Shin, Chaeyeon You, Eunha Baeg, Jae Geun Kim, Sunggu Yang† and Mi-Ryung Han†: Cortical Stimulation-Based Transcriptome Shifts on Parkinson’s Disease Animal Model. ASN Neuro 2025 June 16;17(1). doi.org/10.1080/17590914.2025.2513881. († co-corresponding author)

• Hye Rim Yang*, Mi-Ryung Han*, Eun-Young Oh, Ja Yeon Choi, Jae Yeon Choi, Yuhyun Kim, Yang Tae Kim, Hara Kang and Jae Geun Kim: Role of Cold-Inducible RNA-Binding Protein in Hypothalamic Regulation of Feeding Behavior during Fasting and Cold Exposure. Biochemical and Biophysical Research Communications 2025 April 9:757:151616. doi: 10.1016/j.bbrc.2025.151616. (* co-first author)

• Hongseong Shin, Kyungtae Kim, Jaeseung Lee, Johyeon Nam, Eunha Baeg, Chaeyeon You, Hanseul Choi, Minji Kim, Chun Kee Chung, Jae Geun Kim, Jong Hyun Ahn, Miryung Han, Jibum Kim, Sungchil Yang, Sung Q Lee, Sunggu Yang: A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals. Advanced Healthcare Materials 2025 April 8:e2405179. doi: 10.1002/adhm.202405179. 

[2024]

• Mi-Ryung Han*, Joo Hee Jeong*, Yun Gi Kim, Hyun-Ho Yang, Chang-Ok Seo, Yeji Kim, Hyoung Seok Lee, Jaemin Shim, Young-Hoon Kim, Jong-Il Choi: Epigenetic Regulation on Left Atrial Function and Disease Recurrence After Catheter Ablation in Atrial Fibrillation. Clinical Epigenetics 2024 December 18;16(1):183. doi: 10.1186/s13148-024-01794-9.

• Daun Shin, Youbin Kang, Aram Kim, Woo Suk Tae, Mi-Ryung Han, Kyu-Man Han, Byung-Joo Ham: The Effect of Forkhead Box O1 Single Nucleotide Polymorphisms on Cortical Thickness and White Matter Integrity in High Suicide Risk Patients. Psychiatry Investigation 2024 November 21(11):1238-1250. doi: 10.30773/pi.2024.0044.

• Hyun-Ho Yang, Mi-Ryung Han: MethylCallR : a comprehensive analysis framework for Illumina Methylation Beadchip. Scientific Reports 2024 November 7;14(1):27026. doi: 10.1038/s41598-024-77914-5. https://github.com/Yang9704/MethylCallR

• Ju Won Kim*, So-Hyun Bae*, Yesol Moon, Eun Kyung Kim, Yongjin Kim, Yun Gyu Park, Mi-Ryung Han†, Jeongwon Sohn†: Transcriptomic analysis of cellular senescence induced by ectopic expression of ATF6α in human breast cancer cells. PLoS One 2024 October 28;19(10):e0309749. doi: 10.1371/journal.pone.0309749. (* co-first author, † co-corresponding author)

• Hye-Yeon Ju*, Seo Yeon Youn*, Jun Kang, Min Yeop Whang, Youn Jin Choi† and Mi-Ryung Han†: Integrated analysis of spatial transcriptomics and CT phenotypes for unveiling the novel molecular characteristics of recurrent and non-recurrent high-grade serous ovarian cancer. Biomarker Research 2024 August 12;12(1):80. doi: 10.1186/s40364-024-00632-7. († co-corresponding author)

• Seong-Woo Park, Mi-Ryung Han: A pan-cancer analysis unveiling the function of NR4A family genes in tumor immune microenvironment, prognosis, and drug response. Genes & Genomics 2024 July 8. doi: 10.1007/s13258-024-01539-1.  

• Garam Choi*, Hye-Yeon Ju*, Jahyun Bok*, Jungseo Choi, Jae Woo Shin, Hansol Oh, Yeojin Jeon, Jiyeon Kim, Daehong Kim, Heesu Moon, Jeong-Eun Lee, Young-Sam Keum, You-Me Kim, Hye Young Kim, Sung Ho Park†, Mi-Ryung Han† and Yeonseok Chung†: NRF2 is a spatiotemporal metabolic hub essential for the polyfunctionality of Th2 cells. Proceedings of the National Academy of Sciences (PNAS) 2024 July 9;121(28):e2319994121. doi: 10.1073/pnas.2319994121. (* co-first author, † co-corresponding author)

• Hyun-Ho Yang*, Kyu-Man Han*, Aram Kim, Youbin Kang, Woo-Suk Tae, Mi-Ryung Han†, Byung-Joo Ham†: Neuroimaging and epigenetic analysis reveal novel epigenetic loci in major depressive disorder. Psychological Medicine 2024 July;54(10):2585-2598. doi: 10.1017/S0033291724000709. († co-corresponding author)

• Eun-Young Oh*, Kyu-Man Han*, Aram Kim, Youbin Kang, Woo-Suk Tae, Mi-Ryung Han†, Byung-Joo Ham†: Integration of Whole-Exome Sequencing and Structural Neuroimaging Analysis in Major Depressive Disorder: A Joint Study. Translational Psychiatry 2024 March 9; 14(1), 141. doi: 10.1038/s41398-024-02849-4. († co-corresponding author)

[2023]

• So-Hyun Bae, Taewon Hwang, Mi-Ryung Han: Unraveling the hypoxia modulating potential of VEGF family genes in pan-cancer. Genomics & Informatics 2023 September 27; 21(4), e44

• Boram Choi, Yoojin Na, Min Yeop Whang, Jung Yoon Ho, Mi-Ryung Han, Seong-Woo Park, Heekyoung Song, Soo Young Hur , Youn Jin Choi: MGMT methylation is associated with human papillomavirus infection in cervical intraepithelial neoplasia: a longitudinal study. Journal of Clinical Medicine 2023 September 25; 12(19), 6188

• Ah Young Park*, Mi-Ryung Han*, Bo Kyoung Seo, Hye-Yeon Ju, Gil Soo Son, Hye Yoon Lee, Young Woo Chang, Jungyoon Choi, Kyu Ran Cho, Sung Eun Song, Ok Hee Woo, Hyun Soo Park: MRI-based breast cancer radiogenomics using RNA profiling: association with subtypes in a single-center prospective study. Breast Cancer Research 2023 Jun 30; 25(1): 79 (* co-first author)

• Mi-Ryung Han*, Ah Young Park*, Bo Kyoung Seo, Min Sun Bae, Jung Sun Kim, Gil Soo Son, Hye Yoon Lee, Young Woo Chang, Kyu Ran Cho, Sung Eun Song, Ok Hee Woo, Hye-Yeon Ju, Hyunseung Oh: Association between vascular ultrasound features and DNA sequencing in breast cancer: A preliminary study. Discover Oncology 2023 April 30; 14(1): 52 (* co-first author)

• Eun-Young Oh*, Byong Seo Park*, Hye Rim Yang, Ho Gyun Lee, Thai Hien Tu, Sunggu Yang, Mi-Ryung Han† and Jae Geun Kim†: Whole Transcriptome Analysis of Hypothalamus in Mice during Short-Term Starvation. International Journal of Molecular Sciences 2023 February 6; 24(4), 3204 († co-corresponding author)

• Seong Eun Bak, Hanwool Kim, Jung Yoon Ho, Eun-Hae Cho, Junnam Lee, Sung Min Youn, Seong-Woo Park, Mi-Ryung Han, Soo Young Hur, Sung Jong Lee and Youn Jin Choi: Shallow Whole-Genome Sequencing of Cell-Free DNA (cfDNA) Detects Epithelial Ovarian Cancer and Predicts Patient Prognosis. Cancers 2023 January 15; 15(2), 530

[2022]

• Yuyeon Jung, Taewan Kim, Mi-Ryung Han, Sejin Kim, Geunyoung Kim, Seungchul Lee & Youn Jin Choi: Ovarian tumor diagnosis using deep convolutional neural networks and a denoising convolutional autoencoder. Scientific Reports 2022 October 11; 12(1), 17024

• Kyu-Man Han*, Kwan Woo Choi*, Aram Kim, Wooyoung Kang, Youbin Kang, Woo-Suk Tae, Mi-Ryung Han† and Byung-Joo Ham†: Association of DNA methylation of the NLRP3 gene with changes in cortical thickness in major depressive disorder. International Journal of Molecular Sciences 2022 May 22; 23(10), 5768 († co-corresponding author)

• Hye-Yeon Ju, Jung Yoon Ho, Jun Kang, Soo Young Hur, Sejin Kim, Youn Jin Choi† and Mi-Ryung Han†: Whole-Exome Sequencing Reveals Clinical Potential of Circulating Tumor DNA from Peritoneal Fluid and Plasma in Endometrial Cancer. Cancers 2022 May 19; 14(10), 2506 († co-corresponding author)

[2021]

• Mi-Ryung Han: Rare Coding Variants Associated with Breast Cancer. Advances in Experimental Medicine and Biology 2021 May 14;1187:435-453

• Ah Young Park, Bo Kyoung Seo, Mi-Ryung Han: Breast ultrasound microvascular imaging and radiogenomics. Korean Journal of Radiology 2021 January 19; 22(5):677-687

[2020]

• Seung-Hyun Jung*, Youn Jin Choi*, Min Sung Kim, Hyeon-Chun Park, Mi-Ryung Han, Soo Young Hur, Ah Won Lee, Ok Ran Shin, Jeana Kim, Sung Hak Lee, Dongwan Hong, Sang Yong Song, Yeun-Jun Chung and Sug Hyung Lee: Distinct genomic profiles of gestational choriocarcinoma, a unique cancer from pregnant tissues. Experimental & Molecular Medicine 2020 December 15; 52:2046–2054

• Kijeong Lee*, Mi-Ryung Han*, JiWoo Yeon, Byoungjae Kim and Tae Hoon Kim: Whole Transcriptome Analysis of Myeloid Dendritic Cells Reveals Distinct Genetic Regulation in Patients with Allergies. International Journal of Molecular Sciences 2020 November 16; 21(22): 8640 (* co-first author)

• Sung-Hee Hwang, Hojin Yeom, Byeal-I Han, Byung-Joo Ham, Yong-Moon Lee, Mi-Ryung Han† and Michael Lee†: Predicting Carcinogenic Mechanisms of Non-Genotoxic Carcinogens via Combined Analysis of Global DNA Methylation and In Vitro Cell Transformation. International Journal of Molecular Sciences 2020 July 29; 21(15): 5387 († co-corresponding author)

• Ah Young Park*, Mi-Ryung Han*, Kyong Hwa Park, Jung Sun Kim, Gil Soo Son, Hye Yoon Lee, Young Woo Chang, Eun Kyung Park, Sang Hoon Cha, Yunjung Cho, Hyosun Hong, Kyu Ran Cho, Sung Eun Song, Ok Hee Woo, Ju-Han Lee, Jaehyung Cha, Bo Kyoung Seo: Radiogenomic Analysis of Breast Cancer using B-mode and Vascular US and RNA Sequencing. Radiology 2020 April 4; 295(1):24-34 (* co-first author)

• Mi-Ryung Han, Sug Hyung Lee, Jung Yoon Park, Hyosun Hong, Jung Yoon Ho, Soo Young Hur, Youn Jin Choi: Clinical Implications of Circulating Tumor DNA from Ascites and Serial Plasma in Ovarian Cancer. Cancer Research and Treatment 2020 February 28; doi: 10.4143/crt.2019.700.

• Kyu-Man Han*, Mi-Ryung Han*, Aram Kim, Wooyoung Kang, Youbin Kang, June Kang, Woo-Suk Tae, Yunjung Cho, Byung-Joo Ham: A study combining whole-exome sequencing and structural neuroimaging analysis for major depressive disorder. Journal of Affective Disorders 2020 February 1; 262:31-39 (* co-first author)

[2019]

• Mi-Ryung Han*, Kyu-Man Han*, Aram Kim, Wooyoung Kang, Youbin Kang, June Kang, Eunsoo Won, Woo-Suk Tae, Yunjung Cho, Byung-Joo Ham: Whole-exome sequencing identifies variants associated with structural MRI markers in patients with bipolar disorders. Journal of Affective Disorders 2019 April 15; 249:159-168 (* co-first author)

[2018]

• Sun Shin, Hyeon-Chun Park, Min Sung Kim, Mi-Ryung Han, Sung Hak Lee, Seung Hyun Jung, Sug Hyung Lee and Yeun-Jun Chung: Whole-exome sequencing identified mutational profiles of squamous cell carcinomas of anus. Human Pathology 2018 October; 80:1-10

• Xingyi Guo, Weiqiang Lin, Jiandong Bao, Qiuyin Cai, Xiao Pan, Mengqiu Bai, Yuan Yuan, Jiajun Shi, Yaqiong Sun, Mi-Ryung Han, Jing Wang, Qi Liu, Wanqing Wen, Bingshan Li, Jirong Long, Jianghua Chen, Wei Zheng: A comprehensive cis-eQTL analysis revealed target genes in breast cancer susceptibility loci identified in genome-wide association studies. American Journal of Human Genetics 2018 May 3; 102(5):890-903

• Mi-Ryung Han, Sun Shin, Hyeon-Chun Park, Min Sung Kim, Sung Hak Lee, Seung Hyun Jung, Sang Yong Song, Sug Hyung Lee and Yeun-Jun Chung: Mutational signatures and chromosome alteration profiles of squamous cell carcinomas of vulva. Experimental & Molecular Medicine 2018 February 9; 50(2):e442

[2017]

• Mi-Ryung Han, Wei Zheng, Qiuyin Cai, Yu-Tang Gao, Ying Zheng, Manjeet K. Bolla, Kyriaki Michailidou, Joe Dennis, Qin Wang, Alison M. Dunning, Paul Brennan, Shou-Tung Chen, Ji-Yeob Choi, Mikael Hartman, Hidemi Ito, Artitaya Lophatananon, Keitaro Matsuo, Hui Miao, Kenneth Muir, Suleeporn Sangrajrang, Chen-Yang Shen, Soo Hwang Teo, Chiu-chen Tseng, Anna H Wu, Cheng Har Yip, Daehee Kang, Yong-Bing Xiang, Douglas F. Easton, Xiao-Ou Shu, Jirong Long: Evaluating genetic variants associated with breast cancer risk in high and moderate-penetrance genes in Asians. Carcinogenesis 2017 May 1; 38(5):511-518

[2016]

• Mi-Ryung Han, Jirong Long, Ji-Yeob Choi, Siew-Kee Low, Sun-Seog Kweon, Ying Zheng, Qiuyin Cai, Jiajun Shi, Xingyi Guo, Keitaro Matsuo, Motoki Iwasaki, Chen-Yang Shen, Mi Kyung Kim, Wanqing Wen, Bingshan Li, Atsushi Takahashi, Min-Ho Shin, Yong-Bing Xiang, Hidemi Ito, Yoshio Kasuga, Dong-Young Noh, Koichi Matsuda, Min Ho Park, Yu-Tang Gao, Hiroji Iwata, Shoichiro Tsugane, Sue K. Park, Michiaki Kubo, Xiao-Ou Shu, Daehee Kang, Wei Zheng:  Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci. Human Molecular Genetics 2016 August 1; 25(15):3361-3371

[2015]

• Mi-Ryung Han, Sandra Deming-Halverson, Qiuyin Cai, Wanqing Wen, Martha J. Shrubsole, Xiao-Ou Shu, Wei Zheng, Jirong Long: Evaluating 17 breast cancer susceptibility loci in the Nashville breast health study. Breast Cancer 2015 September; 22(5):544-551

• Naomi Kouri, Owen A Ross, Beth Dombroski, Curtis S Younkin, Daniel J Serie, Alexandra Soto-Ortolaza, Matthew Baker, NiCole A Finch, Hyejin Yoon, Jungsu Kim, Shinsuke Fujioka, Catriona A McLean, Bernardino Ghetti, Salvatore Spina, Martin R. Farlow, Jordan H. Grafman, Edward D. Huey, Laura B Cantwell, Mi Ryung Han, (34 authors), Dennis W Dickson: Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. Nature Communications 2015 June 16; 6:7247

[2011]

• Günter U Höglinger, Nadine M Melhem, Dennis W Dickson, Patrick M A Sleiman, Li-San Wang, Lambertus Klei, Rosa Rademakers, Rohan de Silva, Irene Litvan, David E Riley, John C van Swieten, Peter Heutink, Zbigniew K Wszolek, Ryan J Uitti, Jana Vandrovcova, Howard I Hurtig, Rachel G Gross, Walter Maetzler, Stefano Goldwurm, Eduardo Tolosa, Barbara Borroni, Pau Pastor, PSP Genetics Study Group, Laura B Cantwell, Mi Ryung Han, (15 authors), Gerard D. Schellenberg. (2011) Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nature Genetics 2011 June 19; 43(7):699-705

[2010]

• Mi-Ryung Han, Gerard D. Schellenberg, Li-San Wang, the Alzheimer's Disease Neuroimaging Initiative. (2010) Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study. BMC Neurology 2010 October 8; 10:90

[2006]

• Wonshik Han, Mi-Ryung Han, Jason Jongho Kang, Ji-Yeon Bae, Ji Hyun Lee, Young Ju Bae, Jeong Eon Lee, Hyuk-Jae Shin, Ki-Tae Hwang, Sung-Eun Hwang, Sung-Won Kim, Dong-Young Noh. (2006) Genomic alterations identified by array comparative genomic hybridization as prognostic markers in tamoxifen treated estrogen receptor positive breast cancer. BMC Cancer 2006 April 12; 6:92

[2005]

• Hee-Joon Chung, Chan Hee Park, Mi Ryung Han, Seoko Lee, Jung Hun Ohn, Jihoon Kim, Jihoon Kim, Ju Han Kim. (2005) ArrayXPath II: mapping and visualizing microarray gene expression data with biomedical ontologies and integrated pathway resources using Scalable Vector Graphics. Nucleic Acids Research 2005 July 1; 33:W621-W626

• Ji-Yeon Bae, Soo-Jung Ahn, Jeong Eon Lee, Jung-Eun Kim, Mi-Ryung Han, Wonshik Han, Seok Won Kim, Hyuk Jai Shin, Seung Joon Lee, Dongeun Park, Dong-Young Noh. (2005) BetaPix-a enhances the activity of phospholipase Cgamma1 by binding SH3 domain in breast cancer. Journal of Cellular Biochemistry 2005 April 1; 94:1010-1016

Patents (Domestic & International)

• 최윤진,한미령,박성은,조혜림:  난소암 발생 예측을 위한 마커, 및 이의 용도

(대한민국 특허출원번호 10-2025-0053353 (2025.04.23))

• 한미령,최윤진,윤서연,주혜연:  고등급 장액성 난소암의 분자적 특성을 분석하는 전자장치 및 분석 방법

(대한민국 특허출원번호 10-2024-0199077 (2024.12.27))

• 최윤진,한미령,송희경,조혜림:  차세대 염기서열분석을 이용하여 자궁내막암 분자적 유형을 분류하는 시스템 및 방법

(대한민국 특허출원번호 10-2024-0114058 (2024.08.26))

• 함병주, 한미령, 한규만: 주요우울장애 진단용 DNA 메틸화 바이오마커

(대한민국 특허출원번호 10-2023-0126045 (2023.09.21))

• 한미령, 최윤진, 오은영: 전장 엑솜 시퀀싱 데이터를 이용한 상동 재조합 결핍 분류 방법 및 분석장치

(대한민국 특허출원번호 10-2023-0108609 (2023.08.18))

• 한미령, 최윤진, 오은영: 상동 재조합 결핍 관련 정보를 산출하는 방법 및 분석장치

(대한민국 특허출원번호 10-2022-0135159 (2022.10.19))

• 한미령, 최윤진, 주혜연: 액체생검 기반 자궁내막암 진단용 바이오마커 및 이의 용도

(대한민국 특허출원번호 10-2022-0118114 (2022.09.19))

• 서보경, 한미령, 박아영: 자기공명영상과 RNA 유전자 정보를 이용한 유방암 관련 정보제공 방법

(대한민국 특허출원번호 10-2022-0099468 (2022.08.09), 특허등록번호 10-2853333 (2025.8.27), PCT 해외 출원번호 PCT/KR2022/011883 (2022.08.09))

• 서보경, 한미령, 박아영: 유방암 초음파 영상을 이용한 DNA 유전자 정보를 제공하는 방법

(대한민국 특허출원번호 10-2020-0134676 (2020.10.16), 특허등록번호 10-2508210 (2023.3.6), PCT 해외 출원번호 PCT/KR2021/001477 (2021.02.04))

• 서보경, 한미령, 박아영: 유방암 초음파 영상과 유전자 정보를 이용한 유방암 치료법 선택을 위한 정보를 제공하는 방법

(대한민국 특허출원번호 10-2019-0116230 (2019.9.20), 특허등록번호 10-2405973 (2022.5.31), PCT 해외 출원번호 PCT/KR2020/012592 (2020.9.18), 미국 출원번호 17/771,939 (2022.04.26), 미국 특허등록번호 12329583 (2025.06.17))

• 서보경, 한미령, 박아영: 유방암 게놈 연구에서 검출된 마커를 사용한 유방암 진단용 키트

(대한민국 특허출원번호 10-2019-0123097 (2019.10.4))

• 최윤진, 허수영, 한미령: 난소암의 진단 또는 모니터링 방법

(대한민국 특허출원번호 10-2019-0114334 (2019.9.17), 특허등록번호 10-2257123 (2021.5.21))

• 함병주, 한미령, 한규만: 정신 질환 진단용 KMT2C 다형성 마커

(대한민국 특허출원번호 10-2018-0158136 (2018.12.10), 특허등록번호 10-2110883 (2020.5.8))