PUBLICATIONS

17. Khanppnavar B.*, Leka O.*, Pal S. K., Korkhov V. M., Kammerer R. A., Cryo-EM structure of the botulinum neurotoxin A/SV2B complex and its implication for translocation. Nature Communications (2025) 16, 1224. DOI:10.1038/s41467-025-56304-z  *Co-first authors

16. Saha S.*, Khanppnavar B.*, Maharana J.*, Kim H., Carino C. M. C., Carole Daly C., Houston S., Kumari P., Yadav P. N., Plouffe B., Inoue A., Chung K. Y., Banerjee R., Korkhov V., Shukla A. K. Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor. Cell (2024). DOI: 10.1016/j.cell.2024.07.005  *Co-first authors

15. Ding X., Aureli S., Vaithia A, Lavriha P., Schuster D., Khanppnavar B., Li X., Blum T., Gervasio F. L., Korkhov V. M. Structural basis of connexin-36 gap junction channel inhibition. Cell Discovery (2024). DOI: 10.1038/s41421-024-00691-y

14. Khanppnavar B.*, Choo J. P. S.*, Hagedoorn P. L.*, Smolentsev G., Kumaran S., Tischler D., Winkler F., Korkhov V. M., Li Z., Kammerer R., Li X. Structural basis of the Meinwald rearrangement catalyzed by styrene oxide isomerase. Nature Chemistry (2024). https://doi.org/10.1038/s41557-024-01523-y *Co-first authors

13. Holfeld A., Schuster D., Sesterhenn F., Stalder P., Haenseler W., Barrio-Hernandez I., Ghosh D., Nagel L., Khanppnavar B., Beltrao P., Korkhov V., Riek R., Souza N. D., Picotti P. Systematic identification of structure-specific protein-protein interactions using limited proteolysis–mass spectrometry. Molecular Systems Biology (2024). https://doi.org/10.1038/s44320-024-00037-6 

12. Khanppnavar B.*, Schuster D.*, Lavriha P., Uliana F., Özel M., Ved Mehta V., Leitner A., Picotti P., Korkhov V. M. Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics. EMBO reports (2024). https://doi.org/10.1038/s44319-024-00076-y  *Co-first authors

11. Khanppnavar B.#, North RA.#, Ventura S.#, Xu Y.# Advances, challenges, and opportunities in structural biology. Trends in Biochemical Sciences (2024). https://doi.org/10.1016/j.tibs.2023.12.006  #Corresponding authors

10. Schuster D., Khanppnavar B., Kantarci I., Mehta V., Korkhov V. M Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling. Trends in Biochemical Sciences (2023). https://doi.org/10.1016/j.tibs.2023.12.002 

9. Khanppnavar B.*, Maier J.*, Herborg F., Gradisch R., Lazzarin E., Luethi D., Yang J. W., Qi C., Holy M., Jäntsch K., Kudlacek O., Schicker K., Werge T., Gether U., Stockner T., Korkhov V. M., Sitte H. H. Structure basis of inhibition of organic cation transporter OCT3. Nature Communications (2022) 13, 6714. https://doi.org/10.1038/s41467-022-34284-8  *Co-first authors

8. Mehta V.*, Khanppnavar B.*, Schuster D., Kantarci I., Vercellino I., Kosturanova A., Iype T., Stefanic S., Picotti P., Korkhov V. M. Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases. eLife (2022) 11:e77032. https://doi.org/10.7554/eLife.77032 *Co-first authors 

7. Choudhury A*., Khanppnavar B.*, Datta S. Crystallographic and biophysical analyses of Pseudomonas aeruginosa ketopantoate reductase: Implications of ligand-induced conformational changes in cofactor recognition. Biochimie (2022). https://doi.org/10.1016/j.biochi.2021.10.015 *Co-first authors

6. Qi C., Lavriha P., Mehta V., Khanppnavar B., Mohammed I., Li Y., Lazaratos M., Schaefer J. V., Dreier B., Plückthun A., Bondar A. N., Dessauer C. W., Korkhov V. M. Structural basis of adenylyl cyclase 9 activation. Nature Communications (2022). https://doi.org/10.1038/s41467-022-28685-y  

5. Khanppnavar B.*, Mehta V*., Qi C*., Korkhov V. Structure and function of adenylyl cyclases, key enzymes in cellular signaling. Current Opinion in Structural Biology (2020). https://doi.org/10.1016/j.sbi.2020.03.003 *Co-first authors

4. Khanppnavar B.*, Roy A.*, Chandra K., Uversky V. N., Maiti N. C., Datta S., Deciphering structural intricacy in virulence effectors for proton-motive force mediated unfolding and Type-III protein secretion. Int. J. Biol. Macromol (2020). https://doi.org/10.1016/j.ijbiomac.2020.04.266 *Co-first authors

3. Khanppnavar B., Chatterjee R., Choudhary G. B., Datta S. Genome-wide survey and crystallographic analysis suggests a role for both horizontal gene transfer and duplication in pantothenate biosynthesis pathways. BBA-General Subjects (2019) https://doi.org/10.1016/j.bbagen.2019.05.017 

2. Khanppnavar B., Datta S. Crystal structure and substrate specificity of ExoY, a unique T3SS mediated secreted nucleotidyl cyclase toxin from Pseudomonas aeruginosa. BBA-General Subjects (2018). https://doi.org/10.1016/j.bbagen.2018.05.021 

1. Khanppnavar B.#, Baruah S., Ray S.K., TALE: an emerging tool for genome editing and genetic  engineering. Current Science (2013).  #Corresponding author https://www.jstor.org/stable/24089850