Molecular Biology and Next Generation Biomaterial Preparation Lab

Welcome to Dr. Niraikulam Ayyadurai's lab website, where we pioneer interdisciplinary studies in biotechnology, biomaterials, and biochemistry. Our focus is on advancing tissue engineering through genetic code expansion and protein engineering. We fabricate nanofibrous scaffolds via electrospinning for wound healing, bone regeneration, and vascular tissue engineering. Additionally, we utilize 3D bioprinting to engineer biomimetic scaffolds, aiming to enhance regenerative capacity. Join us as we address critical challenges in tissue regeneration and therapeutics to revolutionize healthcare and improve global quality of life. 

• Genetic code engineering/expansion for ribosomal translation, synthetic biology of bio-orthogonal chemistries for protein modification and bioconjugation.

• Fabrication of tissue-engineered scaffolds like electrospun nanofibers, hydrogels, and 3D printed constructs using 3D printing technology for regenerative medicine models.

• Biomaterials – Preparing Next-Generation Tailored Materials

The research in this area focuses on developing advanced biomaterials using tools from synthetic biology, protein engineering, and molecular biology. These approaches enable the design and production of high-quality, customizable biomaterials with specific biological and mechanical properties.

A key strategy involves the selective modification and blending of source materials to create specialized formulations such as bioinks for applications in 3D bioprinting and tissue engineering. By precisely tuning the composition and structure of these materials, our group aims to improve biocompatibility, functionality, and performance for biomedical applications.

• Stem Cell Biology

Our research in this area focuses on understanding how stem cells interact with biomaterials and how these interactions regulate cell proliferation, differentiation, and tissue formation.

Studying the cell–material interface is crucial for advancing tissue engineering and regenerative medicine, as biomaterials can influence stem cell behavior through chemical, mechanical, and structural cues. Insights from these studies help in designing optimized scaffolds and biomaterial environments that guide stem cells to develop into desired tissue types.