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Institute of Molecular Biology and Biotechnology, BZU Multan
Syed Aun Muhammad, PhD
Syed Aun Muhammad, PhD
Associate Professor
Associate Professor
Bahaudin Zakariya University, Multan
IMBB Faculty
IMBB Faculty
Dr. Syed Aun Muhammad is serving as Associate Professor at Institute of Molecular Biology and Biotechnology (IMBB), Bahauddin Zakariya University Multan, Pakistan. He graduated with honors from Quaid-e-Azam University, Islamabad and got his degree in the field of Pharmaceutical and Health Biotechnology. In his lab, he is supervising M.Phil. and PhD students actively involved in Health/Pharmaceutical and Medical Biotechnology.
His major research interests include Drug Designing, Vaccine Designing, Genetic investigation of type 2 diabetes mellitus and Cancer, and Systems Biology approaches. Dr. Aun has won a number of research grants and research projects for execution of his research. He has published more than 100 research articles in renowned indexed journals with approximate impact factor of 160. During his study, he visited the Indiana University-Purdue University Indianapolis (IUPUI), Indiana USA and worked on different aspects of computational biology and personalized medicine at Indiana Center for Systems Biology and Personalized Medicine. He completed his professional training from Institute of Biopharmaceutical Engineering and Technologies, Wenzhou Medical University, China.
Research Interests
Drug and Vaccines Designing and Development; Genetic Diseases
Contact Information
Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University 60800, Bosan Road, Multan, Pakistan
Office: 002(61)92100463
Fax: 0092(61)9210069
Email: draun@bzu.edu.pk
Selected Publications
1. Waseem Raza, Jinlei Guo, Muhammad Imran Qadir, Baogang Bai, Syed Aun Muhammad, 2022. qPCR Analysis Reveals Association of Differential Expression of SRR, NFKB1 and PDE4B Genes with Type 2 Diabetes Mellitus. Frontiers in Endocrinology. 12:774696.
2. Fawad Ali, Arifullah Khan, Syed Aun Muhammad, Syed Shams ul Hassan, 2022. Quantitative Real-Time Analysis of Differential Expressed Genes in Peripheral Blood Samples of Hypertension Patients. Genes, 13:87. /doi.org/10.3390/genes13020187
3. Sidra Zafar, Baogang Bai, Jinlei Guo, Syed Aun Muhammad, Syeda Tahira Qousain Naqvi, Muhammad Nauman Shabbir, Imran Imran, Rehan Sadiq Shaikh, Amjad Ali, 2022. Experimental Study of Potential CD8+ Trivalent Synthetic Peptides for Liver Cancer Vaccine Development Using Sprague Dawley Rat Models. BioMed Research International. 2022: 1-18.
4. Hina Tariq, Muhammad Rafi, Muhammad Imran Amirzada, Syed Aun Muhammad, Muhammad Arfat Yameen, Abdul Mannan, Tariq Ismail, Irum Shahzadi, Ghulam Murtaza, Nighat Fatima, 2022. Photodynamic Cytotoxic and Antibacterial Evaluation of Tecoma stans and Narcissus tazetta Mediated Silver Nanoparticles. Arabian Journal of Chemistry.15:103652.
5. Reem Altaf, Humaira Nadeem, Muhammad Nasir Iqbal, Umair Ilyas, Zaman Ashraf, Muhammad Imran, Syed Aun Muhammad, 2022. Synthesis, biological evaluation, 2D-QSAR, and molecular simulation studies of dihydropyrimidinone derivatives as alkaline phosphatase inhibitors. ACS Omega. 10.1021/acsomega.1c06833
6. Umair Ilyas, Shagufta Naaz, Syed Aun Muhammad, Humaira Nadeem, Reem Altaf, Shahiq Uz Zaman, Muhammad Faheem, Fawad Shah, 2022. Cytotoxic Evaluation and Molecular Docking studies of Aminopyridine derivatives as Potential Anticancer Agents. Anti-Cancer Agents in Medicinal Chemistry. doi: 10.2174/1871520622666211228105556.
7. Syed Aun Muhammad, Syeda Tahira Qousain Naqvi, Thanh Nguyen, Xiaogang Wu, Fahad Munir, Muhammad Babar Jamshed, QiYu Zhang, 2021. Cisplatin’s Potential for Type 2 Diabetes Repositioning by Inhibiting CDKN1A, FAS, and SESN1. Computers in Biology and Medicine. 135: 104640.
8. Syeda Tahira Qousain Naqvi, Mamoona Yasmeen, Mehreen Ismail, Syed Aun Muhammad, Syed Nawazish-i-Husain, Amjad Ali, Fahad Munir, Qi-Yu Zhang, 2021. Designing of Potential Polyvalent Vaccine Model for Respiratory Syncytial Virus by System Level Immunoinformatics Approaches. BioMed Research International. 18: 2021. https://doi.org/10.1155/2021/9940010.
9. Reem Altaf, Humaira Nadeem, Mustafeez Mujtaba Babar, Umair Ilyas & Syed Aun Muhammad, 2021. Genome-scale meta-analysis of breast cancer datasets identifies promising targets for drug development. Journal of Biological Research-Thessaloniki. 28:5.
10. Asma Bukhari, Humaira Nadeem, Muhammad Imran, Syed Aun Muhammad. Novel oxadiazole derivatives as potent inhibitors of α-amylase and α-glucosidase enzymes: Synthesis, in vitro evaluation, and molecular docking studies. Iranian Journal of Basic Medical Sciences. 10.22038/IJBMS.2021.58429.12977.
11. Syeda Zahra Abbas, Muhammad Imran Qadir, and Syed Aun Muhammad, 2020. Systems-Level Differential Gene Expression Analysis Reveals New Genetic Variants of Oral Cancer. Nature Scientific Reports. 10, 14667. doi.org/10.1038/s41598-020-71346-7.
12. Syed Aun Muhammad, Sidra Zafar, Samana Rizvi, Imran Imran, Fahad Munir, Muhammad Baber Jamshed, Amjad Ali, Xiaogang wu, Numan Shahid, Muhammad Zaeem, and Qiyu Zhang, 2020. Experimental Analysis of T-Cell Epitopes for Designing Liver Cancer Vaccine Predicted by System Level Immunoinformatics Approach. American Journal of Physiology-Gastrointestinal and Liver Physiology. 1:318(6): G1055-G1069. doi.org/10.1152/ajpgi.00068.2020.
13. Syed Aun Muhammad, Hiba Ashfaq, Sidra Zafar, Fahad Munir, Muhammad Babar Jamshed, Jake Chen, QiYu Zhang, 2020. Polyvalent Therapeutic Vaccine for Type 2 Diabetes Mellitus: Immunoinformatics Approach to Study Co-Stimulation of Cytokines and GLUT1 Receptors. BMC Molecular and Cell Biology. 21:56. doi:10.1186/s12860-020-00279-w.
14. Ehsan Mughal, Jamshaid Ashraf, Amina Sadiq, Nafeesa Naeem, Syed Aun Muhammad, Tahira Qousain, Muhammad N Zafar, Bilal A Khan, Muhammad Anees, 2020. Design and Synthesis of New Flavonols as Dual ɑ-Amylase and ɑ-Glucosidase Inhibitors: Structure-Activity Relationship, Drug-likeness, In vitro and in silico Studies. Journal of Molecular Structure. 1218:128458. doi.org/10.1016/j.molstruc.2020.128458.
15. Hamza Arshad Dar, Tahreem Zaheer, Muhammad Shehroz, Nimat Ullah, Kanwal Naz, Syed Aun Muhammad, Tianyu Zhang and Amjad Ali, 2019. Immunoinformatics-Aided Design and Evaluation of a Potential Multi-Epitope Vaccine against Klebsiella Pneumoniae. Vaccines, 7: 88; doi:10.3390/vaccines7030088.
16. Muhammad Babar Jamshed, Fahad Munir, Numan Shahid, Ussama Sadiq, Syed Aun Muhammad, Noor Bader Ghanem, Hong Zhong, QiYu Zhang, 2019. Antitumor Activity and Combined Inhibitory Effect of Ceritinib with Gemcitabine in Pancreatic Cancer. American Journal of Physiology-Gastrointestinal and Liver Physiology. 318(1): G109-G119. doi.org/10.1152/ajpgi.00130.2019.
17. Syed Aun Muhammad, Nighat Fatima, Rehan Zafar Paracha, Amjad Ali, Jake Y. Chen, 2019. A systematic simulation-based meta-analytical framework for prediction of physiological biomarkers in Alopecia. Journal of Biological Research-BMC. 26:2-16.
18. Fahad Munir, Muhammad Jamshed, Numan Shahid, Syed Aun Muhammad, Adheesh Bhandari, and Zhang Qiyu, 2019. Protective effects of maresin 1 against inflammation in experimentally induced acute pancreatitis and related lung injury. American Journal of Physiology-Gastrointestinal and Liver Physiology. 1;317(3): G333-G341. doi: 10.1152/ajpgi.00078.2019.
19. Muhammad Sohail Arshad, Sameen Fatima, Kazem Nazari, Radeyah Ali, Muhammad Farhan, Syed Aun Muhammad, Nasir Abbas, Amjad Hussain, Israfil Kucuk, Ming-Wei Chang, Prina Mehta & Zeeshan Ahmad, 2019. Engineering and Characterization of BCG-loaded polymeric microneedles. Journal of Drug Targeting. 28(5):525-532. doi.org/10.1080/1061186X.2019.1693577.
20. Huma Tariq, Muhammad Zia, Ihsan-ul-Haq, Syed Aun Muhammad, Shujaat Ali Khan, Nighat Fatima, Abdul Mannan, Arshad Mehmood Abbasi, and Mingxing Zhang, 2019. Antioxidant, Antimicrobial, Cytotoxic, and Protein Kinase Inhibition Potential in Aloe vera L. BioMed Research International. 6478187.
21. Thanh M. Nguyen, Syed Aun Muhammad, Jinlei Guo, Sara Ibrahim, Lin Ma, Baogang Bai, Bixin Zeng, 2018. DeCoSTT: A New Approach in Drug Repurposing from Control System Theory. Frontiers in Pharmacology. 9:583. doi: 10.3389/fphar.2018.00583.
22. Syed Aun Muhammad, Guo J, Nguyen TM, Wu X, Bai B, Yang XF and Chen JY, 2018. Simulation Study of cDNA Dataset to Investigate Possible Association of Differentially Expressed Genes of Human THP1-Monocytic Cells in Cancer Progression Affected by Bacterial Shiga Toxins. Frontiers in Microbiology 9:380.
23. Syed Aun Muhammad, Waseem Raza, Thanh Nguyen, Baogang Bai, Xiaogang Wu and Jake Chen, 2017. Cellular signaling pathways in insulin resistance-Systems biology analyses of microarray dataset reveals new drug target gene signatures of type 2 diabetes mellitus. Frontiers in Physiology. 8:13. doi: 10.3389/fphys.2017.00013.
24. Sidra Rehman, Bushra Ijaz, Nighat Fatima, Syed Aun Muhammad, Sheikh Riazuddin, 2016. Therapeutic potential of Taraxacum officinale against HCV NS5B polymerase: In-vitro and In silico study. Biomedicine and Pharmacotherapy, 83: 881–891.
25. Afreenish Hassan, Anam Naz, Ayesha Obaid, Rehan Zafar Paracha, Kanwal Naz, Faryal Mehwish Awan, Syed Aun Muhammad, Hussnain Ahmed Janjua, Jamil Ahmad, Amjad Ali, 2016. Pangenome and immuno-proteomics analysis of Acinetobacter baumannii strains revealed the core peptide vaccine targets. BMC Genomics, 17:732.
26. Raees MA, Hussain H, Al-Rawahi A, Csuk R, Muhammad SA, Khan HY, Rehman NUr, Abbas G, Al-Broumi MA, Green IR, Elyassi A, Mahmood T, Al-Harrasi A, 2016. Anti-proliferative and computational studies of two new pregnane glycosides from Desmidorchis flava. Bioorganic Chemistry, 67: 95–104.
27. Syed Aun Muhammad, Safia Ahmed, 2015. Production and characterization of a new antibacterial peptide obtained from Aeribacillus pallidus SAT4. Biotechnology Reports. 8:72–80.
28. Syed Aun Muhammad, Nighat Fatima, Nawazish-i-Husain Syed, Xiaogang Wu, X. Frank Yang, Jake Y. Chen, 2015. MicroRNA Expression Profiling of Human Respiratory Epithelium Affected by Invasive Candida infection. PLOS ONE. 10(8): E0136454.
29. Anam Naz, Syed Aun Muhammad, Amjad Ali, 2015. Identification of putative vaccine candidates against Helicobacter pylori exploiting exoproteome and secretome: A reverse vaccinology-based approach. Infection, Genetics and Evolution. 32:280–291.
30. Syed Aun Muhammad and Nighat Fatima, 2015. In silico analysis and molecular docking studies of potential Angiotensin Converting Enzyme (ACE) inhibitor using quercetin glycosides. Pharmacognosy Magazine. 11(42): S123-S126.
31. Syed Aun Muhammad, Safia Ahmed, Amjad Ali, Hui Huang, Xiaogang Wu, X. Frank Yang, Anam Naz, Jake Chen, 2014. Prioritizing Drug Targets in Clostridium botulinum with a Computational Systems Biology Approach. Genomics. 104(1): 24-35.
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Questions?
Contact [draun@bzu.edu.pk] to get more information about the research activities
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