Publications

ATWOOD LAB RESEARCH PUBLICATIONS

Munoz B, Atwood BK. Alcohol consumption does not impact delta and kappa opioid receptor-mediated synaptic depression in dorsolateral striatum of adult male mice. Alcohol. (2024). PMID: 38857678

Duffus B-L, Haggerty DL, Doud E, Mosely A, Yamamoto B, Atwood BK. The impact of withdrawal from chronic alcohol consumption on the mouse striatal proteome: sex and subregion-specific differences. Frontiers in Pharmacology. 3:15:1405446 (2024). PMID: 38887549

Haggerty DL, Atwood BK. Sex-dependent engagement of anterior insular cortex inputs to the dorsolateral striatum in binge alcohol drinking. eLife. PMID: 39196613

Muñoz B, Atwood BK. A novel inhibitory corticostriatal circuit that expresses mu opioid receptor-mediated synaptic plasticity. Neuropharmacology. 240:109696 (2023). PMID: 37659438

Shahid S, Grecco GG, Atwood BK, Wu Y-C. Perturbed neurochemical and microstructural organization in a mouse model of prenatal opioid exposure: a multi-modal magnetic resonance study. PLoS ONE. 18(7):e0282756. (2023). PMID: 37471385

Haggerty DL, Grecco GG, Huang JY, Doud EH, Moseley AL, Lu H-C, Atwood BK. Prenatal methadone exposure selectively alters protein expression in primary motor cortex: implications for synaptic function. Frontiers in Pharmacology. 14:1124108 (2023). PMID: 36817148.

Grecco GG, Shahid S, Atwood BK, Wu Y-C. Alterations of Brain Microstructures in a Mouse Model of Prenatal Opioid Exposure Detected by Diffusion MRI. Scientific Reports. 12(1):17085 (2022). PMID: 36224335

Muñoz B, Fritz BM, Yin F, Atwood BK.  HCN1 channels mediate mu opioid receptor long-term depression at insular cortex inputs to the dorsal striatum. Journal of Physiology. 600(22):4917-4938 (2022). PMID: 36181477

Haggerty DL, Muñoz B, Pennington T, Grecco GG, Fritz BM, Atwood BK. Anterior insular cortex inputs to the dorsolateral striatum govern the maintenance of binge alcohol drinking. eLife. 11:e77411 (2022). PMID: 36098397

Grecco GG, Huang JY, Muñoz B, Doud EH, Hines CD, Gao Y, Rodriguez B, Moseley AL, Lu H-C, Atwood BK. Sex-Dependent Synaptic Remodeling of the Somatosensory Cortex in Mice With Prenatal Methadone Exposure. Advances in Drug and Alcohol Research. doi.org/10.3389/adar.2022.10400 (2022).

Grecco GG, Munoz B, Viana Di Prisco G, Doud EH, Fritz BM, Maulucci D, Gao Y, Moseley AL, Baucum AJ, Atwood BK. Prenatal opioid exposure impairs endocannabinoid and glutamate transmission in the dorsal striatum. eNeuro. 9(2):ENEURO.0119-22.2022 (2022). PMID: 35396255

Grecco GG, Haggerty DL, Reeves KC, Gao Y, Maulucci D, Atwood BK. Prenatal Opioid Exposure Reprograms the Behavioral Response to Future Alcohol Reward. Addiction Biology. 27(2):e13136 (2022). PMID: 35229956

Grecco GG, Gao Y, Gao H, Liu Y, Atwood BK. Prenatal Opioid Administration Induces Shared Alterations to the Maternal and Offspring Gut Microbiome. Drug and Alcohol Dependence. 227:108914 (2021). PMID: 34364194

Grecco GG, Mork B, Huang JY, Metzger CE, Haggerty DL, Reeves KC, Gao Y, Hoffman H, Katner SN, Masters AR, Morris CW, Newell EA, Baucum, AJ Engleman EA, Kim J, Yamamoto BK, Allen MR, Wu YC, Lu HC, Sheets PL, Atwood BK. Prenatal Methadone Exposure Disrupts Behavioral Development and Alters Motor Neuron Intrinsic Properties and Local Circuitry. eLife. 10:e66230 (2021). PMID: 33724184.

Fritz BM, Yin F, Atwood BK. Input-Selective Adenosine A1 Receptor-Mediated Synaptic Depression of Excitatory Transmission in Dorsal Striatum. Scientific Reports. 11(1):6345 (2021). PMID: 33737568

Grecco GG, Haggerty DL, Doud E, Fritz BM, Hoffman H, Mosely A, Simpson E, Liu Y, Baucum AJ, Atwood BK. A Multi-Omic Analysis of the Dorsal Striatum in an Animal Model of Divergent Genetic Risk for Alcohol Use Disorder. J. Neurochem. 157(4):1013-1031. (2021). PMID: 33111353

Reeves KC, Kube MJ, Grecco GG, Fritz BM, Muñoz B, Yin F, Gao Y, Haggerty DL, Hoffman HJ, Atwood BK. Mu opioid receptors on vGluT2-expressing glutamatergic neurons modulate opioid reward. Addiction Biology. Jul 20:e12942 (2020). PMID: 32686251

Muñoz B, Haggerty DL, Atwood BK. Synapse-specific expression of mu opioid receptor long-term depression in the dorsomedial striatum. Scientific Reports. 10(1):7234 (2020). PMID: 32350330

Fritz BM, Muñoz B, Atwood BK. Genetic Selection for Alcohol Preference in Mice Alters Dorsal Striatum Neurotransmission. Alcoholism: Clinical and Experimental Research. 43 (11):2312-2321 (2019). PMID: 31491046.

Muñoz B, Fritz BM, Yin F, Atwood BK.  Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum. Nature Communications. 9(1):1318 (2018). PMID: 29615610.

Fritz BM, Muñoz, B, Yin F, Bauchle C, Atwood BK. A high-fat, high-sugar 'western' diet alters dorsal striatal glutamate, opioid, and dopamine transmission in mice. Neuroscience. 372:1-15 (2018). PMID: 29289718.

Atwood BK, Kupferschmidt DA, Lovinger DM. Opioids induce dissociable forms of long-term depression of excitatory inputs to the dorsal striatum. Nature Neuroscience. 17(4): 540-548 (2014). PMID: 24561996

Atwood BK, Straiker A, Mackie K. CB(2) cannabinoid receptors inhibit synaptic transmission when expressed in cultured autaptic neurons. Neuropharmacology. 63(4): 514-523 (2012). PMID: 22579668 

Atwood BK, Wager-Miller J, Haskins C, Straiker A, Mackie K. Functional selectivity in CB(2) cannabinoid receptor signaling and regulation: implications for the therapeutic potential of CB(2) ligands. Molecular Pharmacology. 81(2): 250-263 (2012). PMID: 22064678

Atwood BK, Lee D, Straiker A, Widlanski TS, Mackie K. CP47,497-C8 and JWH073, commonly found in 'Spice' herbal blends, are potent and efficacious CB(1) cannabinoid receptor agonists. European Journal of Pharmacology. 659(2-3): 139-145 (2011). PMID: 21333643

Atwood BK, Huffman J, Straiker A, Mackie K. JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB receptor agonist. British Journal of Pharmacology. 160(3): 585-593 (2010). PMID: 20100276

COLLABORATIVE RESEARCH PUBLICATIONS

Metzger C, Grecco GG, Tak LY, Atwood BK, Allen MR. Two weeks of continuous opioid treatment in an adenine-induced mouse model of chronic kidney disease exacerbates the bone inflammatory state and increases osteoclasts. Calcified Tissue International. (2024). PMID: 38856730

Yin Y, Haggerty DL, Zhou S, Atwood BK, Sheets PL. Converging Effects of Chronic Pain and Binge Alcohol Consumption on Anterior Insular Cortex Neurons Projecting to the Dorsolateral Striatum. Journal of Neuroscience. 44(16):e1287232024 (2024). PMID: 38453466

Chhabra KH, Bathina S, Faniyan TS, Samuel DJ, Raza MU, Maria de Souza Cordeiro L, Viana Di Prisco G, Atwood BK, Robles J, Bainbridge L, Davis A. ADGRL1 is a glucose binding receptor involved in energy and glucose homeostasis. Diabetologia. 67(1):170-189 (2024). PMID: 37712955

Tsai AP, Dong C, Lin PB-C, Oblak AL, Viana Di Prisco G, Wang N, Hajicek N, Carr A, Lendy EK, Hahn O, Atkins ME, Foltz AG, Patel J, Xu G, Moutinho M, Sondek J, Zhang Q, Mesecar AD, Liu Y, Atwood BK, Wyss-Coray T, Nho K, Bissel SJ, Lamb BT, Landreth GE. Genetic Variants of Phospholipase Cγ2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimer’s disease. Immunity. Immunity. S1074-7613(23)00364-3. (2023). PMID: 37659412

Shahid S, Grecco GG, Atwood BK, Wu Y-C. Perturbed neurochemical and microstructural organization in a mouse model of prenatal opioid exposure: a multi-modal magnetic resonance study. PLoS ONE. 18(7):e0282756. (2023). PMID: 37471385

Moutinho M, Coronel I, Tsai AP, Viana Di Prisco G, Pennington T, Atwood BK, Puntambekar SS, Smith DC, Martinez P, Han S, Lee Y, Lasagna-Reeves CA, Lamb BT, Bissel SJ, Nho K, Landreth GE. TREM2 splice isoforms increase in Alzheimer’s disease and generate soluble TREM2 which disrupts long-term potentiation. Genome Medicine. 15(1):11. (2023). PMID: 36805764

Morris CW, Watkins DS, Pennington T, Doud E, Qi G, Mosley A, Atwood BK, Baucum AJ. Spinophilin limits metabotropic glutamate receptor 5 scaffolding to the postsynaptic density and mediates excessive grooming cell type-specifically. Biological Psychiatry. 93(11):976-988. (2023). PMID: 36822932

El Jordi O, Fischer KD, Meyer TB, Atwood BK, Oblak AL, Pan RW, McKinzie DL. Microglial knockdown does not affect acute withdrawal but delays analgesic tolerance from oxycodone in male and female C57BL/6J mice. Advances in Drug and Alcohol Research. In press. doi: 10.3389/adar.2022.10848

Martinez P, Patel H, You Y, Jury N, Perkins A, Lee-Gosselin A, Taylor X, You Y, Viana Di Prisco G, Huang X, Dutta S, Wijeratne A, Redding-Ochoa J, Shahid SS, Codocedo JF, Min S, Landreth GE, Mosley AL, Wu Y-C, McKinzie D, Rochet C, Zhang J, Atwood BK, Troncoso J, Lasagna-Reeves CA. Bassoon contributes to tau-seed neurotoxicity and propagation. Nature Neuroscience. 25(12):1597-1607 (2022). PMID: 36344699 

Karahan H, Smith D, Kim B, El-Amin MM, Dabin L, Pennington T, Viana di Prisco G, McCord B, Lin P, Atwood BK, Oblak A, Kim J. Deletion of Abi3 gene exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosis. Science Advances. 7(45):eabe3954 (2021). PMID: 34731000

Kramer NB, Ross RA, Fenselau H, DQ, Haggerty DL, Atwood B, Lowell B, Flak JN. The Role of Ventromedial Hypothalamic PACAP in the Control of Body Weight and Metabolism. Endocrinology. 162(4):bqab012 (2021). PMID: 33460433

Jadhav VS, Lin PB, Xu G, Pennington T, Viana Di Prisco G, Jacob A, Moutinho M, Puntambekar SS, Zhang J, Atwood BK, Bissel SJ, Oblak AL, Landreth GE, Lamb BT. Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses with age. Molecular Neurodegeneration. 15(1):62 (2020). PMID: 33115519

isternas P, Taylor X, Perkins A, Maldonado O, Allman E, Cordova R, Marambio Y, Munoz B, Pennington T, Xiang S, Zhang J, Vidal R, Atwood B, Lasagna-Reeves CA. Vascular amyloid accumulation alters the gabaergic synapse and induces hyperactivity in a model of cerebral amyloid angiopathy. Aging Cell. (2020). 19(10):e13233. PMID: 32914559

Mulcahy G , Atwood B, Kuznetsov A. Basal Ganglia role in learning reward actions and executing previously learned choices: healthy and diseased states. PLOS ONE. 15(2):e0228081 (2020). PMID: 32040519

Jay T, von Saucken VE, Muñoz B, Codocedo JF, Atwood BK, Lamb BT, Landreth GE. The neurodegeneration-associated receptor TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment. Glia. 67(10):1873-1892 (2019). PMID: 31265185.

You Y, Perkins A, Cisternas P, Muñoz B, Taylor X, You Y, Garringer HJ, Oblak AL, Ghetti B, Atwood BK, Vidal R, Lasagna-Reeves C. Tau as a mediator of neurotoxicity associated to Cerebral Amyloid Angiopathy. Acta Neuropathologica Communications. 7(1):26 (2019). PMID: 30808415.

Mateo Y, Johnson K, Covery DP, Atwood BK, Wang HL, Zhang S, Gildish I, Cachope R, Bellocchio L, Guzman M, Morales M, Cheer J, Lovinger DM. Endocannabinoid Actions on Cortical Terminals Orchestrate Local Modulation of Dopamine Release in the Nucleus Accumbens. Neuron, 96(5):1112-1126 (2017). PMID: 29216450

Gremel C, Chancey J, Atwood BK, Luo G, Neve R, Ramakrishnan C, Deisseroth K, Lovinger DM, Costa R. Endocannabinoid modulation of orbitostriatal circuits gates habit formation. Neuron. 90(6):1312-1324 (2016). PMID: 27238866

REVIEW PUBLICATIONS

Simmons SC, Grecco GG, Atwood BK, Nugent FS. Effects of Prenatal Opioid Exposure on Synaptic Plasticity and Behaviors Across Development. Neuropharmacology. 222:109312 (2022). PMID: 36334764

Reeves KC, Shah N, Muñoz B, Atwood BK. Opioid receptor-mediated regulation of neurotransmission in the brain. Frontiers in Molecular Neuroscience. 15:919773 (2022). PMID: 35782382

Centanni S, Janes AC, Haggerty DL, Atwood BK, Hopf FW. Better living through understanding the insula: why subregions can make all the difference. Neuropharmacology. 198:108765 (2021). PMID: 34461066

Grecco GG, Atwood BK. Prenatal Opioid Exposure Enhances Responsiveness to Future Drug Reward and Alters Sensitivity to Pain: A Review of Preclinical Models and Contributing Mechanisms. eNeuro. ENEURO.0393-20.2020 (2020) PMID: 33060181

Radhakrishnan R, Grecco G, Stolze K, Atwood BK, Jennings SG, Lien IZ, Saykin AJ, Sadhasivam S. Early Neuroimaging in Infants with Prenatal Opioid Exposure: Insights and Recent Developments. Journal of Neuroradiology. 13:S0150-9861(20)30278-9 (2020). PMID: 33065196

Haggerty DL, Grecco GG, Reeves K, Atwood B. Adeno-associated viral vectors in neuroscience research. Molecular Therapy - Methods and Clinical Development. 17:69-82 (2019). PMID: 31890742

Atwood BK, Lovinger DM. Endocannabinoid-dependent synaptic plasticity in striatum. Endocannabinoids and Lipid Mediators in Brain Functions. 109-153 (2017).

Atwood BK, Lovinger DM, Mathur BM. Presynaptic long-term depression mediated by Gi/o-coupled receptors. Trends in Neurosciences. 37(11): 663-673 (2014). PMID: 25160683

Contribution: Participated in writing manuscript. Created figures.

Atwood BK, Straiker A, Mackie K. CB(2): Therapeutic target-in-waiting. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 38(1): 16-20 (2012). PMID: 22197668

Atwood BK, Mackie K. CB2: a cannabinoid receptor with an identity crisis. British Journal of Pharmacology. 160(3): 467-479 (2010). PMID: 20590558