Embedded Files
15. “Reducing complexity in lipid nanoparticles: Three-component zwitterionic amino lipids for targeted extrahepatic mRNA delivery.” Joshua J. Robinson, Di Zhang, Pratima Basak, Amogh Vaidya, Sumanta Chatterjee, Xiaoyan Bian, Minjeong Kim, Xizhen Lian, Yehui Sun, Erick Guerrero, Xu Wang, Sang M. Lee, Shuai Liu, Junyu Gong, Mayank Tiwari, Godwin K. Babanyinah, Mihaela C. Stefan, Lukas Farbiak, and Daniel J. Siegwart* ACS Biomaterials Science & Engineering, 11, 4853-4868 (2025).
14. "Dual SORT LNPs for multi-organ base editing" Minjeong Kim, Eunice S. Song, Joseph C. Chen, Sumanta Chatterjee, Yehui Sun, Sang M. Lee, Shiying Wu, Priyanka Patel, Zeru Tian, Ariel Kantor, Brandon A. Wustman, David J. Lockhart & Daniel J. Siegwart* Nature Biotechnology, (2025). 10.1038/s41587-025-02675-z
Nature Biotechnology Research Briefing highlight article entitled "Delivering base editors to the liver and lungs in alpha-1 antitrypsin deficiency" Nat. Biotechnol. (2025). https://doi.org/10.1038/s41587-025-02705-w
The Dallas Morning News article entitled "Rescued by fat bubbles: UTSW scientists treat rare genetic disease with designer molecule" Jul. 10, 2025
13. “Isosteric 3D bicyclo[1.1.1]pentane (BCP) core-based lipids for mRNA delivery and CRISPR/Cas gene editing.” Shiying Wu, Yangyang Yang, Xizhen Lian, Fangyu Zhang, Chao Hu, Jet Tsien, Zexiang Chen, Yehui Sun, Amogh Vaidya, Minjeong Kim, Yun-Chieh Sung, Yufen Xiao, Xiaoyan Bian, Xu Wang, Zeru Tian, Erick Guerrero, Joshua Robinson, Pratima Basak, Tian Qin,* and Daniel J. Siegwart.* Journal of the American Chemical Society, 146, 34733-34742 (2024).
12. “In vivo editing of lung stem cells for durable gene correction in mice.” Yehui Sun#, Sumanta Chatterjee#, Xizhen Lian, Zachary Traylor, Sandhya R. Sattiraju, Yufen Xiao, Sean A. Dilliard, Yun-Chieh Sung, Minjeong Kim, Sang M. Lee, Stephen Moore, Xu Wang, Di Zhang, Shiying Wu, Pratima Basak, Jialu Wang, Jing Liu, Rachel J. Mann, David F. LePage, Weihong Jiang, Shadaan Abid, Mirko Hennig, Anna Martinez, Brandon A. Wustman, David J. Lockhart, Raksha Jain, Ronald A. Conlon, Mitchell L. Drumm, Craig A. Hodges, and Daniel J. Siegwart.* Science, 384, 1196 (2024).
11. “Spleen SORT LNP generated in situ CAR T cells extend survival in a mouse model of lymphoreplete B cell lymphoma.” Ester Álvarez-Benedicto, Zeru Tian, Sumanta Chatterjee, Domenico Orlando, Minjeong Kim, Erick D. Guerrero, Xu Wang, Daniel J. Siegwart.* Angewandte Chemie International Edition, 62, e202310395 (2023).
10. "In vivo genome editing for hemophilia B therapy by the combination of rebalancing and therapeutic gene knockin using a viral and non-viral vector" Jeong Hyeon Lee, Jeong Pil Han, Dong Woo Song, Geon Seong Lee, Beom Seok Choi, MinJeong Kim, Yeji Lee, Seokjoong Kim, Hyukjin Lee, Su Cheong Yeom* Molecular Therapy Nucleic Acids, 21, 161-172 (2023).
9. "Novel piperazine-based ionizable lipid nanoparticles allow the repeated dose of mRNA to fibrotic lungs with improved potency and safety" Minjeong Kim#, Michaela Jeong#, Gyeongseok Lee, Yeji Lee, Jeongeun Park, Hyein Jung, Seongeun Im, Joo-Sung Yang, Kyungjin Kim, Hyukjin Lee * Bioengineering Translational Medicine, 8, e10556 (2023).
8. "Engineered Lipid Nanoparticles for the Treatment of Pulmonary Fibrosis by Regulating Epithelial-Mesenchymal Transition in the Lungs" Hee Jin#, Michaela Jeong#, Gyeongseok Lee, Minjeong Kim, Youngjo Yoo, Hyun Jin Kim, Jaeho Cho, Yun-Sil Lee, Hyukjin Lee. Advanced Functional Materials, 23, 2209432 (2022).
7. "Protein-RNA interaction guided chemical modification of Dicer substrate RNA nanostructures for superior in vivo gene silencing" Bora Jang, Hyejin Jang, Hyunsook Kim, Minjeong Kim, Michaela Jeong, Gyeong Seok Lee, Kyuri Lee, Hyukjin Lee, Journal of Controlled Release, 343, 57-65 (2022).
6. "In vivo delivery of CRISPR-Cas9 using lipid nanoparticles enables antithrombin gene editing for sustainable hemophilia A and B therapy" Jeong Pil Han#, MinJeong Kim#, Beom Seok Choi#, Jeong Hyeon Lee, Geon Seong Lee, Michaela Jeong, Yeji Lee, Eun-Ah Kim, Hye-Kyung Oh, Nanyeong Go, Hyerim Lee, Kyu Jun Lee, Un Gi Kim, Jae Young Lee, Seokjoong Kim, Jun Chang, Hyukjin Lee*, Dong Woo Song*, and Su Cheong Yeom* Science Advances, 8, abj6901 (2022).
5. "Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver" Minjeong Kim#, Michaela Jeong, S. Hur, Y. Cho, J. Park, H. Jung, Y. Seo, H. A. Woo, K. T. Nam, K. Lee, Hyukjin Lee* Science Advances, 7, abf4398 (2021).
4. "Nanoformulated Single-Stranded RNA-Based Adjuvant with a Coordinative Amphiphile as an Effective Stabilizer: Inducing Humoral Immune Response by Activation of Antigen-Presenting Cells" Hyo-Jung Park, Eun-Kyoung Bang, Jung Joo Hong, Sang-Myeong Lee, Hae Li Ko, Hye Won Kwak, Hyelim Park, Kyung Won Kang, Rhoon-Ho Kim, Seung Rok Ryu, Green Kim, Hanseul Oh, Hye-Jung Kim, Kyuri Lee, Minjeong Kim, Soo Young Kim, Jae-Ouk Kim, Karim El-Baz, Hyukjin Lee, Manki Song, Dae Gwin Jeong, Gyochang Keum, Jae-Hwan Nam* Angewandte Chemie International Edition 59, 11540 (2020).
3. "Development of mRNA vaccines and their prophylactic and therapeutic applications" Kyuri Lee#, Minjeong Kim#, Yunmi Seo, Hyukjin Lee* Nano Research, 11, 5173–5192 (2018).
2. "Emergence of synthetic mRNA: In vitro synthesis of mRNA and its applications in regenerative medicine" Hyokyoung Kwon#, Minjeong Kim#, Yunmi Seo, Yae Seul Moon, Hwa Jeong Lee, Kyuri Lee, Hyukjin Lee* Biomaterials, 156, 172-193 (2018).
1. "Enzymatic Synthesis of Self-assembled Dicer Substrate RNA Nanostructures for Programmable Gene Silencing" Bora Jang , Boyoung Kim, Hyunsook Kim, Hyokyoung Kwon, Minjeong Kim, Yunmi Seo, Marion Colas, Hansaem Jeong, Eun Hye Jeong, Kyuri Lee, Hyukjin Lee* Nano Letters, 18, 4279-4284 (2018).
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