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My research is broadly focused in developing new catalytic enantioselective/ non enantioselective methods for organo- sulfur compounds synthesis and extending their applications towards polymer functional materials.
My research is broadly focused in developing new catalytic enantioselective/ non enantioselective methods for organo- sulfur compounds synthesis and extending their applications towards polymer functional materials.
Catalytic Enantioselective Organic Synthesis
Catalytic Enantioselective Organic Synthesis
Precision Asymmetric Catalysis: Leveraging transition metal and organocatalysis to develop novel enantioselective transformations.
Precision Asymmetric Catalysis: Leveraging transition metal and organocatalysis to develop novel enantioselective transformations.
Stereocontrolled Reaction Design: Rationally tuning metal coordination geometries (e.g., octahedral vs. pentagonal bipyramidal) to control spatial orientation in the transition state.
Stereocontrolled Reaction Design: Rationally tuning metal coordination geometries (e.g., octahedral vs. pentagonal bipyramidal) to control spatial orientation in the transition state.
Enantiodivergent Synthesis: Utilizing sterically demanding chiral ligands to selectively direct nucleophilic attack (Re-face vs. Si-face attack) for the precise construction of specific stereocenters.
Enantiodivergent Synthesis: Utilizing sterically demanding chiral ligands to selectively direct nucleophilic attack (Re-face vs. Si-face attack) for the precise construction of specific stereocenters.
Organosulfur chemistry
Organosulfur chemistry
My research area is also centered on unlocking the underexplored reactivity of sulfur to develop novel synthetic methodologies and functional materials. We aim to overcome the challenges associated with the chemo- and stereoselective introduction of sulfur functionalities (such as thiols, sulfinamides, sulfonamides, sulfonyl azides, and advanced S(VI) species) into complex molecular architectures. By leveraging precise catalyst design, we can engineer the transition state to achieve high stereochemical control. This approach enables the rational design of powerful synthetic intermediates, allowing us to functionalize diverse common precursors, including carboxylic acids, and aromatic halides, into synthetically valuable organosulfur compounds. These methodologies form a foundational toolkit for applications in medicinal chemistry and total synthesis.
My research area is also centered on unlocking the underexplored reactivity of sulfur to develop novel synthetic methodologies and functional materials. We aim to overcome the challenges associated with the chemo- and stereoselective introduction of sulfur functionalities (such as thiols, sulfinamides, sulfonamides, sulfonyl azides, and advanced S(VI) species) into complex molecular architectures. By leveraging precise catalyst design, we can engineer the transition state to achieve high stereochemical control. This approach enables the rational design of powerful synthetic intermediates, allowing us to functionalize diverse common precursors, including carboxylic acids, and aromatic halides, into synthetically valuable organosulfur compounds. These methodologies form a foundational toolkit for applications in medicinal chemistry and total synthesis.
Photocatalysis
Photocatalysis
My research focuses on developing innovative photocatalytic systems designed for the direct conversion of abundant chemical feedstocks into complex molecules, utilizing organic acridine photocatalysts to mediate direct decarboxylative functionalization transformations. A key aspect of my work involves leveraging photoinduced proton-coupled electron transfer (PCET) mechanisms to enable efficient, one-step alkylations from carboxylic acids. This strategic combination unlocks new reaction pathways for tricomponent coupling reactions and provides access to a wide range of functional groups, significantly streamlining the synthesis of complex molecules from simple starting materials.
My research focuses on developing innovative photocatalytic systems designed for the direct conversion of abundant chemical feedstocks into complex molecules, utilizing organic acridine photocatalysts to mediate direct decarboxylative functionalization transformations. A key aspect of my work involves leveraging photoinduced proton-coupled electron transfer (PCET) mechanisms to enable efficient, one-step alkylations from carboxylic acids. This strategic combination unlocks new reaction pathways for tricomponent coupling reactions and provides access to a wide range of functional groups, significantly streamlining the synthesis of complex molecules from simple starting materials.
Si-polymer / Preceramic polymers (PCP) for high temperature applications
Si-polymer / Preceramic polymers (PCP) for high temperature applications
Apart from small complex molecules design and synthesis, my research also focuses on the foundational design and precision synthesis of silicon-containing pre-ceramic polymers (PCP). These materials are engineered from the polymer stage to possess tailored architectures and functionalities, which are then precisely controlled during their conversion into advanced ceramic materials. Our research addresses critical material challenges in ultra-high-temperature ceramic (UHTC) applications, specifically for aviation.
Apart from small complex molecules design and synthesis, my research also focuses on the foundational design and precision synthesis of silicon-containing pre-ceramic polymers (PCP). These materials are engineered from the polymer stage to possess tailored architectures and functionalities, which are then precisely controlled during their conversion into advanced ceramic materials. Our research addresses critical material challenges in ultra-high-temperature ceramic (UHTC) applications, specifically for aviation.
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