Rationale:  Extracorporeal membrane oxygenation (ECMO) may provide mechanical pulmonary and circulatory support for patients with cardiogenic shock refractory to conventional medical therapy. Prediction of survival in these patients may assist in management of these patients and comparison of results from different centers.

Methods and results:  Patients with refractory cardiogenic shock treated with veno-arterial ECMO between January 2003 and December 2013 were extracted from the international Extracorporeal Life Support Organization registry. Multivariable logistic regression was performed using bootstrapping methodology with internal and external validation to identify factors independently associated with in-hospital survival. Of 3846 patients with cardiogenic shock treated with ECMO, 1601 (42%) patients were alive at hospital discharge. Chronic renal failure, longer duration of ventilation prior to ECMO initiation, pre-ECMO organ failures, pre-ECMO cardiac arrest, congenital heart disease, lower pulse pressure, and lower serum bicarbonate (HCO3) were risk factors associated with mortality. Younger age, lower weight, acute myocarditis, heart transplant, refractory ventricular tachycardia or fibrillation, higher diastolic blood pressure, and lower peak inspiratory pressure were protective. The SAVE-score (area under the receiver operating characteristics [ROC] curve [AUROC] 0.68 [95%CI 0.64-0.71]) was created. External validation of the SAVE-score in an Australian population of 161 patients showed excellent discrimination with AUROC = 0.90 (95%CI 0.85-0.95).


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I lost a 700+ day run to a save issue a few months ago. One minute it would save ,then it wouldn't until it stopped saving altogether. I ended up throwing Astrid off a cliff in HRV. The only time I ever went there in the entire run.

Can I start a new sandbox game and then just transfer all the files from the Survival save directory to the new game directory? Is there some other way to convert my current game from Survival to Sandbox so my changes will not get overwritten?

Because the info about the world is saved in several other files, just modifying the sand.bin would not be enough. And if you try to copy over the other files it can have bad consequences, for example things such as time resetting, crops not growing and so on.

Did you have any success with this idea? I am just starting out with modding Ark (have prog experience in multiple languages, and some minecraft modding etc). So for an idea I have I will need to save data but am having trouble finding out if it is possible with the ark modding kit?

Without thinking when I launched the game, the first thing I did was change the difficulty on one of my main saves to Survival mode. After playing through Survival mode and realizing how tough it was (especially since I hadn't finished exploring the entire Commonwealth), I tried switching back but found no option to do so.

Apparently, from looking online, the changes I make are "final" if I decide to convert a save from normal to Survival. But I made these changes on accident fully unaware of the repercussions of doing so.

You can switch a survival game to a different difficulty the same way you normally change the difficulty, through the Settings -> Gameplay menu. I don't know if this was missing when the beta was released yesterday, but I just tested it by loading a save, switching it to survival, and then switching it back.

Lowering the difficulty from survival is a one-way change, you cannot lower the difficulty and then raise it back to survival, as indicated by the warning you get when you try to lower the difficulty:

Put an inch or two of sand or pebbles in the bottom of a one liter bottle to weigh it down. Fill the rest of the bottle with water and put it in your toilet tank, safely away from the operating mechanism. In an average home, the bottle may save five gallons or more of water every day without harming the efficiency of the toilet. If your tank is big enough, you may even be able to put in two bottles.

Long-term treatment with Captopril started early post myocardial infarction in patients with asymptomatic or minimally symptomatic left ventricular dysfunction improves survival and morbidity due to major cardiovascular events. This benefit of ACE inhibitor is recognized despite treatment with standard agents including beta blockers, thrombolytics and aspirin. Cardiovascular death and/or LV dilatation occurred in >50% of patients by 2 years.

So here's my question: Is it possible to make a copy of this save file and change that copy to creative so I can experiment and plot things out before going back to the original save (in survival) to try and build it for real?

Hybrids, which are created by crossing plants of two different varieties, generally do not produce offspring with the same traits as the parent plant. Seeds saved from open-pollinated varieties, on the other hand, will produce plants identical to the parent. Seed Savers Exchange offers only open-pollinated varieties through its online and print catalog and on The Exchange, its gardener-to-gardener seed swap.

The Seed Garden: The Art and Practice of Seed Saving is filled with advice for the home gardener and the more seasoned horticulturist alike and provides straightforward instructions on how to collect and save seed from your favorite heirloom and open-pollinated plants.

By providing my mobile phone number, I agree to receive recurring text messages from Save the Children (48188) and phone calls with opportunities to donate and ways to engage in our mission to support children around the world. Text STOP to opt-out, HELP for info. Message & data rates may apply. View our Privacy Policy at savethechildren.org/privacy.

The Cincinnati Bengals welcomed fans to learn the lifesaving skill of Hands-Only CPR with the American Heart Association, Cintas and Kettering Health. Bengals Save The Dey presented by Cintas, held Oct. 24 in Paycor Stadium, trained 500 participants to act with confidence and capability in the event of a cardiac emergency at home, work or in the community. With more than 350,000 sudden cardiac arrest emergencies happening outside of the hospital each year, CPR, if performed immediately, could double, or triple a victim's chance of survival. Additionally, select local schools received CPR and AED kits following the event.

"When the world saw Damar Hamlin experience a cardiac arrest on Monday Night Football last season, what they also saw were those very first links in the chain of survival working. Everything happened like it should in a cardiac arrest emergency. This includes, early recognition, calling 911 with responders immediately on the scene, administering high-quality CPR, and having access to, and using an Automated External Defibrillator," says Nancy Brown, CEO of the American Heart Association. "Knowing how to respond in a cardiac emergency when seconds matter is literally the difference between life and death. We are so proud to be a part of Save The Dey to educate and add more lifesavers in the community."

Seed-covered paper towels on counters, windowsills, shelves, tabletops, dressers and even the bathroom counter are common in our house during the fall as we save pumpkin seeds alongside the other heirlooms we want to plant in our spring gardens.

The analysis showed a greater likelihood of survival when a bystander used AED (67%) rather than wait for emergency medical services to shock the heart (43%). In addition, people were more likely to survive with minimal disability after cardiac arrest (57% for AED from a bystander versus 33% for AED initiated by emergency medical services). The more time that elapsed before emergency medical services arrived, the larger the benefit of bystanders using an AED.

A previous analysis of 2005 to 2009 data by the team found that about 500 additional lives could be saved each year in the U.S. and Canada if bystanders used AEDs. Because of increased availability of AEDs and increased use by bystanders, they now estimate that 3,459 people having a cardiac arrest could be saved each year by bystander AED use.

Anna Harleen: Shawn saw his daughter on the ground, dead and then brought back to life through the actions of bystanders and an AED. This harrowing experience informs both the deep gratitude that he has for Bill and the others that rescued Lexi as well as his passionate advocacy for legislation to improve cardiac arrest survival.

Anna Harleen: Sudden cardiac arrest often strikes without warning and it can affect seemingly healthy young people like Lexi. Among the many things that we can learn from Shawn and Bill, remember to make sure that there is always a charged well-maintained AED wherever you go to exercise, work, learn, or play. Anyone can save a life from sudden cardiac arrest. You just need a few very simple skills and tools to respond.

We are proud that 82 cents of every dollar received from donations, research grants, insurance recoveries and investment returns goes to support the current and future needs of St. Jude. Our donors can trust that their giving has helped save the lives of thousands of children.

Curing catastrophic diseases in children is a multi-trillion dollar, multi-year problem and we must continue our work no matter what happens with the economy or in the event of a disaster. The public and our amazing partners make it possible for us to save children together.

Treatments developed at St. Jude have helped push the overall survival rate for childhood cancer from 20% when the hospital opened in 1962 to more than 80% today. In addition, St. Jude has achieved a 94% survival rate for ALL. The survival rate for ALL was only 4% when St. Jude opened in 1962. The survival rate for medulloblastoma, a type of brain tumor, is 85% today for average risk disease.

We thank our donors and encourage their support, which allows us to continue working tirelessly to provide protection, nutrition, education, health, cash and shelter. Our goal is to ensure the survival, learning and protection of every child." 17dc91bb1f

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