2025-cont.
Postdoctoral Researcher
Star-UBB, Cluj-Napoca, Romania
2022-2024
IoE-Postdoctoral Fellow
Indian Institute of Science, Bangalore, India
2017-2022
PhD, Theoretical Medicine/ Computational Biochemistry
HUN REN Biological Research Centre, Szeged, Hungary (University of Szeged, Doctoral School of Theoretical Medicine) (QS 470/2019)
2016-2017
International Training Fellow (ITC)
HUN REN Biological Research Centre, Szeged, Hungary
2015 (6 months)
UPE II Research associate
University of Hyderabad, Hyderabad, India
2013-2015
MSc, Molecular Microbiology with 8.3 CGPA (1st division with distinction)
University of Hyderabad, Hyderabad, India
2010-2013
BSc, Microbiology with 78% (1st class)
Ramakrishna Mission Vidyamandira (University of Calcutta), Belur Math, India
2010
Class (X+II), 83% with (1st division with A+ Grade)
West Bengal Council of Higher Secondary Education
2008
Class X, 89.25% with (1st division with Star)
West Bengal Board of Secondary Education
2025 – cont.: Nucleosome Dynamics and role of transcription factors
Coming Soon...
2022 – 2024: Spatiotemporal organization of lipids in the human plasma membrane
A special type of protein, called actin, forms long polymeric filaments that organize near the membrane through the collective efforts of molecular motor proteins that consume ATP to drive the actin filaments out of equilibrium. This self-organized structure is called the cortical actin cytoskeleton (ACS), which interacts with the membrane and drives it out of equilibrium. Based on these the specific projects are:
Self-diffusion on active membrane breaks fluctuation-dissipation theorem.
Tube-like nanomaterial non-equilibrium pulling along the bilayer perturbs the viscosity of the membrane.
2017 - 2022: Structural Mechanism of Activation of G Protein-Coupled Receptors
The focus of this investigation was the structural mechanism of activation of G protein-coupled receptors (GPCRs) in their native environment, which led to a novel hypothesis about the activation mechanism of GPCRs. The initiation step of GPCR activation is the shift of macroscopic polarization in the transmembrane domain, furnished by the concerted reorganization of conserved polar species.
Other projects related to the prediction of small molecule or ligand binding sites are:
Rapamycin and analogous macrolide immunosuppressants activate transient receptor potential melastatin 8 (TRPM8) ion channels.
Interaction site prediction between Falafel protein and several conserved tetrapeptide motifs.
2016 – 2017: Building simulation systems to study mu-opioid receptor activation mechanism
The large-scale molecular dynamics simulations of mu-opioid receptors in the native caveolar/raft-like membrane environment including raft-like membranes, PTMs, and intracellular proteins (G-protein or Arrestin).
2015 (6 months): Molecular characterization of 7a and 7b protein diad (melon necrotic spot virus) in the plant cell
Overexpression of 7A and 7B protein of MNSV in bacterial expression system to study the structure and antigenic properties of the protein.
Characterize these proteins using molecular biology techniques (SDS-PAGE, RT-PCR, cDNA synthesis, restriction digestion analysis).
2013 - 2015: The binding mechanism of 6-shogaol & menthol with serum proteins and its pharmacological importance
Cytotoxicity assay to check the potency of these drugs on Mouse macrophages and HeLa cell lines and calculate the cell response of these phytocompounds.
Spectroscopy, Circular Dichroism, Docking, and simulation study, to investigate the stability of the drug binding site of 6-shogaol and menthol in human serum albumin (HSA).
IOE-Postdoctoral fellowship, 2022-2024
Indian Institute of Science, Bangalore, India
ITC Scholarship, 2016-2017 (11 months)
HUN REN Biological Research Centre, Szeged, Hungary
INSPIRE Fellowship, 2016 (SELF DECLINED)
Department of Science and Technology (DST), India
UPEII Scholarship, 2015 (6 months)
University of Hyderabad, Hyderabad, India
INSPIRE Scholarship, 2013-2015
Department of Science and Technology (DST), India
INSPIRE Scholarship, 2010-2013
Department of Science and Technology (DST), India
Python, Shell, Latex, Linux, HPC computing, Molecular simulation (AT and CG), Streed MD, Enhanced sampling, Umbrella Sampling, GROMACS, MARTINI, CHARMM, Docking/AutoDock, Molecular modeling, Nanomaterials, Transmembrane proteins, lipid membrane, GPCRs