Part I. Investigation of Pathomechanisms and Drug Development of Neurodegenerative Diseases based on Brain-Gut Axis
(장뇌축 기반 퇴행성뇌질환의 병리기전 연구 및 치료후보물질 개발)
Kim YC*, Won SY*, Jeong BH. Altered expression of glymphatic system-related proteins in prion diseases: Implications for the role of the glymphatic system in prion diseases. Cell Mol Immunol. 2021, 18: 2281-2283 [2023 IF: 21.8; Immunol. JCR: 2.5%].*:Co-first author. [한빛사 논문 소개]
Sim HJ*, Kim YC*, Bhattarai G*, Won SY, Lee JC, Jeong BH, Kook SH. Prion infection modulates hematopoietic stem/progenitor cell fate through cell-autonomous and non-autonomous mechanisms. Leukemia. 2023, 37: 877-887. [2023 IF: 12.8; Hematol. JCR: 5.7%]. * :Co-first author [한빛사 논문 소개]
Zayed M*, Kim YC*, Jeong BH. Therapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion disease. Mol Neurodegener 2025, 20: 42. [2024 IF: 17.5; Immunol. JCR: 1.1%] * :Co-first author [한빛사 논문 소개]
Zayed M*, Kim YC*, Jeong BH. Biological characteristics and transcriptomic profile of adipose-derived mesenchymal stem cells isolated from prion-infected murine model. Stem Cell Res Ther 2025, In Press. * :Co-first author [2023 IF: 7.1; Vet. JCR: 8.1%]
Kim YC, Won SY, Jeong BH. Abnormal expression of proteolytic stress-related proteins and protective effect of fibrinolytic enzymes in prion diseases. Transbound Emerg Dis. 2025, 1: 9527934 [2020 IF: 5.005; Vet. JCR: 2.4%]
Zayed M*, Kim YC*, Jeong BH. Assessment of the therapeutic potential of Hsp70 activator against prion diseases using in vitro and in vivo models. Front Cell Dev Biol 2024, 12: 1411520 [2023 IF: 5.5, Develop Biol. JCR: 12.8%]. * :Co-first author
Part II. Early diagnosis for Neurodegenerative Diseases
(퇴행성뇌질환의 조기진단 연구)
Kim YC, Park KJ, Hwang JY, Park HC, Kang HE, Sohn HJ, Jeong BH. In-depth examination of PrP Sc in Holstein cattle carrying the E211K somatic mutation of the bovine prion protein gene (PRNP). Transbound Emerg Dis. 2022, 69: e356-e361 [2020 IF: 5.005; Vet. JCR: 2.4%] * :Co-first author. [한빛사 논문 소개]
Kim YC, Won SY, Jeong MJ, Jeong BH. Absence of proteinase K resistant PrP in Korean Holstein cattle carrying potential bovine spongiform encephalopathy-related E211K somatic mutation.Transbound Emerg Dis. 2022, 69: 805-812 [2020 IF: 5.005; Vet. JCR: 2.4%] * :Co-first author. [한빛사 논문 소개]
Part III. Identification of Novel Susceptible and Prognostic Biomarkers for Diseases based on Omics
(오믹스 기반 질병의 신규 민감성 및 예후 생체표지자 발굴)
Kim YC, Jeong MJ, Jeong BH. Strong association of regulatory single nucleotide polymorphisms (SNPs) of the IFITM3 gene with influenza H1N1 2009 pandemic virus infection. Cell Mol Immunol. 2020, 17:662-664 [2023 IF: 21.8; Immunol. JCR: 2.5%].
Kim YC, Lee J, Lee DW, Jeong BH. Large-scale lipidomic profiling identifying novel potential biomarkers for prion disease and highlighting lipid raft-related pathways. Vet Res. 2021, 52:105 [2022 IF: 4.4; Vet. JCR: 3.8%] [한빛사 논문 소개]
Kim YC, Jeong BH. Creutzfeldt-Jakob Disease Incidence, South Korea, 2001–2019. Emerg Infect Dis. 2022, 28: 1863-1866 [2022 IF: 16.126; Immunol. JCR: 7.76%] [한빛사 논문 소개]
Kim YC, Kim S, Kim HK, Lee Y, Shin C. Lee CS, Jeong BH. Genome-wide association study identifies eight novel loci for susceptibility of scrub typhus and highlights immune-related signaling pathways in its pathogenesis. Cells, 2021, 10: 570. [2021 IF: 7.666]
Park SH, Won SY, Kim YC. Identification of a disease-associated germline mutation (A64T) of the ring finger protein 186 gene (RNF186) in Korean patients with ulcerative colitis. Genes & Diseases 2024, 12: 101438. [2024 IF: 9.4; Genet & Hered. JCR: 3.4%]
Kim YC, Jeong BH. The first meta-analysis of the M129V single nucleotide polymorphism (SNP) of the prion protein gene (PRNP) with sporadic Creutzfeldt-Jakob disease. Cells 2021, 10: 3132. [2021 IF: 7.666]
Kim YC, Won SY, Jeong BH. Identification of prion disease-related somatic mutations in the prion protein gene (PRNP) in cancer patients. Cells 2020, 9:1480. [2021 IF: 7.666]
Kim YC, Jeong BH. Strong correlation between the case fatality rate of COVID-19 and the rs6598045 single nucleotide polymorphism (SNP) of the interferon-induced transmembrane protein 3 (IFITM3) gene at the population-level. Genes 2021, 12:42. [2022 IF: 4.3]
Kim YC, Jeong BH. Strong association of the rs4986790 single nucleotide polymorphism (SNP) of the toll-like receptor 4 (TLR4) gene with human immunodeficiency virus (HIV) infection: A meta-analysis. Genes 2021, 12:36. [2022 IF: 4.3]
Part IV. Research on the Genomes of Biological Species and Acquisition of Useful Biological Resources
(생물종 유전체 연구 및 유용 생물 자원 확보 )
Roh IS*, Kim YC*, Won SY, Jeong MJ, Park KJ, Park HC, Lee YR, Kang HE, Sohn HJ, Jeong BH. First report of a strong association between genetic polymorphisms of the prion protein gene (PRNP) and susceptibility to chronic wasting disease in sika deer (Cervus nippon). Transbound Emerg Dis. 2022, 69(5):e2073-e2083. [2020 IF: 5.005; Vet. JCR: 2.4%] * :Co-first author. [한빛사 논문 소개]
Lee YR*, Kim YC*, Won SY, Jeong MJ, Park KJ, Park HC, Roh IS, Kang HE, Sohn HJ, Jeong BH. Identification of a novel risk factor for chronic wasting disease (CWD) in elk: S100G single nucleotide polymorphism (SNP) of the prion protein gene (PRNP). Vet Res. 2023, 6;54: 48. * :Co-first author [2022 IF: 4.4; Vet. JCR: 3.8%].
Roh IS*, Kim YC*, Won SY, Park KJ, Park HC, Hwang JY, Kang HE, Sohn HJ, Jeong BH. Association Study of the M132L Single Nucleotide Polymorphism With Susceptibility to Chronic Wasting Disease in Korean Elk: A Meta-Analysis. Front Vet Sci 2022, 8:804325. [2022 IF: 3.2; Vet. JCR: 8%]. * :Co-first author
Han CS, Won SY, Park SH, Kim YC. Identification of the highly polymorphic prion protein gene (PRNP) in frogs (Rana dybowskii). Animals, 2025, 15: 220 [2023 IF: 2.7; Vet. JCR: 9.3%].
Part V. Prion diseases
(프리온 질환)