Anica Scholz
Anica Scholz
Institute of Biochemistry I
Department of Medicine
Goethe University Frankfurt
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Anica Scholz is a Ph.D. candidate at the Institute of Biochemistry I at the Department of Medicine at Goethe University Frankfurt. She holds an M.Sc. in Molecular Bio Sciences and a B.Sc. in Biological Sciences from Goethe University Frankfurt. She graduated with honors at the top of her class and was the first graduate ever to finish the program with a perfect grade point average (1.0). For her academic performance and extracurricular activities, she was awarded numerous merit-based scholarships, e.g. from the Studienstiftung des deutschen Volkes (top 0.5% of German student population), the Deutschlandstipendium from Goethe University Frankfurt and a Ph.D. scholarship from the Stiftung Polytechnische Gesellschaft.
Her research interests are translational regulation in the inflammatory tumor microenvironment, next-generation sequencing (NGS), ribosome profiling, upstream open reading frames and bioinformatics. She conducts empirical research using different NGS techniques especially ribosome and protein occupancy profiling. She has performed bioinformatics analyses for RNA-sequencing, low-input RNA-sequencing, ribosome profiling, protein occupancy profiling and whole exome sequencing (WES) experiments. Using her programming skills in R and Python, she established a novel bioinformatics pipeline for the identification of regulatory upstream open reading frames (uORFs). At the Institute of Biochemistry I, she is responsible for the NextSeq 500 sequencing machine and has supervised various collaboration partners and students performing NGS experiments.
Her research was published in numerous peer-reviewed journals such as Cellular and Molecular Life Sciences, PLoS One and Cell Reports. She contributed to various conferences such as the 24th Annual Meeting of the RNA Society (invited speaker) and the 10th International Symposium on the Biology of Acinetobacter (speaker, talk selected from abstract).
Scholz A, Rappl P, Böffinger N, Mota AC, Brüne B, Schmid T. (2019) Translation of TNFAIP2 is tightly controlled by an upstream open reading frame. In: Cell Mol Life Sci, doi: 10.1007/s00018-019-03265-4
Scholz A, Eggenhofer F, Gelhausen R, Grüning B, Zarnack K, Brüne B, Backofen R, Schmid T. (2019) uORF-Tools-Workflow for the determination of translation-regulatory upstream open reading frames. In: PLoS One, 14:e0222459
Hildebrandt A, Brüggemann M, Rückle C, Boerner S, Heidelberger JB, Busch A, Hänel H, Voigt A, Möckel MM, Ebersberger S, Scholz A et al. (2019) The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation. In: Genome Biol, 20:216
Ortmann CA, Dorsheimer L, Abou-El-Ardat K, Hoffrichter J, Assmus B, Bönig H, Scholz A, Pfeifer H, Martin H, Schmid T et al. (2019) Functional dominance of CHIP-mutated hematopoietic stem cells in patients undergoing autologous transplantations. In: Cell Reports, 27:2022–2028
Han Y, Mora J, Huard A, da Silva P, Wiechmann S, Putyrski M, Schuster C, Elwakeel E, Lang G, Scholz A et al. (2019) IL-38 ameliorates skin inflammation and limits IL-17 production from γδ T cells. In: Cell Reports, 27:835-846
Winslow S, Scholz A, Rappl P, Brauss TF, Mertens C, Jung M, Weigert A, Brüne B, Schmid T. (2019) Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation. In: PloS One 14, e0209694
Zeidler S, Hubloher J, König P, Ngu ND, Scholz A, Averhoff B, Müller V. (2018) Salt induction and activation of MtlD, the key enzyme in the synthesis of the compatible solute mannitol in Acinetobacter baumannii. In: MicrobiologyOpen 7, e00614
Lampe S, Kunze M, Scholz A, Brauss TF, Winslow S, Simm S, Keller M, Heidler J, Wittig I, Brüne B, Schmid T. (2018) Identification of the TXNIP IRES and characterization of the impact of regulatory IRES trans-acting factors. In: BBA-Gene Regul Mech, 2:147-157
Brauss TF, Winslow S, Lampe S, Scholz A, Weigert A, Dehne N, von Stedingk K, Schmid T, Brüne B. (2017) The RNA-binding protein HuR inhibits expression of CCL5 and limits recruitment of macrophages into tumors. In: Mol Carcinog, 56:2620-2629
Scholz A, Stahl J, de Berardinis V, Müller V, Averhoff B. (2016) Osmotic stress response in Acinetobacter baylyi: identification of a glycine-betaine biosynthesis pathway and regulation of osmoadaptive choline uptake and glycine-betaine synthesis through a choline-responsive BetI repressor. In: Environ Microbiol Rep, 8:316-22
Scholz A, Böffinger N, Aigner D, Brüne B, Schmid T. (2019) Translational regulation of IL32 in the inflammatory tumor microenvironment.
Scholz A (Invited Speaker), Böffinger N, Aigner D, Brüne B, Schmid T. (2019) Translational regulation of IL32 in the inflammatory tumor microenvironment. The 24th Annual Meeting of the RNA Society, Krakow, Poland
Scholz A (Speaker). (2018) uORF-Tools –Workflow for the determination of uORFs. RMU-RNA Salon “Genomics approaches in RNA biology”, Marburg, Germany
Lampe S, Brauss TF, Kunze M, Scholz A, Winslow S, Brüne B and Schmid T. (2017) hnRNPA1 is a regulator of UNR IRES activity. The AACR Special Conference on Translational Control of Cancer: A New Frontier in Cancer Biology and Therapy, San Francisco, USA
Scholz A (Speaker, talk selected from abstract) and Averhoff B. (2015) Osmotic stress tolerance of Acinetobacter baylyi: identification of a choline - glycine betaine pathway gene cluster and its transcriptional regulation. The 10th International Symposium on the Biology of Acinetobacter, Athens, Greece
Scholz A and Averhoff B. (2014) Osmotic stress tolerance of Acinetobacter baylyi: identification of a choline - glycine betaine pathway gene cluster and its transcriptional regulation. The 4th Joint Conference of VAAM and DGHM Microbiology and Infection, Dresden, Germany
Stahl J, Scholz A, Sand M, Averhoff B. (2014) The success of Acinetobacter baumannii in human host: Role of phospholipases in metabolic- and stress adaptation. Microbial Stress Response Gordon Research Conference, South Hadley, USA
Dytyuk Y, Scholz A, Büchel C, Dietzel L. (2013) Light-quality acclimation via photosynthetic redox signals in Cyclotella meneghiniana. The 12th International Colloquium on Endocytobiosis and Symbiosis, Halifax, Canada