Created by the insane Drukhari masters of pain and the dark arts of fleshcrafting known as the Haemonculi, the Talos was first constructed as a torture device, but is now employed across the galaxy's innumerable battlefields. Sweeping forward upon anti-gravitic motors, the Talos catches its victims with its razor-sharp claws and then incinerates them from the inside out.

The Talos is just one type of Pain Engine employed by the Drukhari Haemonculi, who are endlessly inventive in discovering new ways of dealing out pain and horror. Each of the Haemonculi Covens is always seeking to create their own, proprietary Engines of Pain that will give them a leg up over their rivals. Several of these variants of the standard Talos include:


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The Fox Engine was a proprietary game engine by Konami.[1] The engine's development began with Hideo Kojima after the completion of 2008's Metal Gear Solid 4, with the goal of making the "best engine in the world."[2] The first commercially released title to use the Fox Engine was Pro Evolution Soccer 2014.

The engine was designed to make it possible for Kojima Productions to develop multiplatform games with a significantly shortened development time[2] and has been described as the first step for the developer to move away from development for a single platform.[3] The engine is named after FOX, a fictional military unit from the Metal Gear series, wherein is also a reflection of Kojima Productions itself, which based its company logo on FOX's fox emblem.

A demo of the engine was shown at Konami's conference at E3 2011. Taking place in a jungle environment, the demo showed off the engine's visual capabilities and featured a young man running around the area, as well as a horse and a dog.[5] The tech-demo was not showcasing a game to be released; instead, it showed a test area for the development of the engine, based on assets created for Metal Gear Solid V: The Phantom Pain.[1] Kojima Productions planned to use the engine for all future titles, most prominently in Metal Gear Solid V: The Phantom Pain, which was revealed by Hideo Kojima, the series creator at a special 25th anniversary of the series event in Tokyo.[6]

On March 2, 2012, the Development Without Borders website uploaded a "classified" CD labeled "Fox Engine Lighting Sample" that contained two pictures of the Kojima Productions staff room, and asked which picture was real, and which was a simulation created using the Fox Engine. Clicking on the images would reveal which image was which, and explained more about how the engine simulated the staff room. The second slide also depicted some hoops and levitating balls of varying colors and materials on the table, as well as a picture of a horse in the staff room.

In February 2012, a site owned by Konami, "Development Without Borders", promoted development for a new Metal Gear title, for "The "next" MGS". The site was recruiting staff for the 2012 GDC pavilion in March, and requested applications for several positions for the latest Metal Gear Solid targeted for "high-end consoles" and a "next-gen Fox engine".[46][47] As the year went on, screenshots and videos of the newly announced Fox Engine were unveiled by the team.[48] This media demonstrated many random settings and characters, although none related to the Metal Gear series. Certain screenshots, however, were noted to feature a character who resembled the Big Boss character of Metal Gear, walking up to a Stryker AFV previously seen in Metal Gear Solid 4.[49]

Konami unveiled Ground Zeroes at a private function celebrating the twenty-fifth anniversary of the Metal Gear series on August 30, 2012. The game made its public debut two days later at the 2012 Penny Arcade Expo.[50] Kojima revealed very little detail about the project at the time other than that it was a prologue to Metal Gear Solid V,[51] and that it would be the first game to use the Fox Engine, a game engine developed by Kojima Productions.[52] In January 2013, Kojima revealed that Ground Zeroes would be the first title in the series to be subtitled in Arabic, a feature the team had planned for previous games.[53] He also confirmed that the length of the cutscenes was reduced, as he believed that long cutscenes had become outdated.[16][54]

In an interview with GameTrailers on March 29, 2013, Kojima revealed that The Phantom Pain was initially presented as an independent game so as to assess the public and industry response to the Fox Engine, as he felt that announcing the game as part of Metal Gear Solid V would bias reactions to the engine. He stated the idea had been conceived and planned with Keighley over the course of two years and was designed to encourage social media activity from fans.[69][70]

Metal Gear Solid V: The Phantom Pain was released in different editions. Special Day One editions of the game for each platform featured downloadable content (DLC) vouchers for special weapons and Metal Gear Online experience points. The North American Collector's Edition (which was available for PS4 and Xbox One) comes with a steelbook and a small-size replica of Snake's bionic arm; the Premium Package for the Japanese release (which was available for PS4, PS3, and Xbox One) features a full-size replica, which was also sold separately in May 2016.[98] Sony released a PlayStation 4 bundle with the unit painted in the colors of the arm.

Results:  Finally, 19 RCTs with a sample size of 456 subjects in the intervention group and 470 in the control group were included in the meta-analysis. The low back pain intensity in the intervention group decreased up to 1.261  0.213 (SMD  95% CI) with I2 = 87.60 more than that in the control group (P 80%) this result should be considered with caution. Meta-regression analysis showed the effect of pelvic floor muscle-strengthening exercises increased by increasing the year of publication, quality assessment score of the article, and the number of weeks of intervention (P

Conclusion:  Based on the results of the present meta-analysis, pelvic floor muscle-strengthening exercises significantly reduce the low back pain intensity. Therefore, these exercises can be regarded as a part of a low back pain management plan.

Cryotherapy, also known as cold therapy, has been physiological and clinically proven to reduce musculoskeletal pain, muscle spasms, connective tissue distension, hemorrhage, inflammation, and nerve conductivity [10]. This therapy has been frequently applied for pain management and postoperative care for sports injuries and surgical procedures and has been effective in reducing edema and recovery time, with short-term applications in abdominal, orthopedic, and gynecological operations [15,16,17,18,19]. Basically, low temperatures cause vasoconstriction, and pain reduction is achieved because the temperature blocks nerve endings [11]. This analgesic effect is the combination of slower propagation of neural pain signals and decreased release of chemical pain mediators, which also triggers a decrease in metabolism by more than 50%, allowing better oxygen flow to the injured tissues [20].

In dentistry, cryotherapy has already been adopted by professionals, especially for postoperative pain control after surgical procedures [21,22]. Although the effectiveness of cryotherapy has been well established in the literature, there is no standardization of the type or volume of the cryoagent used, mode of application, or duration to identify an ideal protocol for this treatment [16,23].

All studies assessed postoperative pain through a VAS [24,25,26,27,28,29,30,31]. The period evaluated ranged from 6 hours to 7 days. Only 3 studies specified the postoperative medications used (ibuprofen) [24,26,28].

Several of these articles concluded that intracanal cryotherapy is effective in reducing postoperative pain when compared with that in the control group, and lower pain levels were observed over the course of the analyzed time [24,25,26,27,28,29].

Due to the technical limitations of endodontic treatment instrumentation and the complexity of the root canal system anatomy, irrigating solutions play a very important role in the removal of organic and inorganic debris from areas where instruments cannot reach [38]. NaOCl is the most used irrigant in endodontics due to its broad antimicrobial activity and the ability to dissolve organic matter, even though it is irritating to periapical tissues, especially at high concentrations [39,40,41,42]. NaOCl concentration was a variable factor in several studies, ranging from 2.5 to 5.25%; only one study did not report the concentration used [29]. Negative pressure irrigation was used in several of the studies and is a safe method that aims to minimize the risks of irrigating agent leakage and thus, not interfere with postoperative pain assessment [24,28,30]. Knowing that foraminal enlargement was not performed in all studies and that irrigation was performed at working lengths using safe methods, despite the different irrigation protocols, we can state that postoperative pain scores and pain severity were not related to these factors. Another factor that reduces the risk of bias is that, regardless of the concentrations of the solution and the different irrigation protocols, the same methods were applied for all groups in each study.

Pain threshold and its assessment are subjective and vary considerably among individuals [43]. All studies included in this systematic review used the VAS as a method for postoperative pain assessment. This instrument is commonly used, because it is a simple and relevant method for pain intensity assessment [44]; nevertheless, it does not identify the source of the pain, which is a disadvantage. In addition, studies can use it with different measurements and time intervals, but not prevent the analysis and compilation of data since this instrument is effective in the analysis of endodontic postoperative pain [24,25,26,27,28,29,30,31]. be457b7860

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