Resume

Assistant Research Scientist @ NYU Langone Health

M. No. - +1-908-548-2536

Hi, I'm Aman Sharma,

Innovative researcher with expertise in CAR-T cell engineering, tumor antigen discovery, protein expression to advance therapeutic solutions in cancer immunotherapy and precision medicine. With expertise in CAR-T cell engineering, tumor antigen discovery, and molecular biology, I aim to develop innovative approaches to address unmet challenges in cancer treatment.

Currently, I work as an Assistant Research Scientist at the Perlmutter Cancer Center, NYU Langone Health, focusing on tumor target discovery, cross-HLA targeting, and pMHC production. My work combines computational biology, experimental research, and cutting-edge bioprocess optimization to create impactful solutions in immunotherapy.

Let’s explore the boundaries of science together.

PUBLICATIONS

A pan-cancer atlas of T cell targets- Guangyuan Li, Omar Uriel Guzman-Bringas, Aman Sharma, Zachary Harpaz, Ethan Tardio, Aswin Natarajan, Xinya Liu, Darren Taylor, Rachel Yamin, Maxence Dellacherie, Michelle Krogsgaard, C. Russell Y. Cruz, Mark Yarmarkovich, bioRxiv 2025.01.22.634237; doi: https://doi.org/10.1101/2025.01.22.634237
Aman, S. et al. Baby Foods Based on Cereals. In: Guti´errez, T.(eds) Food Science, Technology and Nutrition for Babies and Children. Springer, Cham. https://doi.org/10.1007/978-3-030-35997-3 4
A. Sharma et al. Study and Design of Portable Antimicrobial Water Filter : Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 9, Sept. 2017, pp. 268-71 https://doi.org/10.22159/ajpcr.2017.v10i9.19925

EDUCATION

Master of Technology (M.Tech)- Bio Process Engineering (2020-22)

Coursework-

Advanced Biochemistry
Bioprocess Control
Principle of Neuroscience
Downstream Processing,
Transport Phenomena in Biological Systems,
Bioreactor Design and Analysis,
Computer Simulations of Biomolecular Systems,
Thermodynamics in Biochemical Engineering.

Bachelor of Technology - Biotechnology (2016-20)

- - Core: - Molecular Biology, Biochemistry, Microbiology, Genetic Engineering, Genomics, Proteomics, Bio-Inspired Design, Bioinformatics, Immunology and Immnutechnology, Developmental Biology and Regenerative Medicine, Stem Cell Technology, Biological Spectroscopy, Food Biotechnology, Food Process Technology, Industrial Biotechnology, Analytical Techniques in Biotechnology, Chemical Reaction Engineering and Unit Operations, Nanobiotechnology.
  - Non-Core: - Problem Solving and Programming, Bio-business, Social Entrepreneurship, Lean Start-up Management, Problem Solving and Object Oriented Programming, Hospital Management, Code Mithra, Technical Answers for Real World Problems, Introduction to Innovative Projects
  - Soft Skills: - Ethics and Values, Introduction to Etiquette, Red Cross, Preparedness for External Opportunities, Preparedness for Career Opportunities

PROFESSIONAL EXPERIENCE

Assistant Research Scientist- Perlmutter Cancer Center, NYU Grossman School of Medicine (Sept 2023- Current)

Applied computational pipelines (OptiType) and HPC workflows for HLA typing, RNA-seq analysis, and TCGA data mining, identifying and validating high-affinity neoantigens from 1,000+ tumor samples to accelerate biomarker discovery.
Designed RNA-seq analysis workflows and mutation visualization tools (Manhattan plots) for 15+ cancer types, revealing therapy-resistant genomic hot-spots.
Develop and optimize Cross-HLA CAR-T cell therapies through protein engineering (pMHC production), CAR library screening, and flow cytometry-based validation to enhance tumor-specific targeting.

Graduate Teaching Fellow- Biology FIIITJEE Ltd (Dec 2022- July 2023)

Lectured 80+ medical aspirants (NEET/AIIMS), designing study materials that boosted exam scores.
Provided personalized mentorship, elevating students’ rankings through tailored strategies

Research Exchange Scholar- Institute Pascal UMR CNR, Universite Clermont Auvergne, Clermont-Ferrand, France, (Sept 2021 - Dec 2021)

Optimized DHA production in Crypthecodinium cohnii using lactate fermentation, applying FSEOF (Flux Scanning based on Enforced Objective Flux) to identify key metabolic reactions, achieving a 2-fold increase in theoretical yield through targeted flux enforcement and GC/HPLC analysis.

Quality Control Intern- Kausikh Therapeutics Pvt. Ltd., Chennai, Tamil Nadu, India, (May 2019 - June 2019)

Performed quality control and microbiological analysis of therapeutic products
Assisted in implementing GMP standards in manufacturing processes

PROJECT WORKS

Production of Essential Fatty acids from Supplement of Lactic Ferment Culture & Stoichiometric Modeling-Based Analysis of Docosahexaenoic Acid (DHA) Production- Guided by: Dr. Gwendoline Christophe, Polytech Clermont-Ferrand & Dr. Guhan Jayaraman, IIT Madras.

Conducted research on Crypthecodinium cohnii to enhance DHA and EPA production using lactic acid as an alternative carbon substrate, achieving significant improvements in yield.
Utilized HPLC and GC techniques for detailed analysis of lipid profiles, ensuring accurate quantification and optimization of essential fatty acid production.
Applied stoichiometric modeling and Flux Scanning based on Enforced Objective Flux (FSEOF) analysis to identify metabolic targets, resulting in a two-fold increase in DHA production efficiency.

Modelling and Control of Cold Storage Thermal Stability for Agricultural Products- Guided by: Prof. Dr. Nirav PravinBhai Bhatt, IIT Madras
1. - Created a model to correlate the thermal variation and regulation of thermal energy on food or agricultural products and focuses on a nonlinear dynamic thermal energy in Cold Storage tanks.

3. Degradation of Lambda-cyhalothrin by Bacterial Strains- Guided by: Dr. Jayanthi Abraham, VIT Vellore

Achieved Isolation of the potential bacterial strains for the transformation and biodegradation of Lambda-cyhalothrin pesticide & bio-remediation of Lambda-cyhalothrin with the effective microbes and enzymes to degrade and detoxify the pollutants from the environment

4. A Bio-Mechanical Gait Pattern Review of Cheetah (Acinoyx jubatus)

This project aims to provide the structural and gait pattern analysis of the cheetah. Demonstrates the structural, anatomical and physiological properties which allows cheetah to achieve such velocity.

5. Study of Biotin-Human Serum Albumin (HSA) interaction through spectroscopic analysis - Guided by Dr. Priyankar Sen, VIT Vellore.

Study of kinetics of the interaction between proteins and ligands, to get guidelines of various drug dosages to patients suffering from acute pathogenic diseases.

6. Study of Nano-Biotechnological Methods for Cannabinoid Delivery In Cancer Treatment - Guided by Dr. Amitava Mukherjee, VIT Vellore

Formulated and enhanced drug loading property of PGLA nanoparticles to act effectively to cancerous cells.

7. Study on Green-Synthesis and Characterization of Zinc Oxide Nanoparticles using Azadirachta indica- Guided by Prof. Dhritiman Gupta, VIT Vellore.

Succeeded in production of potential nanoparticles to develop clean technologies, to minimize environmental and human health risks associated with the manufactures and use of nanotechnology products.

CERTIFICATIONS

MATLAB On-ramp, Math Works Training Services, 2021
Computational Neuroscience, University of Washington, Coursera, 2020
Training for Trainers, NPTEL (2019)
Whole genome sequencing of bacterial genome-tools and applications, Technical University of Denmark (DTU), Coursera, 2019
R Programming- John Hopkins University, Coursera, 2018
DNA Bar-coding Workshop, 201

RESEARCH INTERESTS

CAR-T Cell Engineering: Developing universal CAR libraries and targeting neuroendocrine tumor antigens.
Antigen Discovery: Identifying tumor-specific and shared antigens for robust immunotherapies.
pMHC Production: Improving biophysical stability and scalability of pMHC complexes.
Cross-HLA Targeting: Exploring novel mechanisms for universal therapies applicable across diverse HLA types.
Cancer Genomics: Leveraging RNA-Seq and immunopeptidomics to inform clinical decisions.

SKILLS

Technical Expertise

Molecular Biology: Protein expression & Purification(FPLC, affinity chromatography), Gibson Assembly Cloning, DNA/RNA extraction and purification, PCR

• Cell Engineering: CAR T-Cell development, Library Preparation, Viral Vector production (Lentiviral/MLV), Cell Culture, Transfection/Transduction techniques

• Computational Biology: Python, R, MATLAB, Structural Modelling (PyMOL, VMD, AlphaFold), Immunopeptidome analysis, HPC workflows for neoantigen discovery, HLA typing, RNA-seq disambiguation, TCGA analysis

• Analytical: Flow Cytometry, Structural Protein analysis, Bioprocess modeling, Spectroscopy

CAR-T cell engineering
Neoantigen discovery
Structural modeling
Bioprocess optimization

About Me

With a Master’s degree in Bio-Process Engineering from IIT Madras and a Bachelor’s in Biotechnology from VIT Vellore, I have cultivated a strong foundation in molecular biology, computational biology, and bioprocess engineering. My work at the Perlmutter Cancer Center, NYU Langone Health, focuses on tumor target discovery, CAR-T cell engineering, and pMHC production, contributing to groundbreaking advances in cancer treatment.

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