Holy Spirit National High School is a public school that is situated in Barangay Holy Spirit in Quezon City, Philippines. The school is originally established as the annex school of Commonwealth High School in Barangay Holy Spirit, Quezon City, it was named Commonwealth High School Holy Spirit Annex. After gaining independence, the school’s name changed into Holy Spirit National High School in the year 2008. The school have approximately 3000 students and they are called as Holysians. A top-notch, easily accessible education for Barangay Holy Spirit pupils was a driving force behind the founding of Holy Spirit National High School. An annex would be built in the former barangay, according to a plan proposed by the local administration in response to the school's growing enrollment. Along with, 2012 when DepEd has been implementing the Senior High School (SHS) it refers to Grade 11 and 12, the last two years of the K to 12 programs.