Research & Projects

Optimization of Nanowell-Based Label-Free Impedance Biosensor Based on Different Nanowell Structures

This project was conducted at the NanoBioElectronics Lab, Rutgers University, under the supervision of Professor Mehdi Javanmard. I chose to pursue this work to improve sensitivity and reliability in nanostructured biosensors for cancer biomarker detection.

Objectives

Design potential nanowell structures.
Fabricate nanowell-based biosensors using cleanroom techniques.
Evaluate biosensor performance for biomarker detection.

Results

The optimized nanowell configurations demonstrated improved impedance sensitivity compared to conventional structures. The work provided important design guidelines for nanostructure-enabled biosensors and was published in Biosensors (2024).

Optimizing Nanowell Biosensor Fabrication: Statistical Evaluation of Metal Deposition and Oxide Layer Modification

Conducted at NanoBioElectronics Lab, Rutgers University, this study focused on understanding how fabrication parameters influence biosensor performance.

Objectives

Compare metal deposition methods (evaporation vs. sputtering).
Test oxide layer modifications in biosensor fabrication.
Statistically evaluate device performance across variations.

Results

The study showed that both metal deposition and oxide choice significantly influence sensitivity and reproducibility. These insights serve as a roadmap for robust biosensor fabrication protocols.

Nanowell-Based Impedance Biosensor for Label-Free Early Sepsis Diagnosis in Patient Serum

This project aimed to address the urgent clinical need for rapid sepsis diagnostics. Conducted at Rutgers University, it involved collaboration with clinical partners for patient sample collection.

Objectives

Collect human serum samples from sepsis patients.
Detect IL-6 biomarkers using nanowell biosensors.
Validate results against ELISA testing.

Results

The biosensor demonstrated strong agreement with ELISA assays, highlighting its potential as a rapid, label-free diagnostic tool for early sepsis detection.

Dynamic Sensing of Pressure Wounds in Spinal Cord Injury Models with Nanowell Biosensor

This study explored the role of biosensors in monitoring inflammatory biomarkers in wound healing, using animal models at Rutgers University.

Objectives

Measure IL-6 and TNF-α levels in wound fluid at multiple time points.
Validate sensor results against ELISA.

Results

The biosensor enabled real-time tracking of inflammation dynamics, offering insights into wound healing progression. This approach could help improve treatment monitoring in spinal cord injury patients.

Thyroid Nodule Impedance Measurement Scoring System (TN-IMS)

This project was part of a larger clinical effort at the University of Tehran to improve intraoperative thyroid cancer diagnostics.

Objectives

Collect thyroid nodule impedance data.
Perform statistical scoring and analysis.

Results

The scoring system demonstrated feasibility in distinguishing malignant from benign nodules. Results were published in Diagnostics (2022).

Real-Time Impedance Measurement System to Differentiate Healthy and Cancerous Head and Neck Lymph Nodes

This was my undergraduate thesis at the University of Tehran, supervised by Prof. Mohammad Abdolahad. It earned the Best B.Sc. Thesis Award in ECE.

Objectives

Design and fabricate needle and patch electrodes.
Operate the TDP impedance device during surgeries.
Collect and analyze lymph node samples.

Results

The system successfully distinguished healthy from cancerous lymph nodes intraoperatively, supporting clinical decision-making. Published in Surgery Today (2025).

Real-Time Monitoring of Peripheral Blood During and After Electrochemical Therapy (EChT) by Electrical Impedance Spectroscopy

Conducted at the University of Tehran, this project investigated impedance monitoring as a non-invasive method during EChT treatments for breast cancer patients.

Objectives

Develop two-needle impedance sensors.
Collect blood samples during/after therapy.
Compare results across patient groups.

Results

Findings confirmed measurable impedance changes linked to therapy response, offering a potential real-time monitoring tool. Published in International Journal of Cancer Management (2024).

Blood Impedance Spectroscopy (BIS) for Breast Cancer Diagnosis

This summer internship project at the University of Tehran focused on developing impedance-based diagnostic methods for breast cancer patients.

Objectives

Design and fabricate two-needle electrode sensors.
Conduct case studies on patients with different breast cancer grades.

Results

The system successfully differentiated blood impedance signatures across cancer stages, demonstrating the feasibility of non-invasive diagnostics.

Designing and Testing a Three-Electrode Platinum Biosensor for Cyclic Voltammetry Analysis of Seroma Fluid After Mastectomy

This project at the University of Tehran investigated biosensing approaches to anticipate local recurrence risk in breast cancer patients.

Objectives

Fabricate three-electrode platinum sensors.
Collect and analyze seroma fluid samples.

Results

The biosensor showed measurable electrochemical signatures associated with recurrence risk, highlighting potential for post-surgical monitoring.

Developing a Three-Electrode Sensor for Detecting ROS in Rat Sperm After Chemotherapy Injection

Conducted at the University of Tehran, this project focused on reproductive health monitoring in chemotherapy-exposed animal models.

Objectives

Fabricate and functionalize glassy carbon electrodes (GCE).
Measure ROS levels via cyclic voltammetry.

Results

The system successfully quantified ROS variations in sperm samples, providing a platform for evaluating chemotherapy-induced fertility effects.

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