Research

Research interests: high-dimensional data analysis, integrative analysis of genomic data, latent variable modeling, statistical genetics, survival analysis

Publications (Statistical Methodology)

1. Zhang, H., Qu, Y., Wong, K. Y., and Lee, C. Y. (2025+), "Bayesian analysis of Cox-type regression model with partly linear covariate effects via reversible jump Markov chain Monte Carlo," under review.

2. Zhou, Q. and Wong, K. Y. (2025+), "An optimal two-step estimation approach for two-phase studies," under review.

3. Kwok, N. S. and Wong, K. Y. (2025+), "Scalable likelihood-based estimation and variable selection for the Cox model with incomplete covariates," under review.

4. Feng, J. and Wong, K. Y. (2025), "Robust score tests for censored outcomes and incomplete covariates leveraging high-dimensional auxiliary variables," Statistica Sinica [online] DOI: 10.5705/ss.202024.0391.

5. Ng, H. M. and Wong, K. Y. (2025), "Penalized estimation for varying coefficient additive hazards models," Statistical Methods in Medical Research, 34, 1373–1384.

6. Ng, H. M. and Wong, K. Y. (2025), "A global kernel estimator for partially linear varying coefficient additive hazards models," Lifetime Data Analysis, 31, 205–232.

7. Feng, J., Wong, K. Y., and Lee, C. Y. (2024), "A semiparametric two-sample density ratio model with a change point," Biometrical Journal, 66, e202300214.

8. Zhou, Q. and Wong, K. Y. (2024), "Improving estimation efficiency of case-cohort studies with interval-censored failure time data," Statistical Methods in Medical Research, 33, 1673–1685.

9. Li, Y., Wong, K. Y., Howard, A. G., Gordon-Larsen, P., Highland, H. M., Graff, M., North, K. E., Downie, C. G., et al. (2024), "Multivariable Mendelian randomization with incomplete measurements on the exposure variables in the Hispanic Community Health Study/Study of Latinos," Human Genetics and Genomics Advances, 5, 100338.

10. Lee, C. Y., Wong, K. Y., and Bandyopadhyay, D. (2024), "Partly-linear single-index cure models with a nonparametric incidence link function," Statistical Methods in Medical Research, 33, 498–514.

11. Li, Y., Wong, K. Y., Howard, A. G., Gordon-Larsen, P., Highland, H. M., Graff, M., North, K. E., Downie, C. G., et al. (2023), "Mendelian randomization with incomplete measurements on the exposure in the Hispanic Community Health Study/Study of Latinos," Human Genetics and Genomics Advances, 5, 100245.

12. Lee, C. Y. and Wong, K. Y. (2023), "Survival analysis with a random change-point," Statistical Methods in Medical Research, 32, 2083–2095.

13. Ng, H. M., Jiang, B., and Wong, K. Y. (2023), "Penalized estimation of a class of single-index varying-coefficient models for integrative genomic analysis," Biometrical Journal, 65, 2100139.

14. Wong, K. Y. and Feng, J. (2023), "Score tests with incomplete covariates and high-dimensional auxiliary variables," Statistica Sinica, 33, 1483–1505.

15. Wong, K. Y., Zeng, D., and Lin, D. Y. (2023), "Penalized regression for multiple types of many features with missing data," Statistica Sinica, 33, 633–662.

16. Wong, K. Y., Zhou, Q., and Hu, T. (2023), "Semiparametric regression analysis of doubly-censored data with applications to incubation period estimation," Lifetime Data Analysis, 29, 87–114.

17. Lee, C. Y., Wong, K. Y., Lam, K. F., and Bandyopadhyay, D. (2023), "A semiparametric joint model for cluster size and subunit-specific interval-censored outcomes," Biometrics, 79, 2010–2022.

18. Wong, K. Y., Zeng, D., and Lin, D. Y. (2022), "Semiparametric latent-class models for multivariate longitudinal and survival data," The Annals of Statistics, 50, 487–510.

19. Lee, C. Y., Wong, K. Y., Lam, K. F., and Xu, J. (2022), "Analysis of clustered interval‐censored data using a class of semiparametric partly linear frailty transformation models," Biometrics, 78, 165–178.

20. Lam, K. F., Lee, C. Y., Wong, K. Y., and Bandyopadhyay, D. (2021), "Marginal analysis of current status data with informative cluster size using a class of semiparametric transformation cure models," Statistics in Medicine, 40, 2400–2412.

21. Wong, K. Y., Fan, C., Tanioka, M., Parker, J. S., Nobel, A. B., Zeng, D., Lin, D. Y. and Perou, C. M.  (2019), "I-Boost: an integrative boosting approach for predicting survival time with multiple genomics platforms," Genome Biology, 20, 52.

22.  Wong, K. Y., Zeng, D., and Lin, D. Y. (2019), "Robust score tests with missing data in genomics studies," Journal of the American Statistical Association, 114, 1778–1786.

23. Wong, K. Y., Zeng, D., and Lin, D. Y. (2018), "Efficient estimation for semiparametric structural equation models with censored data," Journal of the American Statistical Association, 113, 893–905.

24. Wong, K. Y., Goldberg, Y., and Fine, J. P. (2016), "Oracle estimation of parametric models under boundary constraints," Biometrics, 72,1173–1183.

25. Lam, K. F. and Wong, K. Y. (2014), "Semiparametric analysis of clustered interval-censored survival data with a cure fraction," Computational Statistics & Data Analysis, 79, 165–174.

26. Lam, K. F., Wong, K. Y., and Zhou, F. (2013), "A semiparametric cure model for interval-censored data," Biometrical Journal, 55, 771–788.

27. Wong, K. Y. and Lam, K. F. (2013), "Modeling zero-inflated count data using a covariate-dependent random effect model," Statistics in Medicine, 32, 1283–1293.

Publications (Inter-disciplinary Research)

1. De Lestrange-Anginieur, E., Pan, F., Thompson, B., and Wong, K. Y. (2025), "Eye-brain connection: An altered profile of spatial attention in myopia," Frontiers in Neuroscience, 19, 1593463.

2. Lau, L. C. M., Wong, K. Y., Hu, H., Cheung, M. H., Ng, F. Y., Fu, H., Chan, P. K., and Chiu, K. Y. (2025), "Cementless acetabular cup without screw holes with immediate full weight bearing: A minimum 20-year follow-up study," Bone and Joint Open, 6(Supple A), 14–21.

3. Yang, Y., Tse, Y.-S., Zhang, Q., Wong, K. Y., Yang, C., Yang, Y., Li, S., Lau, K. W., Charles, T. C., Lam, T. C., Zhao, Q. (2024) "Multiplexed target profiling with integrated chemical genomics and chemical proteomics," Journal of Medicinal Chemistry, 67, 17542–17550.

4. Young, C., Wong, K. Y., and Cheung, L. K. (2014), "Effectiveness of educational poster on knowledge of emergency management of dental trauma - Part 2: Cluster randomised controlled trial for secondary school students," PLoS One, 9(8), e101972.

5. Young, C., Wong, K. Y., and Cheung, L. K. (2014), "A survey on Hong Kong secondary school students’ knowledge of emergency management of dental trauma," PLoS One, 9(1), e84406.

6. Young, C., Wong, K. Y., and Cheung, L. K. (2013), "Effectiveness of educational poster on knowledge of emergency management of dental trauma - Part 1. Cluster randomised controlled trial for primary and secondary school teachers," PLoS One, 8(9), e74833.

7. Young, C., Wong, K. Y., and Cheung, L. K. (2012), "Emergency management of dental trauma: knowledge of Hong Kong primary and secondary school teachers," Hong Kong Medical Journal, 18, 362–370.

Grants

• Research Grants Council of Hong Kong General Research Fund (PI), 01/11/2024-31/10/2026. Project title: Survival analysis with longitudinal neuroimaging data. Funding level: 620,317HKD

• Research Grants Council of Hong Kong General Research Fund (PI), 01/01/2023-31/12/2025. Project title: Joint statistical analysis of survival times, longitudinal outcomes, and multi-platform omics data. Funding level: 615,000HKD

• Research Grants Council of Hong Kong Early Career Scheme (PI), 01/01/2019-31/12/2021. Project title: Statistical methods for integrative analysis of incomplete multi-platform genomic data. Funding level: 297,785HKD