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中心簡介
中心簡介
一站式照護 呵護健康
［我是一位原發性高醛固酮症患者，曾經歷了近20年的腎上腺困擾和恐慌症，不論我如何調整血壓，它總是居高不下；四肢無力的情況時有發生，每每湧起對未來的絕望］。或許您也有類似的經歷，就像自從感染了新冠肺炎後，不明原因的高血壓和疲倦，讓精神科醫師誤以為是憂鬱症所致。這些都可能是原發性高醛固酮症患者常見的病徵。為了回應這些挑戰，臺大醫院於2023年走在世界前列，成立了原發性高醛固酮症中心（PAC）。這個中心匯聚了內科、影像醫學科、核子醫學科、心理學科和泌尿科的專業知識，為病患提供一站式的正確診斷和治療方案，以實現高效率的高血壓管理策略。
症狀的煩惱：血壓失控 腦海恐慌
原發性高醛固酮症可能會導致嚴重的急性癱瘓症狀。這種罕見且症狀複雜的疾病，主要源於腎上腺皮質增生或腫瘤產生過多的醛固酮。患者可能會出現高血壓、低血鉀、肌無力、多尿、血漿腎素活性減少和高醛固酮血症等症狀，並且還可能增加中風或心臟衰竭的風險。
專業團隊攜手 全方位治療路徑
我們的團隊從2006年起投入原發性高醛固酮症的研究，經過近20年的努力，不僅成功制定了臺灣原發性高醛固酮症的診斷和治療標準，還深入探究了睡眠呼吸中止症候群、亞急性庫欣氏症等相關疾病。此外，我們團隊還進行了針對新發生心房顫動和患有高血壓的高醛固酮症患者的篩選研究，以確定是否罹患原發性高醛固酮症。
腎上腺疾病複雜性：從高血壓到心理影響
此外，由於腎上腺荷爾蒙異常，很多患者也可能出現恐慌、心悸和失眠等心理症狀，甚至可能發生急性癱瘓的情況。我們也引入了基因診斷和智慧醫療，以預測腎上腺切除的成功率。我們已經建立了臺灣腎上腺靜脈取樣的標準方案，推動低血鉀基因和腎上腺病理診斷。我們也在全球率先建立了醛固酮和可體松的荷爾蒙對話。我們的手術成功率在全球名列前茅，已經有大約3000位患者接受了治療，並且近年來我們已經發表了超過150篇相關論文。
Introduction
Introduction
One-Stop Care, Safeguarding Health
One-Stop Care, Safeguarding Health
“I am a patient with primary aldosteronism. For nearly 20 years, I suffered from adrenal-related disorders and panic attacks. No matter how I adjusted my blood pressure medications, it always remained uncontrollably high. Episodes of muscle weakness occurred frequently, often leaving me in despair about the future.” Perhaps you have had a similar experience. For example, after a COVID-19 infection, some may develop unexplained high blood pressure and fatigue, which psychiatrists may mistakenly attribute to depression. These are, in fact, common symptoms of primary aldosteronism. In response to these challenges, National Taiwan University Hospital established the Primary Aldosteronism Center (PAC) in 2023, becoming a world leader in the field. The center brings together expertise from internal medicine, medical imaging, nuclear medicine, psychiatry, and urology to provide patients with one-stop accurate diagnosis and treatment, aiming for highly efficient hypertension management strategies.
“I am a patient with primary aldosteronism. For nearly 20 years, I suffered from adrenal-related disorders and panic attacks. No matter how I adjusted my blood pressure medications, it always remained uncontrollably high. Episodes of muscle weakness occurred frequently, often leaving me in despair about the future.” Perhaps you have had a similar experience. For example, after a COVID-19 infection, some may develop unexplained high blood pressure and fatigue, which psychiatrists may mistakenly attribute to depression. These are, in fact, common symptoms of primary aldosteronism. In response to these challenges, National Taiwan University Hospital established the Primary Aldosteronism Center (PAC) in 2023, becoming a world leader in the field. The center brings together expertise from internal medicine, medical imaging, nuclear medicine, psychiatry, and urology to provide patients with one-stop accurate diagnosis and treatment, aiming for highly efficient hypertension management strategies.
Symptom Burden: Uncontrolled Blood Pressure and Mental Distress
Symptom Burden: Uncontrolled Blood Pressure and Mental Distress
Primary aldosteronism may lead to severe episodes of acute paralysis. This rare and complex condition is primarily caused by adrenal hyperplasia or tumors that produce excessive aldosterone. Patients may present with hypertension, hypokalemia, muscle weakness, frequent urination, reduced plasma renin activity, and hyperaldosteronism. In addition, they face an elevated risk of stroke and heart failure.
Primary aldosteronism may lead to severe episodes of acute paralysis. This rare and complex condition is primarily caused by adrenal hyperplasia or tumors that produce excessive aldosterone. Patients may present with hypertension, hypokalemia, muscle weakness, frequent urination, reduced plasma renin activity, and hyperaldosteronism. In addition, they face an elevated risk of stroke and heart failure.
A Professional Team: Comprehensive Pathways to Treatment
A Professional Team: Comprehensive Pathways to Treatment
Since 2006, our team has been devoted to research on primary aldosteronism. Over nearly 20 years, we have:
Established Taiwan’s standards for diagnosis and treatment
Explored its association with sleep apnea, subclinical Cushing’s syndrome, and other related diseases
Conducted screening studies in patients with newly diagnosed atrial fibrillation and hypertension to detect primary aldosteronism
The Complexity of Adrenal Disorders: From Hypertension to Psychological Impact
The Complexity of Adrenal Disorders: From Hypertension to Psychological Impact
Due to hormonal imbalance, many patients also experience panic, palpitations, and insomnia, and in some cases, even acute paralysis. To improve outcomes, we have introduced genetic diagnostics and precision medicine approaches to predict the success rate of adrenalectomy. We have also established Taiwan’s standard protocol for adrenal venous sampling, advanced genetic studies on hypokalemia, and refined adrenal pathology diagnosis. Our team pioneered the world’s first “hormonal dialogue” between aldosterone and cortisol. With a surgical success rate ranked among the highest globally, we have treated approximately 3,000 patients and published more than 150 scientific papers in recent years.
Due to hormonal imbalance, many patients also experience panic, palpitations, and insomnia, and in some cases, even acute paralysis. To improve outcomes, we have introduced genetic diagnostics and precision medicine approaches to predict the success rate of adrenalectomy. We have also established Taiwan’s standard protocol for adrenal venous sampling, advanced genetic studies on hypokalemia, and refined adrenal pathology diagnosis. Our team pioneered the world’s first “hormonal dialogue” between aldosterone and cortisol. With a surgical success rate ranked among the highest globally, we have treated approximately 3,000 patients and published more than 150 scientific papers in recent years.
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